Title:
MEDICINE FOR TREATING CANCER
Document Type and Number:
WIPO Patent Application WO/2024/024923
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a medicine that promotes DNA damage caused by radiation in malignant tumor (cancer) cells while suppressing DNA damage caused by radiation in normal cells. The present invention provides a medicine for promoting DNA damage caused by radiation in malignant tumor (cancer) cells while suppressing DNA damage caused by radiation in normal cells, the medicine comprising nicaraven as an active ingredient.
Inventors:
FUJITA YUHZO (JP)
ICHIMIYA KAZUKO (JP)
CHIBA NATSUKO (JP)
JINGU KEIICHI (JP)
YOSHINO YUKI (JP)
ICHIMIYA KAZUKO (JP)
CHIBA NATSUKO (JP)
JINGU KEIICHI (JP)
YOSHINO YUKI (JP)
Application Number:
PCT/JP2023/027683
Publication Date:
February 01, 2024
Filing Date:
July 28, 2023
Export Citation:
Assignee:
SCIENCE TECH INTERACT CO LTD (JP)
UNIV TOHOKU (JP)
UNIV TOHOKU (JP)
International Classes:
A61K31/455; A61P35/00; A61P39/00; A61P39/06; A61P43/00; C12N9/10; C12N15/09
Foreign References:
| JP2017218380A | 2017-12-14 | |||
| JPH06145057A | 1994-05-24 |
Other References:
LI TAO-SHENG: "Development of drug that both reduce radiation treatment side effects and suppress cancer metastasis", GRANTS-IN-AID FOR SCIENTIFIC RESEARCH FINA RESEARCH REPORT, PROJECT NO: 17HO4265, 28 May 2020 (2020-05-28), XP093133514, Retrieved from the Internet
YAN, CHEN ET AL.: "Nicaraven is effective in reducing side effects of cancer radiotherapy", JOURNAL OF HIROSHIMA MEDICAL ASSOCIATION, vol. 71, no. 4, 1 April 2018 (2018-04-01), JAPAN , pages 368 - 369, XP009552750, ISSN: 0367-5904
MORI, YASUTANE ET AL.: "Examination of the usefulness of nicaraben as a radioprotective agent", JOURNAL OF OKAYAMA MEDICAL ASSOCIATION, vol. 105, no. 7-8, 1 January 1993 (1993-01-01), JP , pages 673 - 680, XP009552752, ISSN: 0030-1558, DOI: 10.4044/joma1947.105.7-8_673
ABDELGHANY LINA; ZHANG XU; KAWABATA TSUYOSHI; GOTO SHINJI; EL-MAHDY NAGEH; JINGU KEIICHI; LI TAO-SHENG: "Nicaraven prevents the fast growth of inflamed tumors by an anti-inflammatory mechanism", MEDICAL ONCOLOGY, SCIENCE AND TECHNOLOGY LETTERS, NORTHWOOD, GB, vol. 39, no. 1, 10 November 2021 (2021-11-10), GB , XP037664703, ISSN: 1357-0560, DOI: 10.1007/s12032-021-01602-x
MORI, YASUTANE; TAKASHIMA, HITOSHI; SEO, HIROYUKI; YAMAMOTO, GOKI; LIU, JIANKANG; OHKAWA, MOTOOMI; TANABE, MASATADA: "Experimental studies of nicaraben as radioprotector - Free radical scavenging effect and the inhibition of cellular injury - ", JOURNAL OF JAPAN RADIOLOGICAL SOCIETY, vol. 53, no. 6, 1 January 1993 (1993-01-01), JP , pages 704 (84) - 712 (92), XP009552753, ISSN: 0048-0428
XU YONG, ZHAI DA, GOTO SHINJI, ZHANG XU, JINGU KEIICHI, LI TAO-SHENG: "Nicaraven mitigates radiation-induced lung injury by downregulating the NF-κB and TGF-β/Smad pathways to suppress the inflammatory response", JOURNAL OF RADIATION RESEARCH, JAPAN RADIATION RESEARCH SOCIETY, TOKYO, JP, vol. 63, no. 2, 17 March 2022 (2022-03-17), JP , pages 158 - 165, XP093133519, ISSN: 0449-3060, DOI: 10.1093/jrr/rrab112
ROSE MADDISON, BURGESS JOSHUA T., O’BYRNE KENNETH, RICHARD DEREK J., BOLDERSON EMMA: "PARP Inhibitors: Clinical Relevance, Mechanisms of Action and Tumor Resistance", FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, vol. 8, 564601, 2020, XP093052204, DOI: 10.3389/fcell.2020.564601
WATANABE MICHIKO, AKIYAMA NOBUTAKE, SEKINE HIROSHI, MORI MARIKO, MANOME YOSHINOBU: "Inhibition of Poly (ADP-ribose) Polymerase as a Protective Effect of Nicaraven in Ionizing Radiation- and Ara-C-induced Cell Death", ANTICANCER RESEARCH, INTERNATIONAL INSTITUTE OF ANTICANCER RESEARCH, GR, vol. 26, no. 5A, 1 September 2006 (2006-09-01), GR , pages 3421 - 3427, XP093133562, ISSN: 0250-7005
YAN, CHEN ET AL.: "Nicaraven is effective in reducing side effects of cancer radiotherapy", JOURNAL OF HIROSHIMA MEDICAL ASSOCIATION, vol. 71, no. 4, 1 April 2018 (2018-04-01), JAPAN , pages 368 - 369, XP009552750, ISSN: 0367-5904
MORI, YASUTANE ET AL.: "Examination of the usefulness of nicaraben as a radioprotective agent", JOURNAL OF OKAYAMA MEDICAL ASSOCIATION, vol. 105, no. 7-8, 1 January 1993 (1993-01-01), JP , pages 673 - 680, XP009552752, ISSN: 0030-1558, DOI: 10.4044/joma1947.105.7-8_673
ABDELGHANY LINA; ZHANG XU; KAWABATA TSUYOSHI; GOTO SHINJI; EL-MAHDY NAGEH; JINGU KEIICHI; LI TAO-SHENG: "Nicaraven prevents the fast growth of inflamed tumors by an anti-inflammatory mechanism", MEDICAL ONCOLOGY, SCIENCE AND TECHNOLOGY LETTERS, NORTHWOOD, GB, vol. 39, no. 1, 10 November 2021 (2021-11-10), GB , XP037664703, ISSN: 1357-0560, DOI: 10.1007/s12032-021-01602-x
MORI, YASUTANE; TAKASHIMA, HITOSHI; SEO, HIROYUKI; YAMAMOTO, GOKI; LIU, JIANKANG; OHKAWA, MOTOOMI; TANABE, MASATADA: "Experimental studies of nicaraben as radioprotector - Free radical scavenging effect and the inhibition of cellular injury - ", JOURNAL OF JAPAN RADIOLOGICAL SOCIETY, vol. 53, no. 6, 1 January 1993 (1993-01-01), JP , pages 704 (84) - 712 (92), XP009552753, ISSN: 0048-0428
XU YONG, ZHAI DA, GOTO SHINJI, ZHANG XU, JINGU KEIICHI, LI TAO-SHENG: "Nicaraven mitigates radiation-induced lung injury by downregulating the NF-κB and TGF-β/Smad pathways to suppress the inflammatory response", JOURNAL OF RADIATION RESEARCH, JAPAN RADIATION RESEARCH SOCIETY, TOKYO, JP, vol. 63, no. 2, 17 March 2022 (2022-03-17), JP , pages 158 - 165, XP093133519, ISSN: 0449-3060, DOI: 10.1093/jrr/rrab112
ROSE MADDISON, BURGESS JOSHUA T., O’BYRNE KENNETH, RICHARD DEREK J., BOLDERSON EMMA: "PARP Inhibitors: Clinical Relevance, Mechanisms of Action and Tumor Resistance", FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, vol. 8, 564601, 2020, XP093052204, DOI: 10.3389/fcell.2020.564601
WATANABE MICHIKO, AKIYAMA NOBUTAKE, SEKINE HIROSHI, MORI MARIKO, MANOME YOSHINOBU: "Inhibition of Poly (ADP-ribose) Polymerase as a Protective Effect of Nicaraven in Ionizing Radiation- and Ara-C-induced Cell Death", ANTICANCER RESEARCH, INTERNATIONAL INSTITUTE OF ANTICANCER RESEARCH, GR, vol. 26, no. 5A, 1 September 2006 (2006-09-01), GR , pages 3421 - 3427, XP093133562, ISSN: 0250-7005
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
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