Title:
MEDICINE FOR TREATMENT AND/OR PREVENTION OF DEPRESSION AND/OR DEPRESSIVE STATE
Document Type and Number:
WIPO Patent Application WO/2023/162987
Kind Code:
A1
Abstract:
Provided are a medicine, a medicinal composition, and a method for the treatment, assistance in treatment, and/or prevention of depression and/or a depressive state, characterized by combining ketamine or a pharmaceutically acceptable salt thereof and aripiprazole or a pharmaceutically acceptable salt thereof.
Inventors:
MURAI TOSHIYA (JP)
YAMAKAWA HIDEKUNI (JP)
NAKATSUKA DAIKI (JP)
SUWA TARO (JP)
YAMAKAWA HIDEKUNI (JP)
NAKATSUKA DAIKI (JP)
SUWA TARO (JP)
Application Number:
PCT/JP2023/006264
Publication Date:
August 31, 2023
Filing Date:
February 21, 2023
Export Citation:
Assignee:
UNIV KYOTO (JP)
International Classes:
A61K31/13; A61K31/496; A61P25/24; A61P43/00
Domestic Patent References:
| WO2013138322A1 | 2013-09-19 |
Other References:
AKIL OEZNUR, MELTEM GÖBELEK, İSMAIL KARKA, FARUK PIRINÇÇIOĞLU, ÖZLEM BEĞINOĞLU, MEHMET ASOĞLU: "Administration of ketamine infusion in unipolar depression", PSYCHIATRY AND CLINICAL PSYCHOPHARMACOLOGY, vol. 28, no. 1, 1 January 2018 (2018-01-01), pages 241, XP093088115, ISSN: 2475-0581
MCINNES, A. L. ET AL.: "Possible Affective Switch Associated With Intravenous Ketamine Treatment in a Patient With Bipolar I Disorder", BIOLOGICAL PSYCHIATRY, vol. 79, no. 9, 2016, pages e71 - e72, XP029500075, ISSN: 0006-3223, DOI: 10.1016/j.biopsych.2015.07.003
ESTAPHAN SUZANNE, CURPĂN ALEXANDRINA-STEFANIA, KHALIFA DALIA, RASHED LAILA, CIOBICA ANDREI, CANTEMIR ADRIAN, CIOBICA ALIN, TRUS CO: "Combined Low Dose of Ketamine and Social Isolation: A Possible Model of Induced Chronic Schizophrenia-Like Symptoms in Male Albino Rats", BRAIN SCIENCES, vol. 11, no. 7, pages 917, XP093088116, DOI: 10.3390/brainsci11070917
LEITE, J. V.: "Aripiprazole, an atypical antipsychotic, prevents the motor hyperactivity induced by psychotomimetics and psychostimulants in mice", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 578, no. 2-3, 2008, pages 222 - 227, XP022405024, ISSN: 1879-0712, DOI: 10.1016/j.ejphar.2007.09.016
FASIPE OLUMUYIWA JOHN: "The emergence of new antidepressants for clinical use: Agomelatine paradox versus other novel agents", IBRO REPORTS, vol. 6, 1 June 2019 (2019-06-01), pages 95 - 110, XP093088117, ISSN: 2451-8301, DOI: 10.1016/j.ibror.2019.01.001
MCINNES, A. L. ET AL.: "Possible Affective Switch Associated With Intravenous Ketamine Treatment in a Patient With Bipolar I Disorder", BIOLOGICAL PSYCHIATRY, vol. 79, no. 9, 2016, pages e71 - e72, XP029500075, ISSN: 0006-3223, DOI: 10.1016/j.biopsych.2015.07.003
ESTAPHAN SUZANNE, CURPĂN ALEXANDRINA-STEFANIA, KHALIFA DALIA, RASHED LAILA, CIOBICA ANDREI, CANTEMIR ADRIAN, CIOBICA ALIN, TRUS CO: "Combined Low Dose of Ketamine and Social Isolation: A Possible Model of Induced Chronic Schizophrenia-Like Symptoms in Male Albino Rats", BRAIN SCIENCES, vol. 11, no. 7, pages 917, XP093088116, DOI: 10.3390/brainsci11070917
LEITE, J. V.: "Aripiprazole, an atypical antipsychotic, prevents the motor hyperactivity induced by psychotomimetics and psychostimulants in mice", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 578, no. 2-3, 2008, pages 222 - 227, XP022405024, ISSN: 1879-0712, DOI: 10.1016/j.ejphar.2007.09.016
FASIPE OLUMUYIWA JOHN: "The emergence of new antidepressants for clinical use: Agomelatine paradox versus other novel agents", IBRO REPORTS, vol. 6, 1 June 2019 (2019-06-01), pages 95 - 110, XP093088117, ISSN: 2451-8301, DOI: 10.1016/j.ibror.2019.01.001
Attorney, Agent or Firm:
YAMAO, Norihito et al. (JP)
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