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Title:
MEASURING HUMAN HEART MUSCLE VIABILITY USING MYOCARDIAL ELECTRICAL IMPEDANCE
Document Type and Number:
WIPO Patent Application WO2004105862
Kind Code:
A3
Abstract:
A method for detecting a quantitative measure of a physiologic state of a myocardium or coronary artery by detecting the extent of change of myocardial electrical impedance from a mean baseline value to provide diagnosis of the extent of ischemia, stenosis, tissue rejection, reperfusion and the effectiveness of cardioplegia . Electrodes (16,18) are attached to the myocardium (14), baseline measurements of the mean myocardial impedance are stored, and the variance of the myocardial electrical impedance and a baseline value of mean myocardial electrical impedance are computed from the baseline measurements using custom circuitry (12) and a computer (10). After a mean myocardial electrical impedance changes from a computed baseline value by at least the measured variance, the extent of change in the myocardial physiologic state is diagnosed as a continuous, smooth, function of the extent or rate of change of a periodically measured myocardial electrical impedance from the baseline value.

Inventors:
DZWONCZYK ROGER R (US)
DEL RIO CARLOS L (ES)
MCCONNELL PATRICK I (US)
HOWIE MICHAEL B (US)
Application Number:
PCT/US2004/017224
Publication Date:
March 03, 2005
Filing Date:
May 28, 2004
Export Citation:
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Assignee:
UNIV OHIO STATE (US)
DZWONCZYK ROGER R (US)
DEL RIO CARLOS L (ES)
MCCONNELL PATRICK I (US)
HOWIE MICHAEL B (US)
International Classes:
A61B5/05; A61B5/053; A61N; (IPC1-7): A61B5/05
Foreign References:
US5454377A1995-10-03
US5282840A1994-02-01
US5999854A1999-12-07
US6016445A2000-01-18
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