Title:
MEANS AND METHODS FOR MONITORING PROTEASE INHIBITOR ANTIRETROVIRAL THERAPY AND GUIDING THERAPEUTIC DECISIONS IN THE TREATMENT OF HIV/AIDS
Document Type and Number:
WIPO Patent Application WO2002099387
Kind Code:
A3
Abstract:
This invention relates to antiviral drug susceptibility and resistance tests to be used in identifying effective drug regimens for the treatment of human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS), particularly treatment regimens including a protease inhibitor. The invention further relates to the means and methods of monitoring the clinical progression of HIV infection and its response to antiretroviral therapy using phenotypic or genotypic susceptibility assays.
Inventors:
PARKIN NEIL T
ZEIRMANN RAINER A
ZEIRMANN RAINER A
Application Number:
PCT/US2002/018684
Publication Date:
April 24, 2003
Filing Date:
June 04, 2002
Export Citation:
Assignee:
VIROLOGIC INC (US)
International Classes:
C07K14/16; C12Q1/37; C12Q1/70; G01N33/569; (IPC1-7): C12Q1/18; C12Q1/68; C12Q1/70
Other References:
ZIERMANN ET AL.: "A mutation in human immunodeficiency virus type 1 protease, N88S, that causes in vitro hypersensitivity to amprenavir", J. VIROLOGY, vol. 74, no. 9, May 2000 (2000-05-01), pages 4414 - 4419, XP002908352
See also references of EP 1407042A4
See also references of EP 1407042A4
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