Title:
MEDIUM AND METHOD FOR PREPARATION OF SALIVARY GLAND ORGANOID
Document Type and Number:
WIPO Patent Application WO/2024/076182
Kind Code:
A1
Abstract:
The present invention relates to a medium composition for preparing a salivary gland organoid. Also, the present invention relates to: a method for preparing a salivary gland organoid, comprising a step of culturing salivary gland-derived cells in the medium composition; and a salivary gland organoid prepared by the preparation method. A medium for preparing a salivary gland organoid, according to the present invention, can promote the proliferation of a salivary gland organoid, maintain the stemness of the salivary gland organoid, and increase engraftment capability. Therefore, the medium can be used to prepare a large amount of salivary gland organoids with excellent quality, and salivary gland organoids prepared using the medium can be used as a preventive or therapeutic agent for salivary gland-related diseases, an alternative to animal experimental models for salivary gland-related diseases, or the like.
Inventors:
LEE JAESEON (KR)
SEO JAEHWI (KR)
CHOI JINKYOUNG (KR)
KIM YEEUN (KR)
SEO JAEHWI (KR)
CHOI JINKYOUNG (KR)
KIM YEEUN (KR)
Application Number:
PCT/KR2023/015359
Publication Date:
April 11, 2024
Filing Date:
October 05, 2023
Export Citation:
Assignee:
ORGANOIDSCIENCES LTD (KR)
International Classes:
C12N5/071; A61K35/55; A61P1/02
Foreign References:
| KR20220050548A | 2022-04-25 | |||
| KR20130131815A | 2013-12-04 | |||
| US20170275592A1 | 2017-09-28 | |||
| KR102573391B1 | 2023-09-01 |
Other References:
S. YOSHIMOTO: "Inhibition of Alk signaling promotes the induction of human salivary gland-derived organoids", DISEASE MODELS & MECHANISMS, THE COMPANY OF BIOLOGISTS LTD., GB, vol. 13, 1 January 2020 (2020-01-01), GB , XP093154260, ISSN: 1754-8403, DOI: 10.1242/dmm.045054
YOON YEO-JUN, KIM DONGHYUN, TAK KWON YONG, HWANG SEUNGYEON, KIM JISUN, SIM NAM SUK, CHO JAE-MIN, CHOI DOJIN, JI YONGMI, HUR JUNHO : "Salivary gland organoid culture maintains distinct glandular properties of murine and human major salivary glands", NATURE COMMUNICATIONS, vol. 13, no. 1, XP093073620, DOI: 10.1038/s41467-022-30934-z
YOON YEO-JUN, KIM DONGHYUN, TAK KWON YONG, HWANG SEUNGYEON, KIM JISUN, SIM NAM SUK, CHO JAE-MIN, CHOI DOJIN, JI YONGMI, HUR JUNHO : "Salivary gland organoid culture maintains distinct glandular properties of murine and human major salivary glands", NATURE COMMUNICATIONS, vol. 13, no. 1, XP093073620, DOI: 10.1038/s41467-022-30934-z
Attorney, Agent or Firm:
IPSCENT (KR)
Download PDF: