Title:
MEDICINE FOR KILLING TUMOR CELLS
Document Type and Number:
WIPO Patent Application WO/2021/206078
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a medicine for killing tumor cells, said medicine having few side effects. According to the present invention, provided is a medicine, said medicine comprising a conjugate of a substance capable of binding to a target substance on the surface of tumor cells and a cytotoxin, and a photosensitive dye, and being for killing tumor cells in which the target substance is expressed in a small amount.
Inventors:
TODA NAOKO (JP)
SUDO YUKIO (JP)
HAMAKUBO TAKAO (JP)
SUDO YUKIO (JP)
HAMAKUBO TAKAO (JP)
Application Number:
PCT/JP2021/014588
Publication Date:
October 14, 2021
Filing Date:
April 06, 2021
Export Citation:
Assignee:
PHOTOQ3 INC (JP)
International Classes:
A61K45/00; A61K31/409; A61K38/16; A61K39/395; A61K41/00; A61K47/68; A61P35/00
Domestic Patent References:
| WO1996002576A1 | 1996-02-01 | |||
| WO1993012227A1 | 1993-06-24 | |||
| WO1992003918A1 | 1992-03-19 | |||
| WO1994002602A1 | 1994-02-03 | |||
| WO1994025585A1 | 1994-11-10 | |||
| WO1996034096A1 | 1996-10-31 | |||
| WO1996033735A1 | 1996-10-31 | |||
| WO1992001047A1 | 1992-01-23 | |||
| WO1992020791A1 | 1992-11-26 | |||
| WO1993006213A1 | 1993-04-01 | |||
| WO1993011236A1 | 1993-06-10 | |||
| WO1993019172A1 | 1993-09-30 | |||
| WO1995001438A1 | 1995-01-12 | |||
| WO1995015388A1 | 1995-06-08 |
Foreign References:
| EP0239400A2 | 1987-09-30 | |||
| JPH0159878B2 | 1989-12-20 |
Other References:
OLSEN CATHRINE ELISABETH, CHEUNG LAWRENCE H., WEYERGANG ANETTE, BERG KRISTIAN, VALLERA DANIEL A., ROSENBLUM MICHAEL G., SELBO PÅL : "Design, Characterization, and Evaluation of scFvCD133/rGelonin: A CD133-Targeting Recombinant Immunotoxin for Use in Combination with Photochemical Internalization", JOURNAL OF CLINICAL MEDICINE, vol. 9, no. 1, pages 68, XP055864658, DOI: 10.3390/jcm9010068
YIP WAI LAM, WEYERGANG ANETTE, BERG KRISTIAN, TØNNESEN HANNE H., SELBO PÅL K.: "Targeted Delivery and Enhanced Cytotoxicity of Cetuximab−Saporin by Photochemical Internalization in EGFR-Positive Cancer Cells", MOLECULAR PHARMACEUTICS, vol. 4, no. 2, 1 April 2007 (2007-04-01), US , pages 241 - 251, XP055864663, ISSN: 1543-8384, DOI: 10.1021/mp060105u
WAI LAM YIPANETTE WEYERGANGKRISTIAN SERGHANNE H. TONNESENPAL K. SELBO: "Targeted Delivery and Enhanced Cytotoxicity of Cetuximab-Saporin by Photochemical Internalization in EGFR-Positive Cancer Cells", MOLECULAR PHARMACEUTICS, vol. 4, no. 2, 2007, pages 241 - 251, XP055864663, DOI: 10.1021/mp060105u
KURAI J, CHIKUMI H, HASHIMOTO K, YAMAGUCHI K, YAMASAKI A, SAKO T, TOUGE H, MAKINO H, TAKATA M, MIYATA M, NAKAMOTO M, BURIOKA N, SH: "Antibody-dependent cellular cytotoxicity mediated by cetuximab against lung cancer cell lines", CLIN CANCER RES, vol. 13, no. 5, 2007, pages 1552 - 61, XP002770438, DOI: 10.1158/1078-0432.CCR-06-1726
BERNHARD W1EL-SAYEDALBARRETO KLGONZALEZ CLHILL WLPARADAAC2FONGE HGEYER CRL: "ear infrared fluorescence imaging of EGFR expression in vivo using IRDye800CW-nimotuzumab", ONCOTARGET, vol. 9, no. 5, 2018, pages 6213 - 6227
YIP WAI LAM, WEYERGANG ANETTE, BERG KRISTIAN, TØNNESEN HANNE H., SELBO PÅL K.: "Targeted Delivery and Enhanced Cytotoxicity of Cetuximab−Saporin by Photochemical Internalization in EGFR-Positive Cancer Cells", MOLECULAR PHARMACEUTICS, vol. 4, no. 2, 1 April 2007 (2007-04-01), US , pages 241 - 251, XP055864663, ISSN: 1543-8384, DOI: 10.1021/mp060105u
WAI LAM YIPANETTE WEYERGANGKRISTIAN SERGHANNE H. TONNESENPAL K. SELBO: "Targeted Delivery and Enhanced Cytotoxicity of Cetuximab-Saporin by Photochemical Internalization in EGFR-Positive Cancer Cells", MOLECULAR PHARMACEUTICS, vol. 4, no. 2, 2007, pages 241 - 251, XP055864663, DOI: 10.1021/mp060105u
KURAI J, CHIKUMI H, HASHIMOTO K, YAMAGUCHI K, YAMASAKI A, SAKO T, TOUGE H, MAKINO H, TAKATA M, MIYATA M, NAKAMOTO M, BURIOKA N, SH: "Antibody-dependent cellular cytotoxicity mediated by cetuximab against lung cancer cell lines", CLIN CANCER RES, vol. 13, no. 5, 2007, pages 1552 - 61, XP002770438, DOI: 10.1158/1078-0432.CCR-06-1726
BERNHARD W1EL-SAYEDALBARRETO KLGONZALEZ CLHILL WLPARADAAC2FONGE HGEYER CRL: "ear infrared fluorescence imaging of EGFR expression in vivo using IRDye800CW-nimotuzumab", ONCOTARGET, vol. 9, no. 5, 2018, pages 6213 - 6227
Attorney, Agent or Firm:
SIKS & CO. (JP)
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