Title:
MEDICAMENT FOR TREATING CANCER
Document Type and Number:
WIPO Patent Application WO/2020/204033
Kind Code:
A1
Abstract:
Provided are a liver cell cancer therapeutic agent, a therapeutic method, etc., which can exhibit more potent and sustained antitumor effects than a conventional multi-kinase inhibitor. The present invention is characterized by including, as a combination medicament for treating liver cell cancer: a lenvatinib or a prodrug thereof, or a pharmaceutically acceptable salt thereof, or a hydrate or solvate thereof; and an antibody against human DLK-1 having an in-vivo anti-tumor activity or antibody fragments derived from said antibody.
Inventors:
NAKAMURA KOJI (JP)
TAKAHASHI KOTA (JP)
SAKAGUCHI IZUMI (JP)
ZHANG LINGYI (JP)
TAKAHASHI KOTA (JP)
SAKAGUCHI IZUMI (JP)
ZHANG LINGYI (JP)
Application Number:
PCT/JP2020/014832
Publication Date:
October 08, 2020
Filing Date:
March 31, 2020
Export Citation:
Assignee:
CHIOME BIOSCIENCE INC (JP)
International Classes:
A61K39/395; A61K31/47; A61K47/68; A61P1/16; A61P35/00; A61P43/00; C07K16/28; C12N15/13
Domestic Patent References:
| WO2014054820A1 | 2014-04-10 | |||
| WO2008056833A1 | 2008-05-15 | |||
| WO2009116670A1 | 2009-09-24 | |||
| WO2014054820A1 | 2014-04-10 |
Foreign References:
| JP2019070120A | 2019-05-09 | |||
| US7612092B2 | 2009-11-03 | |||
| JPH04502408A | 1992-05-07 | |||
| JP2828340B2 | 1998-11-25 |
Other References:
KUDO, MASATOSHI ET AL.: "Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma: a randomised phase ' non-inferiority trial", LANCET, vol. 391, 2018, pages 1163 - 73, XP085366785, DOI: 10.1016/S0140-6736(18)30207-1
KUDO M ET AL., LANCET, vol. 391, no. 10126, 2018, pages 1163 - 1173
"GenBank", Database accession no. NP 003827
"Molecular cloning", 2012, COLD SPRING HARBOR LABORATORY PRESS
PROC. NATL. ACAD. SCI. U.S.A., vol. 81, 1984, pages 6851 - 6855
NATURE, vol. 321, 1986, pages 522 - 525
J. MOL. BIOL., vol. 196, 1987, pages 901 - 917
QUEEN C ET AL., PROC. NATL. ACAD. SCI. USA, vol. 86, 1989, pages 10029 - 10033
REITER ET AL., PROTEIN ENGINEERING, vol. 7, 1994, pages 697 - 704
See also references of EP 3949990A4
KUDO M ET AL., LANCET, vol. 391, no. 10126, 2018, pages 1163 - 1173
"GenBank", Database accession no. NP 003827
"Molecular cloning", 2012, COLD SPRING HARBOR LABORATORY PRESS
PROC. NATL. ACAD. SCI. U.S.A., vol. 81, 1984, pages 6851 - 6855
NATURE, vol. 321, 1986, pages 522 - 525
J. MOL. BIOL., vol. 196, 1987, pages 901 - 917
QUEEN C ET AL., PROC. NATL. ACAD. SCI. USA, vol. 86, 1989, pages 10029 - 10033
REITER ET AL., PROTEIN ENGINEERING, vol. 7, 1994, pages 697 - 704
See also references of EP 3949990A4
Attorney, Agent or Firm:
KOBAYASHI Hiroshi et al. (JP)
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