Title:
MEDICINAL COMPOSITION FOR INHIBITING AMYLOID-Β PROTEIN DEPOSITION
Document Type and Number:
WIPO Patent Application WO/2009/093761
Kind Code:
A1
Abstract:
Provided is a medicinal composition for inhibiting amyloid-β protein
deposition which comprises a compound represented by formula (I) or a pharmaceutically
acceptable salt thereof as the active ingredient. Also provided is a method
for inhibiting amyloid-β protein deposition which comprises a step of
administering an effective amount of a compound represented by formula (I) or
a pharmaceutically acceptable salt thereof to a mammal that is likely diagnosed
as having a disease associated with amyloid-β protein.
(I)
Inventors:
MOTONAGA KOZO (JP)
SAITO KOICHI (JP)
HARADA KOICHIRO (JP)
SAITO KOICHI (JP)
HARADA KOICHIRO (JP)
Application Number:
PCT/JP2009/051522
Publication Date:
July 30, 2009
Filing Date:
January 23, 2009
Export Citation:
Assignee:
SUMITOMO CHEMICAL CO (JP)
MOTONAGA KOZO (JP)
SAITO KOICHI (JP)
HARADA KOICHIRO (JP)
MOTONAGA KOZO (JP)
SAITO KOICHI (JP)
HARADA KOICHIRO (JP)
International Classes:
C07D235/12; A61K31/4184; A61P25/28; A61P43/00
Domestic Patent References:
| WO2004022523A2 | 2004-03-18 | |||
| WO2006042150A1 | 2006-04-20 | |||
| WO2006110477A2 | 2006-10-19 |
Other References:
NG RAYMOND A. ET AL.: "Synthesis of potent and tissue-selective androgen receptor modulators (SARMs):2-(2,2,2)-Trifluoroethyl-benzimidazole scaffold", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 17, 2007, pages 1784 - 1787, XP005895411
VASSAR ROBERT ET AL.: "Abeta-Generating Enzymes: Recent Advances in §- and y-Secretase Reseach", NEURON, vol. 27, 2000, pages 419 - 422, XP002951098
DASH CHANDRAVANU ET AL.: "Aspartic Peptidase Inhibitors: Implications in Drug Development Critical Reviews", BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 38, no. 2, 2003, pages 89 - 119, XP002472134
See also references of EP 2246334A4
NEURON, vol. 27, 2000, pages 419 - 422
VASSAR ROBERT ET AL.: "Abeta-Generating Enzymes: Recent Advances in §- and y-Secretase Reseach", NEURON, vol. 27, 2000, pages 419 - 422, XP002951098
DASH CHANDRAVANU ET AL.: "Aspartic Peptidase Inhibitors: Implications in Drug Development Critical Reviews", BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 38, no. 2, 2003, pages 89 - 119, XP002472134
See also references of EP 2246334A4
NEURON, vol. 27, 2000, pages 419 - 422
Attorney, Agent or Firm:
NAKAYAMA, Tohru et al. (Limited 5-33,Kitahama 4-chome, Chuo-k, Osaka-shi Osaka 50, JP)
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