Title:
MEDICINE FOR TREATING OR PREVENTING DISEASES RELATED TO ACTIVITY OF LRRK2 KINASE OR ABNORMAL LRRK2 MUTANT KINASE
Document Type and Number:
WIPO Patent Application WO/2022/062357
Kind Code:
A1
Abstract:
A medicine for treating or preventing diseases related to the activity of an LRRK2 kinase or an abnormal LRRK2 mutant kinase, which belongs to the field of medicine. The medicine comprises at least one of a compound represented by chemical formula 1, an optical isomer, a prodrug, a salt, a hydrate, a solvate, an N-oxide and a deuterated analog thereof, has a very good inhibition effect on the LRRK2 kinase or abnormal LRRK2 mutant kinase, and can be used for treating or preventing diseases related to the activity of the LRRK2 kinase or abnormal LRRK2 mutant kinase, such as Alzheimer's disease, L-dopa-induced dyskinesia, Parkinson's disease, dementia, kidney cancer, breast cancer, prostate cancer, leukemia, papilloma, lung cancer, acute myeloid leukemia, multiple myeloma, leprosy, Crohn's disease, inflammatory bowel disease, ulcerative colitis, amyotrophic lateral sclerosis, rheumatoid arthritis or ankylosing spondylitis.
Inventors:
XIE WEIDONG (CN)
CHENG XING (CN)
CHENG XING (CN)
Application Number:
PCT/CN2021/084889
Publication Date:
March 31, 2022
Filing Date:
April 01, 2021
Export Citation:
Assignee:
DM INTELLIGENCE LTD (CN)
International Classes:
A61K31/404; A61K31/519; A61K31/433; A61K31/454; A61K31/4709; A61K31/5377; A61K31/708; A61P1/00; A61P19/02; A61P19/08; A61P21/00; A61P25/00; A61P25/14; A61P25/16; A61P25/28; A61P29/00; A61P35/00; A61P35/02; A61P37/06
Domestic Patent References:
| WO2018171819A1 | 2018-09-27 |
Foreign References:
| CN112043710A | 2020-12-08 | |||
| CN103958510A | 2014-07-30 | |||
| CN103703000A | 2014-04-02 | |||
| CN103012428A | 2013-04-03 | |||
| CN108338985A | 2018-07-31 |
Other References:
WAN, Y. C. ET AL.: "Indole: A privileged scaffold for the design of anti-cancer agents.", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY., vol. 183, 11 September 2019 (2019-09-11), XP085892889, DOI: 10.1016/j.ejmech.2019.111691
SMITH GARRICK P., LASSINA BADOLO, VICTORIA CHELL, I-JEN CHEN, KENNETH VIELSTED CHRISTENSEN, LAURENT DAVID, JUSTUS ALFRED DAECHSEL,: "The design and SAR of a novel series of 2-aminopyridine based LRRK2 inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 27, 1 August 2017 (2017-08-01), pages 4500 - 4505, XP055914545, DOI: 10.1016/j.bmcl.2017.07.072
SMITH GARRICK P., LASSINA BADOLO, VICTORIA CHELL, I-JEN CHEN, KENNETH VIELSTED CHRISTENSEN, LAURENT DAVID, JUSTUS ALFRED DAECHSEL,: "The design and SAR of a novel series of 2-aminopyridine based LRRK2 inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 27, 1 August 2017 (2017-08-01), pages 4500 - 4505, XP055914545, DOI: 10.1016/j.bmcl.2017.07.072
Attorney, Agent or Firm:
SCIHEAD IP LAW FIRM (CN)
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