Many medicaments have to be injected into the body. This applies in particular to medicaments, which are deactivated or have their efficiency remarkably decreased by oral administration, e.g. proteines (such as insulin, growth hormones, interferons), carbohydrates (e.g. heparin), antibodies and the majority of vaccines. Such

medicaments are predominantly injected by means of syringes, medicament pens or medicament pumps. Some medicaments have to be administered by inhaling them from so called inhalers.

WO 2009/069518 A1 discloses an inhaler, wherein the medicament to be inhaled is stored in a bag shaped medicament container. US 5 330 431 discloses an infusion pump with a medicament container comprising a flexible bag with an outlet, the bag compressible by a compression means.

US 2001/016710 discloses a medication delivery device with a medicament container comprising a flexible bag with an outlet, the bag compressible by a compression means.

US 2 805 662 discloses a medicament container comprising a bag with an outlet, the bag compressible by a compression means. The bag has an inflexible lower half and a flexible upper half. The flexible upper half is intended to be subjected to the

compression means. EP 2 042 207 discloses a portable drug solution container for throat drug solutions, the container comprising a flexible bag with an outlet, the bag compressible by a compression means. US 2005/277887 discloses an infusion pump with a medicament container comprising a flexible bag with an outlet, the bag compressible by a compression means.

US 5 368 199 discloses a container for holding a hot melt material. The container comprises a susceptor layer, a microwave transparent layer and a heat transmissive and microwace transparent layer. The contained hot melt material is softened by heat generated by microwave radiation.

It is an object of the present invention to provide an improved medicament container.

It is a further object of the present invention to provide an injection arrangement which avoids delayed dripping and improves dose accuracy.

The object is achieved by a medicament container according to claim 1.

Preferred embodiments of the invention are given in the dependent claims.

An injection arrangement with a medicament container according to the invention comprises a bag with an outlet. The bag, preferably having a relatively thin skin, is compressible by a compression means so as to gradually reducing a volume of the bag and consequently squeezing the medicament stored in the bag out of the outlet similar to a tube of tooth paste. Since the outlet usually exhibits some kind of bottleneck, in particular when equipped with valves and/or injection needles, compression of the bag results in an internal pressure inside the bag. The bag is arranged to be flexible or soft in an area respectively subjected to the compression means and arranged to be essentially inflexible in the remaining areas or in the areas that have not yet been subjected to the compression means. This behaviour avoids a temporary expansion of the bag in the areas not subjected to the compression means due to the increased internal pressure so the effort expended in compressing the bag goes virtually entirely in the delivery of the medicament through the outlet rather than in expansion of the bag. The inventive arrangement avoids delayed dripping due to relaxation of the expanded bag when the advancement of the compression means is stopped. Furthermore, dosing may be performed with an improved precision.

The bag may comprise a thermally sensitive skin or skin layer, which is arranged for turning flexible upon subjection to a heated compression means and for being essentially inflexible when not heated or when cooled down after heating. This applies in particular to an outer skin layer which is in direct contact with the compression means rather than with the liquid content.

In another embodiment of the invention the bag comprises a skin or skin layer, that may be locally softened or turned flexible by subjection to at least one of a chemical agent, a radiation, a magnetic field, an electrical field, an electrical current and a mechanical influence. This applies in particular to an outer skin layer which is in direct contact with the compression means rather than with the liquid content.

In yet another embodiment the bag may comprise a skin with at least one flexible layer and a stiff outer skin layer, which is removable when subjected to the compression means.

The skin layer may comprise one of sugar, salt and wax which are essentially inflexible materials. The skin or skin layer may also comprise silver, e.g. in the shape of silver ions, wherein the skin or skin layer is arranged for being turned flexible or wherein the skin layer is arranged for being removed or dissolved by subjection to radiation with visible light or ultraviolet light. It is known from black and white photographic processing that properties of silver-bearing substances may be altered by subjecting them to radiation. The skin or skin layer may also comprise a UV sensitive polymer, wherein the skin or skin layer is arranged for being turned flexible or wherein the skin layer is arranged for being removed or dissolved by subjection to radiation with ultraviolet light as known from wafer exposure.

In a preferred embodiment of the invention the bag is arranged on an essentially planar, rigid support and a roller is arranged for locally pressing the bag against the support and advancing in a longitudinal direction of the bag. The roller may

alternatively be replaced by a shoe or wiper pressed against the bag and advancing without being rotated. The medicament container may be part of an injection arrangement or an inhaler arrangement for delivering a liquid medicament to a human or an animal.

The injection arrangement may comprise a valve and a hollow needle for piercing a patient's skin, the valve and needle being arranged at the outlet of the medicament container. In case of a jet injector, instead of the needle, a jet nozzle may be arranged.

The medicament container may preferably be used for delivering one of an analgetic, an anticoagulant, insulin, an insulin dehvate, heparin, Lovenox, a vaccine, a growth hormone, a peptide hormone, a proteine, and complex carbohydrates.

The skin or outer skin layer may also improve protection of the bag's contents against ambient influences.

Further scope of applicability of the present invention will become apparent from the detailed description given hereinafter. However, it should be understood that the detailed description and specific examples, while indicating preferred embodiments of the invention, are given by way of illustration only, since various changes and modifications within the spirit and scope of the invention will become apparent to those skilled in the art from this detailed description. The present invention will become more fully understood from the detailed description given hereinbelow and the accompanying drawings which are given by way of illustration only, and thus, are not limitive of the present invention, and wherein: Figure 1 is a schematic view of an injection arrangement comprising a

medicament container, a compression means and a support.

Figure 1 shows a schematic view of an injection arrangement 1 comprising a medicament container 2, a compression means 3 and a support 4.

The medicament container 2 comprises a bag 2.1 with an outlet 2.2. The bag 2.1 has a relatively thin skin and is compressible by the compression means 3. Thereby a volume of the bag 2.1 is gradually reduced and consequently a medicament stored in the bag 2.1 squeezed out of the outlet 2.2. The injection arrangement 1 further comprises a valve 5 and a hollow needle 6 arranged at the outlet 2.2. The

compression means 3 is in the shape of a roller which may be pressed with a force F against the support 4 which exerts a counteracting force F'. Due to this action the bag 2.1 is locally compressed between the compression means 3 and the support. The compression means may then be advanced with a speed v in the direction indicated by the arrow assigned to v, thereby gradually reducing the bag's 2.1 volume.

When the bag 2.1 is compressed an internal pressure inside the bag 2.1 increases. The bag 2.1 is arranged to be flexible or soft in an area respectively subjected to the compression means 3 and arranged to be essentially inflexible in the remaining areas or in the areas that have not yet been subjected to the compression means 3.

The bag 2.1 may comprise a thermally sensitive skin or skin layer, which is arranged for turning flexible upon subjection to a heated compression means 3 and for being essentially inflexible when not heated or cooled down after heating. This applies in particular to on outer skin layer which is in direct contact with the compression means 3 rather than with the liquid content. In another embodiment of the invention the bag 2.1 comprises a skin or skin layer, that may be locally softened or turned flexible by subjection to at least one of a chemical agent, a radiation, a magnetic field, an electrical field, an electrical current and a mechanical influence. The subjection to the respective medium may be exerted by the compression means 3 or by a separate arrangement advancing with the compression means 3.

In yet another embodiment the bag 2.1 may comprise a skin with at least one flexible layer and a stiff outer skin layer, which is removable when or before subjected to the compression means 3. E.g. the skin layer may be peeled of or unwound from the skin by means of the compression means 3 or another arrangement travelling ahead of the compression means 3. The skin layer may comprise one of sugar, salt and wax.

The skin or skin layer may also comprise silver, e.g. in the shape of silver ions, wherein the skin or skin layer is arranged for being turned flexible or wherein the skin layer is arranged for being removed or dissolved by subjection to radiation with visible light or ultraviolet light.

The compression means 3 in the shape of the roller may alternatively be replaced by a shoe or wiper pressed against the bag 2.1 and advancing without being rotated. The medicament container may be part of any kind of an injection arrangement or an inhaler arrangement for delivering a liquid medicament to a human or an animal.

Instead of the hollow needle 6 shown in the figure a jet nozzle may be provided. The medicament container 2 may preferably be used for delivering one of an analgetic, an anticoagulant, insulin, an insulin dehvate, heparin, Lovenox, a vaccine, a growth hormone, a peptide hormone, a proteine, and complex carbohydrates. The term "medicament", as used herein, means a pharmaceutical formulation containing at least one pharmaceutically active compound, wherein in one embodiment the pharmaceutically active compound has a molecular weight up to 1500 Da and/or is a peptide, a proteine, a polysaccharide, a vaccine, a DNA, a RNA, a antibody, an enzyme, an antibody, a hormone or an oligonucleotide, or a mixture of the above-mentioned pharmaceutically active compound, wherein in a further embodiment the pharmaceutically active compound is useful for the treatment and/or prophylaxis of diabetes mellitus or complications associated with diabetes mellitus such as diabetic retinopathy, thromboembolism disorders such as deep vein or pulmonary thromboembolism, acute coronary syndrome (ACS), angina, myocardial infarction, cancer, macular degeneration, inflammation, hay fever, atherosclerosis and/or rheumatoid arthritis, wherein in a further embodiment the pharmaceutically active compound comprises at least one peptide for the treatment and/or prophylaxis of diabetes mellitus or complications associated with diabetes mellitus such as diabetic retinopathy, wherein in a further embodiment the pharmaceutically active compound comprises at least one human insulin or a human insulin analogue or derivative, glucagon-like peptide (GLP-1 ) or an analogue or derivative thereof, or exedin-3 or exedin-4 or an analogue or derivative of exedin-3 or exedin-4.

Insulin analogues are for example Gly(A21 ), Arg(B31 ), Arg(B32) human insulin;

Lys(B3), Glu(B29) human insulin; Lys(B28), Pro(B29) human insulin; Asp(B28) human insulin; human insulin, wherein proline in position B28 is replaced by Asp, Lys, Leu, VaI or Ala and wherein in position B29 Lys may be replaced by Pro; Ala(B26) human insulin; Des(B28-B30) human insulin; Des(B27) human insulin and Des(B30) human insulin. Insulin derivates are for example B29-N-myristoyl-des(B30) human insulin; B29-N- palmitoyl-des(B30) human insulin; B29-N-myhstoyl human insulin; B29-N-palmitoyl human insulin; B28-N-myristoyl LysB28ProB29 human insulin; B28-N-palmitoyl- LysB28ProB29 human insulin; B30-N-myristoyl-ThrB29LysB30 human insulin; B30-N- palmitoyl- ThrB29LysB30 human insulin; B29-N-(N-palmitoyl-Y-glutamyl)-des(B30) human insulin; B29-N-(N-lithocholyl-Y-glutamyl)-des(B30) human insulin; B29-N-(ω- carboxyheptadecanoyl)-des(B30) human insulin and B29-N-(ω-carboxyheptadecanoyl) human insulin. Exendin-4 for example means Exendin-4(1-39), a peptide of the sequence H-His-Gly- Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu- Ala-Val-Arg-Leu-Phe- Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro- Pro-Ser-NH2.

Exendin-4 derivatives are for example selected from the following list of compounds:

H-(Lys)4-des Pro36, des Pro37 Exendin-4(1 -39)-NH2,

H-(Lys)5-des Pro36, des Pro37 Exendin-4(1 -39)-NH2,

des Pro36 [Asp28] Exendin-4(1-39),

des Pro36 [lsoAsp28] Exendin-4(1 -39),

des Pro36 [Met(O)14, Asp28] Exendin-4(1-39),

des Pro36 [Met(O)14, lsoAsp28] Exendin-4(1 -39),

des Pro36 [Trp(O2)25, Asp28] Exendin-4(1 -39),

des Pro36 [Trp(O2)25, lsoAsp28] Exendin-4(1-39),

des Pro36 [Met(O)14 Trp(O2)25, Asp28] Exendin-4(1-39),

des Pro36 [Met(O)14 Trp(O2)25, lsoAsp28] Exendin-4(1 -39); or des Pro36 [Asp28] Exendin-4(1-39),

des Pro36 [lsoAsp28] Exendin-4(1 -39),

des Pro36 [Met(O)14, Asp28] Exendin-4(1-39),

des Pro36 [Met(O)14, lsoAsp28] Exendin-4(1 -39),

des Pro36 [Trp(O2)25, Asp28] Exendin-4(1 -39),

des Pro36 [Trp(O2)25, lsoAsp28] Exendin-4(1-39), des Pro36 [Met(O)14 Trp(O2)25, Asp28] Exendin-4(1-39),

des Pro36 [Met(O)14 Trp(O2)25, lsoAsp28] Exendin-4(1 -39),

wherein the group -Lys6-NH2 may be bound to the C-terminus of the Exendin-4 derivative; or an Exendin-4 derivative of the sequence

H-(Lys)6-des Pro36 [Asp28] Exendin-4(1 -39)-l_ys6-NH2,

des Asp28 Pro36, Pro37, Pro38Exendin-4(1 -39)-NH2,

H-(Lys)6-des Pro36, Pro38 [Asp28] Exendin-4(1 -39)-NH2,

H-Asn-(Glu)5des Pro36, Pro37, Pro38 [Asp28] Exendin-4(1 -39)-NH2,

des Pro36, Pro37, Pro38 [Asp28] Exendin-4(1-39)-(l_ys)6-NH2,

H-(Lys)6-des Pro36, Pro37, Pro38 [Asp28] Exendin-4(1 -39)-(l_ys)6-NH2,

H-Asn-(Glu)5-des Pro36, Pro37, Pro38 [Asp28] Exendin-4(1 -39)-(l_ys)6-NH2, H-(Lys)6-des Pro36 [Trp(O2)25, Asp28] Exendin-4(1-39)-l_ys6-NH2,

H-des Asp28 Pro36, Pro37, Pro38 [Trp(O2)25] Exendin-4(1 -39)-NH2,

H-(Lys)6-des Pro36, Pro37, Pro38 [Trp(O2)25, Asp28] Exendin-4(1 -39)-NH2, H-Asn-(Glu)5-des Pro36, Pro37, Pro38 [Trp(O2)25, Asp28] Exendin-4(1 -39)-NH2, des Pro36, Pro37, Pro38 [Trp(O2)25, Asp28] Exendin-4(1-39)-(Lys)6-NH2,

H-(Lys)6-des Pro36, Pro37, Pro38 [Trp(O2)25, Asp28] Exendin-4(1 -39)-(Lys)6-NH2, H-Asn-(Glu)5-des Pro36, Pro37, Pro38 [Trp(O2)25, Asp28] Exendin-4(1 -39)-(Lys)6- NH2,

H-(Lys)6-des Pro36 [Met(O)14, Asp28] Exendin-4(1-39)-Lys6-NH2,

des Met(O)14 Asp28 Pro36, Pro37, Pro38 Exendin-4(1 -39)-NH2,

H-(Lys)6-desPro36, Pro37, Pro38 [Met(O)14, Asp28] Exendin-4(1 -39)-NH2,

H-Asn-(Glu)5-des Pro36, Pro37, Pro38 [Met(O)14, Asp28] Exendin-4(1 -39)-NH2, des Pro36, Pro37, Pro38 [Met(O)14, Asp28] Exendin-4(1 -39)-(Lys)6-NH2,

H-(Lys)6-des Pro36, Pro37, Pro38 [Met(O)14, Asp28] Exendin-4(1 -39)-(Lys)6-NH2, H-Asn-(Glu)5 des Pro36, Pro37, Pro38 [Met(O)14, Asp28] Exendin-4(1 -39)-(Lys)6- NH2,

H-Lys6-des Pro36 [Met(O)14, Trp(O2)25, Asp28] Exendin-4(1 -39)-Lys6-NH2, H-des Asp28 Pro36, Pro37, Pro38 [Met(O)14, Trp(O2)25] Exendin-4(1-39)-NH2, H-(Lys)6-des Pro36, Pro37, Pro38 [Met(O)14, Asp28] Exendin-4(1 -39)-NH2, H-Asn-(Glu)5-des Pro36, Pro37, Pro38 [Met(O)14, Trp(O2)25, Asp28] Exendin-4(1 - 39)-NH2,

des Pro36, Pro37, Pro38 [Met(O)14, Trp(O2)25, Asp28] Exendin-4(1-39)-(l_ys)6-NH2, H-(Lys)6-des Pro36, Pro37, Pro38 [Met(O)14, Trp(O2)25, Asp28] Exendin-4(S1-39)- (Lys)6-NH2,

H-Asn-(Glu)5-des Pro36, Pro37, Pro38 [Met(O)14, Trp(O2)25, Asp28] Exendin-4(1 - 39)-(Lys)6-NH2; or a pharmaceutically acceptable salt or solvate of any one of the afore-mentioned Exedin-4 derivative.

Hormones are for example hypophysis hormones or hypothalamus hormones or regulatory active peptides and their antagonists as listed in Rote Liste, ed. 2008, Chapter 50, such as Gonadotropine (Follitropin, Lutropin, Chohongonadotropin,

Menotropin), Somatropine (Somatropin), Desmopressin, Terlipressin, Gonadorelin, Triptorelin, Leuprorelin, Buserelin, Nafarelin, Goserelin.

A polysaccharide is for example a glucosaminoglycane, a hyaluronic acid, a heparin, a low molecular weight heparin or an ultra low molecular weight heparin or a derivative thereof, or a sulphated, e.g. a poly-sulphated form of the above-mentioned

polysaccharides, and/or a pharmaceutically acceptable salt thereof. An example of a pharmaceutically acceptable salt of a poly-sulphated low molecular weight heparin is enoxapahn sodium. Pharmaceutically acceptable salts are for example acid addition salts and basic salts. Acid addition salts are e.g. HCI or HBr salts. Basic salts are e.g. salts having a cation selected from alkali or alkaline, e.g. Na+, or K+, or Ca2+, or an ammonium ion

N+(R1 )(R2)(R3)(R4), wherein R1 to R4 independently of each other mean: hydrogen, an optionally substituted C1 -C6-alkyl group, an optionally substituted C2-C6-alkenyl group, an optionally substituted C6-C10-aryl group, or an optionally substituted C6- C10-heteroaryl group. Further examples of pharmaceutically acceptable salts are described in "Remington's Pharmaceutical Sciences" 17. ed. Alfonso R. Gennaro (Ed.), Mark Publishing Company, Easton, Pa., U.S.A., 1985 and in Encyclopedia of Pharmaceutical Technology.

Pharmaceutically acceptable solvates are for example hydrates.

List of References

1 injection arrangement

2 medicament container

2.1 bag

2.2 outlet

3 compression means

4 support

5 valve

6 hollow needle

F force

F' counteracting force

V speed