Title:
MEDICINE FOR PREVENTING AND/OR TREATING STRESS LOAD-RELATED DISEASE
Document Type and Number:
WIPO Patent Application WO/2020/045683
Kind Code:
A1
Abstract:
The present invention pertains to a medicine, said medicine comprising as an active ingredient a substance which suppresses the expression of at least one molecule selected from the group consisting of TMEM5, VSTM2L, C2CD4D, VSTM2A, LY6G6C and ADRA2C or inhibits the activity thereof, for preventing and/or treating at least one disease or symptom selected from the group consisting of progressive multiple sclerosis, gastroenteritis, myocardial disorder and sudden death. Also, the present invention pertains to a method for screening a substance, which is capable of preventing and/or treating at least one disease or symptom selected from the group consisting of progressive multiple sclerosis, gastroenteritis, myocardial disorder and sudden death, with the use of the expression or activity of the aforesaid molecule as an index.
Inventors:
MURAKAMI MASAAKI (JP)
KAMIMURA DAISUKE (JP)
KAMIMURA DAISUKE (JP)
Application Number:
PCT/JP2019/034497
Publication Date:
March 05, 2020
Filing Date:
September 02, 2019
Export Citation:
Assignee:
UNIV HOKKAIDO NAT UNIV CORP (JP)
International Classes:
A61K45/00; A61K31/7088; A61K39/395; A61K48/00; A61P1/04; A61P9/00; A61P25/00; G01N33/15
Domestic Patent References:
| WO2018034334A1 | 2018-02-22 | |||
| WO2016131944A1 | 2016-08-25 | |||
| WO2008058018A2 | 2008-05-15 | |||
| WO2018159787A1 | 2018-09-07 |
Foreign References:
| JP2016500651A | 2016-01-14 | |||
| JP2001519154A | 2001-10-23 | |||
| CN106544430A | 2017-03-29 | |||
| JP2014071016A | 2014-04-21 | |||
| JP2014534957A | 2014-12-25 | |||
| JP2018007901W | 2018-03-01 |
Other References:
YASUNOBU ARIMA, TAKUTO OHKI, NAOKI NISHIKAWA, KOTARO HIGUCHI, MITSUTOSHI OTA, YUKI TANAKA, JUNKO NIO-KOBAYASHI, MOHAMED ELFEKY, RY: "Brain micro-inflammation at specific vessels dysregulates organ-homeostasis via the activation of a new neural circuit", ELIFE, vol. 6, 15 August 2017 (2017-08-15), pages 1 - 27, XP055695430, ISSN: 2050-084X, DOI: 10.7554/eLife.25517
LARA ROSSINI, YUICHI HASHIMOTO, HIROAKI SUZUKI, MEGUMI KURITA, MARCO GIANFRIDDO, CARLA SCALI, RENZA RONCARATI, DAVIDE FRANCESCHINI: "VSTM2L is a novel secreted antagonist of the neuroprotective peptide Humanin", THE FASEB JOURNAL, vol. 25, no. 6, 1 June 2011 (2011-06-01), pages 1983 - 2000, XP055695428, ISSN: 0892-6638, DOI: 10.1096/fj.10-163535
DONG YUJUAN,KANG WEI,ZHANG YANQUAN,NG SIU MAN SIMON,YU JUN: "Secretion protein VSTM2A is a novel tumor suppressor and associates with colorectal cancer patient survival", UNITED EUROPEAN GASTROENTEROL JOURNAL , vol. 4, no. 5, 15 October 2016 (2016-10-15), pages A280 - A281, XP055791736, ISSN: 2050-6406
BLANDINE SECCO, ETIENNE CAMIRE, MARC-ANTOINE BRIERE, ALEXANDRE CARON, ARMANDE BILLONG, YVES GELINAS, ANNE-MARIE LEMAY, KEVIN M. TH: "Amplification of Adipogenic Commitment by VSTM2A", CELL REPORTS, vol. 18, no. 1, 1 January 2017 (2017-01-01), pages 93 - 106, XP055695426, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2016.12.015
CASO, J. R. ET AL., CURRENT MOLECULAR MEDICINE, vol. 8, 2008, pages 299 - 312
ARIMA, Y. ET AL., ELIFE, vol. 4, 2015, pages e08733
ARIMA, Y. ET AL., ELIFE, vol. 6, 2017, pages e25517
"GenBank", Database accession no. XP _016874176.1, and XP 005268620.1
MIYAZAKI, K. ET AL., PLOS ONE, vol. 8, 2013, pages e55452
ARIMA, Y. ET AL., CELL., vol. 148, 2012, pages 447 - 457
OGURA, H. ET AL., IMMUNITY, vol. 29, 2008, pages 628 - 636
ARIMA, Y. ET AL., CELL, vol. 148, 2012, pages 447 - 457
See also references of EP 3845246A4
LARA ROSSINI, YUICHI HASHIMOTO, HIROAKI SUZUKI, MEGUMI KURITA, MARCO GIANFRIDDO, CARLA SCALI, RENZA RONCARATI, DAVIDE FRANCESCHINI: "VSTM2L is a novel secreted antagonist of the neuroprotective peptide Humanin", THE FASEB JOURNAL, vol. 25, no. 6, 1 June 2011 (2011-06-01), pages 1983 - 2000, XP055695428, ISSN: 0892-6638, DOI: 10.1096/fj.10-163535
DONG YUJUAN,KANG WEI,ZHANG YANQUAN,NG SIU MAN SIMON,YU JUN: "Secretion protein VSTM2A is a novel tumor suppressor and associates with colorectal cancer patient survival", UNITED EUROPEAN GASTROENTEROL JOURNAL , vol. 4, no. 5, 15 October 2016 (2016-10-15), pages A280 - A281, XP055791736, ISSN: 2050-6406
BLANDINE SECCO, ETIENNE CAMIRE, MARC-ANTOINE BRIERE, ALEXANDRE CARON, ARMANDE BILLONG, YVES GELINAS, ANNE-MARIE LEMAY, KEVIN M. TH: "Amplification of Adipogenic Commitment by VSTM2A", CELL REPORTS, vol. 18, no. 1, 1 January 2017 (2017-01-01), pages 93 - 106, XP055695426, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2016.12.015
CASO, J. R. ET AL., CURRENT MOLECULAR MEDICINE, vol. 8, 2008, pages 299 - 312
ARIMA, Y. ET AL., ELIFE, vol. 4, 2015, pages e08733
ARIMA, Y. ET AL., ELIFE, vol. 6, 2017, pages e25517
"GenBank", Database accession no. XP _016874176.1, and XP 005268620.1
MIYAZAKI, K. ET AL., PLOS ONE, vol. 8, 2013, pages e55452
ARIMA, Y. ET AL., CELL., vol. 148, 2012, pages 447 - 457
OGURA, H. ET AL., IMMUNITY, vol. 29, 2008, pages 628 - 636
ARIMA, Y. ET AL., CELL, vol. 148, 2012, pages 447 - 457
See also references of EP 3845246A4
Attorney, Agent or Firm:
IP-ASSIST PATENT OFFICE (JP)
Download PDF: