MELT-STABILIZED ULTRA HIGH MOLECULAR WEIGHT POLYETHYLENE

CROSS-REFERENCE TO RELATED APPLICATION

[0001] This application claims the benefit of priority to U.S. Provisional Patent

Application Serial No. 62/138,081 filed March 25, 2015, the disclosure of which is incorporated herein in its entirety by reference.

BACKGROUND

[0002] Ultra high molecular weight polyethylene (UHMWPE) is a unique form of polyethylene of extremely high molecular weight, where the molecular weight of commercial grade materials are typically in the range of 2 to 7 million. The molecular weight of commodity polyethylene is typically in the range of 50,000 to 00,000, a factor of 25 or more times lower. UHMWPE is the most widely used material for orthopedic implants that articulate, such as for hip, knee, ankle, elbow and shoulder joint replacement due to osteoarthritis. First implemented in the early 1960's, a major concern for this material has been high wear rate with generation of microscopic wear particles over years of articulation. A known outcome of a high polyethylene particulate burden is a condition known as osteolysis, which results in implant loosening with subsequent need for revision surgery. This concern was addressed in the late 1990's with the introduction of highly crosslinked UHMWPE, which is crosslinked by the use of high energy irradiation such as gamma or electron beam. Crossiinking reduces the wear rate of UHMWPE significantly, but also leaves a high free radical burden in the polyethylene which, if not reduced, can cause oxidation in-vivo, with subsequent reduction in mechanical properties, increasing wear rates, and potential implant failure.

[0003] To address the free radical burden, highly crosslinked UHMWPE is most often heat stabilized by raising the material temperature above the melting point of the material. This allows the trapped free radicals that did not participate in crossiinking to promote further crossiinking in the material, or to re-combine, rendering them to an inert state that will not promote premature oxidative degradation. However, the melting process can cause the formation of a significant oxidized layer on the exterior of the material if the melting process is done in an oxygen-containing environment such as air, where sufficient oxygen is present to diffuse into the material in the molten state. This oxidized layer is removed during fabrication of the implant to prevent contamination of the implant with oxidatively-degraded UHMWPE.

SUMMARY OF THE INVENTION

0004] In various embodiments, the present invention provides a method of melt- stabilizing ultra high molecular weight polyethylene (UHMWPE). The method includes coating a solid material including UHMWPE with an antioxidant, to provide an antioxidant-coated solid material. The method includes pre-irradiatively heating the antioxidant-coated solid material to diffuse the antioxidant therein, to provide an antioxidant-diffused solid material. The method includes irradiating the antioxidant-diffused soiid material, to provide an irradiated solid material. The method includes post-irradiatively heating the irradiated solid material, the heating sufficient to melt at least part of the UHMWPE, to provide a heated material. The method includes solidifying the heated material, to provide a melt-stabilized material.

[0005] In various embodiments, the present invention provides a method of melt- stabilizing ultra high molecular weight polyethylene (UHMWPE). The method includes coating a solid material including UHMWPE with a protected vitamin E antioxidant, to provide an antioxidant-coated solid material. The protected vitamin E antioxidant is at least one of at least one of (a) and (b). Protected vitamin E antioxidant (a) is a protected tocopherol or tocotrienol having the structure: r a salt thereof or

OR' , or a salt thereof.

At each occurrence, R ^a is independently chosen from -H, -E, and substituted or unsubstituted (Ci-Cio)hydrocarbyl . The variable E has the structure: r

The variables R ^? , R ^s , and R ⁹ are each independently chosen from -H, substituted or unsubstituted (Ci-Cio)alkyi, and substituted or unsubstituted (Ci-Cio)aikenyl. Protected vitamin E antioxidant (b) i s a hindered amine stabilizer-protected toco herol or tocotrienol of formula (I):

(I)

or a salt thereof. The variables R ¹ , R ² , R ³ , and R ⁴ are each, independently, hydrogen or (Ci- Cio)alkyl. The variable R ⁵ is chosen from hydrogen, (Ci-Cio)alkyl, -()·, and -OR ¹¹ wherein R ^{! !} is hydrogen or (Ci-Cio)alkyl. The variable Y represents the group:

The variable R ⁶ is hydrogen, (Ci-Cio)alky -E, or a radical of the formula:

The method includes pre-irradiatively heating the antioxidant-coated solid material to diffuse the antioxidant therein, to provide an antioxidant-diffused solid material. The method includes irradiating the antioxidant-diffused solid material, to provide an irradiated solid material. The method includes post-irradiatively heating the irradiated solid material, the heating sufficient to melt at least part of the UHMWPE, to provide a heated material. The method also includes solidifying the heated material, to provide a melt-stabilized material.

[0006] In various embodiments, the present invention provides a melt-stabilized ultra high molecular weight polyethylene (UHMWPE) material made by a method including coating a solid material including UHMWPE with an antioxidant, to provide an antioxidant-coated solid material. The method includes pre-irradiatively heating the antioxidant-coated solid material to diffuse the antioxidant therein, to provide an antioxidant-diffused solid material. The method includes irradiating the antioxidant-diffused solid material, to provide an irradiated solid material. The method includes post-irradiatively heating the irradiated solid material, the heating sufficient to melt at least part of the UHMWPE, to provide a heated material. The method also includes solidifying the heated material, to provide the melt-stabilized material.

[0007] Various embodiments of the present invention provide certain advantages over other melt-stabilized ultra high molecular weight polyethylenes and methods of making the same. In some embodiments, the method can include forming a UHMWPE material having less or no formation of an oxidized layer on the surface of the UHMWPE. Medical-grade UHMWPE can represent a signifi cant cost in the production of a medical implant including UHMWPE. Oxidation of the surface of UHMWPE during various steps, such as during melt-stabilization (e.g., melting after irradiation), results in the removal and discarding of the oxidized layer due to unsuitability for medical-implant preparation. In some embodiments, as compared to other techniques for preparing UHMWPE materials, the method can form a UHMWPE material that is ready to form into a medical implant with less or no removal of a surface layer. In various embodiments, by avoiding or decreasing removal of an oxidized surface layer of UHWMPE, the method provides cost savings over other methods by decreasing the amount of UHMWPE that is wasted. In some embodiments, the method can avoid formation of a surface oxidation layer even with melt-stabilization in an oxygen-containing atmosphere (e.g., air). In various embodiments, as compared to techniques using an oxygen-free or oxygen-depleted environment for melt- stabilization, the method provides costs savings by avoiding equipment, supplies, and time- consuming techniques needed for generating an oxygen-free or oxygen-depleted environment. In various embodiments, performing the method using a protected antioxidant provides a melt- stabilized crosslinked UHMWPE with a higher crosslinking density than other UHMWPEs with pre-irradiative addition of antioxidant, but having similar or greater post-irradiative resistance to oxidation and corresponding degradation.

[0008] In various embodiments, the addition and diffusion of the antioxidant can be more convenient and can reduce processing costs as well as reducing costs related to oxidation. For example, in various embodiments, diffusion of the antioxidant can be conducting during a consolidation process in situ, such as for semi -continuous processes such as ram extrusion or continuous processes such as extrusion, in various embodiments, the antioxidant can be applied to the material after consolidation of powder in an external layer.

[0009] In various embodiments, in addition to providing oxidative resistance to the implant, diffusion of the antioxidant in an external layer of material can retard or lower infusion of lipids in vivo that may promote oxidation of UHMWPE.

[0010] In various embodiments, the method can include targeting antioxidants that can retard crosslinking to regions of an implant that require higher mechanical property retention and that may not require the higher wear resistance provided by a higher crosslinking density.

Articulation can be lower or minimal in a region not requiring high wear resistance; for example, the rim of a hip implant liner can be subjected to low wear rates but is subjected to oxidative stresses and can require high mechanical property retention.

DETAILED DESCRIPTION OF THE INVENTION

[0011] Reference will now be made in detail to certain embodiments of the disclosed subject matter. While the disclosed subject matter will be described in conjunction with the enumerated claims, it will be understood that the exemplified subject matter is not intended to limit the claims to the disclosed subject matter.

[0012] Throughout this document, values expressed in a range format should be interpreted in a flexible manner to include not only the numerical values explicitly recited as the limits of the range, but also to include all the individual numerical values or sub-ranges encompassed within that range as if each numerical value and sub-range is explicitly recited. For example, a range of "about 0.1% to about 5%" or "about 0.1% to 5%" should be interpreted to include not just about 0.1% to about 5%, but also the individual values (e.g., 1%, 2%, 3%, and 4%) and the sub-ranges (e.g., 0.1% to 0.5%, 1.1% to 2.2%, 3.3% to 4.4%) within the indicated range. The statement "about X to Y" has the same meaning as "about X to about Y," unless indicated otherwise. Likewise, the statement "about X, Y, or about Z" has the same meaning as "about X, about Y, or about Z," unless indicated otherwise.

[0013] In this document, the terms "a," "an," or "the" are used to include one or more than one unless the context clearly dictates otherwise. The term "or" is used to refer to a nonexclusive "or" unless otherwise indicated. The statement "at least one of A and B" has the same meaning as "A, B, or A and B." In addition, it is to be understood that the phraseology or terminology employed herein, and not otherwise defined, is for the purpose of description only and not of limitation. Any use of section headings is intended to aid reading of the document and is not to be interpreted as limiting; information that is relevant to a section heading may occur within or outside of that particular section. A comma can be used as a delimiter or digit group separator to the left or right of a decimal mark, for example, "0.000, 1" is equivalent to "0.0001."

[0014] In the methods described herein, the acts can be carried out in any order without departing from the principles of the invention, except when a temporal or operational sequence is explicitly recited. Furthermore, specified acts can be carried out concurrently unless explicit claim language recites that they be carried out separately. For example, a claimed act of doing X and a claimed act of doing Y can be conducted simultaneously within a single operation, and the resulting process will fall within the literal scope of the claimed process,

[0015] The term "about" as used herein can allow for a degree of variability in a value or range, for example, within 10%, within 5%, or within 1 % of a stated value or of a stated limit of a range, and includes the exact stated value or range.

[0016] The term "substantially" as used herein refers to a majority of or mostly, as in at least about 50%, 60%, 70%, 80%, 90%, 95%, 96%, 97%, 98%, 99%, 99.5%, 99.9%, 99.99%, or at least about 99.999% or more, or 1.00%.

[0017] The term "organic group" as used herein refers to any carbon-containing functional group. For example, an oxygen-containing group such as an alkoxy group, aryloxy group, aralkyloxy group, oxo(carbonyl) group, a carboxyl group including a carboxylic acid, carboxylate, and a carboxylate ester; a sulfur-containing group such as an alkyl and aryl sulfide group; and other heteroatom-containing groups. Non-limiting examples of organic groups include OR, OOR, QC(0)N(R) ₂ , CN, CF ₃ , OCF3, R, C(O), methylenedioxy, ethylenedioxy, N(R) ₂ , SR, SOR, SO2R, S0 ₂ N(R) ₂ , SO3R, C(0)R, C(0)C(0)R, C(0)CH ₂ C(0)R, C(S)R, C(0)OR, OC(0)R, C(0)N(R) ₂ , OC(0)N(R) ₂ , C(S)N(R) ₂ , (CH ₂ )o- ₂ N(R)C(0)R, (CH ₂ )o- N(R)N(R) ₂ , N(R)N(R)C(0)R, N(R)N(R)C(0)OR, N(R)N(R)CON(R) ₂ , N(R)S0 ₂ R,

N(R)S0 ₂ N(R) ₂ , N(R)C(0)OR, N(R)C(0)R, N(R)C(S)R, N(R)C(0)N(R) ₂ , N(R)C(S)N(R) ₂ , N(COR)COR, N(()R)R, C(=NH)N(R) ₂ , C(0)N(OR)R, C(=NOR)R, and substituted or unsubstituted (Ci-Cioo)hydrocarbyl, wherein R can be hydrogen (in examples that include other carbon atoms) or a carbon-based moiety, and wherein the carbon-based moiety can be substituted or un sub stituted .

[0018] The term "substituted" as used herein in conjunction with a molecule or an organic group as defined herein refers to the state in which one or more hydrogen atoms contained therein are replaced by one or more non-hydrogen atoms. The term "functional group" or "substituent" as used herein refers to a group that can be or is substituted onto a molecule or onto an organic group. Examples of substituents or functional groups include, but are not limited to, a halogen (e.g., F, CI, Br, and I); an oxygen atom in groups such as hydroxy groups, alkoxy groups, aryloxy groups, aralkyloxy groups, oxo(carbonyl) groups, carboxyl groups including carboxylic acids, carboxylates, and carboxylate esters; a sulfur atom in groups such as thiol groups, alkyl and aryl sulfide groups, sulfoxide groups, sulfone groups, sulfonyl groups, and sulfonamide groups, a nitrogen atom in groups such as amines, hydroxyamines, nitriles, nitro groups, N-oxides, hydrazides, azides, and enamines; and other heteroatoms in various other groups. Non-limiting examples of substituents that can be bonded to a substituted carbon (or other) atom include F, CI, Br, I, OR, OC(0)N(R) ₂ , CN, NO, N0 ₂ , ON() ₂ , azido, CF ₃ , OCF3, R, O (oxo), S (thiono), C(O), S(O), methylenedioxy, ethylenedioxy, N(R) ₂ , SR, SOR, S0 ₂ R, S0 ₂ N(R) ₂ , SO3R, C(0)R, C(0)C(0)R, C(0)CH ₂ C(0)R, C(S)R, C(0)OR, OC(0)R, C(0)N(R) ₂ , OC(Q)N(R) ₂ , C(S)N(R) ₂ , (CH ₂ ) _G-2 N(R)C(0)R, (CH ₂ )o. ₂ N(R)N(R)2,

N(R)N(R)C(0)R, N(R)N(R)C(0)OR, N(R)N(R)CON(R) ₂ , N(R)S0 ₂ R, N(R)S0 ₂ N(R) ₂ ,

N(R)C(Q)OR, N(R)C(0)R, N(R)C(S)R, N(R)C(0)N(R) ₂ , N(R)C(S)N(R) ₂ , N(COR)COR, N(OR)R, C( Xl ! jXiRK C(0)N(OR)R, and C(=NOR)R, wherein R can be hydrogen or a carbon-based moiety; for example, R can be hydrogen, (Ci-Cioo)hydrocarbyl, alkyl, acyl, cycloalkyl, aryl, aralkyl, heterocyclyl, heteroaryl, or heteroarylalkyl; or wherein two R groups bonded to a nitrogen atom or to adjacent nitrogen atoms can together with the nitrogen atom or atoms form a heterocyclyl.

[0019] The term "alkyl" as used herein refers to straight chain and branched alkyl groups and cycloalkyl groups having from J to 40 carbon atoms, 1 to about 20 carbon atoms, 1 to 12 carbons or, in some embodiments, from 1 to 8 carbon atoms. Examples of straight chain alkyl groups include those with from 1 to 8 carbon atoms such as methyl, ethyl, n-propyl, n-butyl, n- pentyl, n-hexyl, n-heptyl, and n-octyl groups. Examples of branched alkyl groups include, but are not limited to, isopropyl, iso-butyl, sec-butyl, t-butyi, neopentyl, isopentyl, and 2,2- dimethylpropyl groups. As used herein, the term "alkyl" encompasses n-alkyl, isoalkyl, and anteisoaikyl groups as well as other branched chain forms of alkyl. Representative substituted alkyl groups can be substituted one or more times with any of the groups listed herein, for example, amino, hydroxy, cyano, carboxy, nitro, thio, alkoxy, and halogen groups.

[0020] The term "alkenyl" as used herein refers to straight and branched chain and cyclic alkyl groups as defined herein, except that at least one double bond exists between two carbon atoms. Thus, alkenyl groups have from 2 to 40 carbon atoms, or 2 to about 20 carbon atoms, or 2 to 12 carbon atoms or, in some embodiments, from 2 to 8 carbon atoms. Examples include, but are not limited to vinyl, -ΠίΊ ί C ^' l 1{C I ! 0. - C(CH ₂ CH ₃ )=CH ₂ , cyclohexenvl, cyclopentenvl, cyclohexadienyl, butadienyl, pentadienvl, and hexadienyl among others.

[0021] The term "acyl" as used herein refers to a group containing a carbonyl moiety wherein the group is bonded via the carbonyl carbon atom. The carbonyl carbon atom is bonded to a hydrogen forming a "formyl" group or is bonded to another carbon atom, which can be part of an alkyl, aryl, aralkyl cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, heteroaryi alkyl group or the like. An acyl group can include 0 to about 12, 0 to about 20, or 0 to about 40 additional carbon atoms bonded to the carbonyl group. An acyl group can include double or triple bonds within the meaning herein. An acryloyl group is an example of an acyl group. An acyl group can also include heteroatoms within the meaning herein. A nicotinoyl group (pyridyl-3-carbonyl) is an example of an acyl group within the meaning herein. Other examples include acetyl, benzoyl, phenvlacetvl, pyridyl acetyl, cinnamoyl, and acryloyl groups and the like. When the group containing the carbon atom that is bonded to the carbonyl carbon atom contains a halogen, the group is termed a "haloacyl" group. An example is a trifluoroacetyi group.

[0022] The term "aryi" as used herein refers to cyclic aromatic hydrocarbon groups that do not contain heteroatoms in the ring. Thus aryl groups include, but are not limited to, phenyl, azulenyl, heptalenyl, biphenyl, indacenyl, fluorenyl, phenanthrenyl, tri phenyl en yl, pyrenyl, naphthacenyi, chrysenyl, biphenylenyl, anthracenyl, and naphthyl groups. In some

embodiments, aryl groups contain about 6 to about 14 carbons in the ring portions of the groups, Aryl groups can be unsubstituted or substituted, as defined herein. Representative substituted aryl groups can be mono-substituted or substituted more than once, such as, but not limited to, a phenyl group substituted at any one or more of 2-, 3-, 4-, 5-, or 6-positions of the phenyl ring, or a naphthyl group substituted at any one or more of 2- to 8-positions thereof.

[0023] The term "heterocyclyl" as used herein refers to aromatic and non-aromatic ring compounds containing three or more ring members, of which one or more is a heteroatom such as, but not limited to, N, O, and S.

[0024] The term "heteroaryl" as used herein refers to aromatic ring compounds containing 5 or more ring members, of which, one or more is a heteroatom such as, but not limited to, N, O, and S; for instance, heteroaryl rings can have 5 to about 8-12 ring members. A heteroaryl group is a variety of a heterocyclyl group that possesses an aromatic electronic staicture. The term "heterocyclylalkyl" as used herein refers to alkyl groups as defined herein in which a hydrogen or carbon bond of an alkyl group as defined herein is replaced with a bond to a heterocyclyl group as defined herein. Representative heterocyclyl alkyl groups include, but are not limited to, furan-2-yl methyl, furan-3-yl methyl, pyridine-3-yl methyl, tetrahydrofuran-2-yl ethyl, and indol-2-yl propyl,

[0025] The term "alkoxy" as used herein refers to an oxygen atom connected to an alkyl group, including a cycloalkyl group, as are defined herein. Examples of linear alkoxy groups include but are not limited to methoxy, ethoxy, propoxy, butoxy, pentyloxy, hexyloxy, and the like. Examples of branched alkoxy include but are not limited to isopropoxy, sec-butoxy, tert- butoxy, isopentyloxy, isohexyloxy, and the like. Examples of cyclic alkoxy include but are not limited to cyclopropyloxy, cyclobutyloxy, cyclopentyloxy, cyclohexyloxy, and the like. An alkoxy group can include about 1 to about 12, about 1 to about 20, or about 1 to about 40 carbon atoms bonded to the oxygen atom, and can further include double or triple bonds, and can also include heteroatoms. For example, an ailyloxy group or a methoxyethoxy group is also an alkoxy group within the meaning herein, as is a methyl enedioxy group in a context where two adjacent atoms of a structure are substituted therewith.

[0026] The term "amine" as used herein refers to primary, secondary, and tertiary amines having, e.g., the formula N(group) ₃ wherein each group can independently be H or non-H, such as aikyi, aryl, and the like. Amines include but are not limited to R-NHi, for example,

alkylamines, aryl amines, alkylaryl amines; R ₂ NH wherein each R is independently selected, such as dialkylamines, diarylamines, araikyiamines, heterocyclylamines and the like; and R ₃ N

wherein each R is independently selected, such as trialkylamines, dialkylarylamines,

alkyldiarylamines, triarylamines, and the like. The term "amine ^' " also includes ammonium ions as used herein.

[0027j The terms "halo," "halogen," or "haiide" group, as used herein, by themselves or as part of another substituent, mean, unless otherwise stated, a fluorine, chlorine, bromine, or iodine atom.

[0028] The term "hydrocarbon" or "hydrocarbyi" as used herein refers to a molecule or functional group, respectively, that includes carbon and hydrogen atoms. The term can also refer to molecule or functional group that normally includes both carbon and hydrogen atoms but wherein all the hydrogen atoms are substituted with other functional groups,

[0029] As used herein, the term "hydrocarbyi" refers to a functional group derived from a straight chain, branched, or cyclic hydrocarbon, and can be aikyi, alkenyl, alkynyl, aryl, cycloal kyl , acyl, or any combination thereof. Hydrocarbyi groups can be shown as (C _a - Cb)hydrocarbyl, wherein a and b are integers and mean having any of a to b number of carbon atoms. For example, (C:i-C ₄ )hydrocarbyl means the hydrocarbyi group can be methyl (Ci), ethyl (C ₂ ), propyl (C ₃ ), or butyl (C ₄ ), and (Co-Cb)hydrocarbyl means in certain embodiments there is no hydrocarbyi group.

[00301 The term "number-average molecular weight" (M _a ) as used herein refers to the ordinary arithmetic mean of the molecular weight of individual molecules in a sample. It is defined as the total weight of all molecules in a sample divided by the total number of molecules in the sample. Experimentally, M _n is determined by analyzing a sample divided into molecular weight fractions of species i having m molecules of molecular weight Mi through the formula M _n = ΣΜ.ηί /∑n.. The M _n can be measured by a variety of well-known methods including gel permeation chromatography, spectroscopic end group analysis, and osmometry. If unspecified, molecular weights of polymers given herein are number-average molecular weights.

[0031] The term "solvent" as used herein refers to a liquid that can dissolve a solid, liquid, or gas. Non-limiting examples of solvents are silicones, organic compounds, water, alcohols, ionic liquids, and supercritical fluids.

[0032] The term "air" as used herein refers to a mixture of gases with a composition approximately identical to the native composition of gases taken from the atmosphere, generally at ground level. In some examples, air is taken from the ambient surroundings. Air has a composition that includes approximately 78% nitrogen, 21% oxygen, 1% argon, and 0.04% carbon dioxide, as well as small amounts of other gases.

[0033] The term "room temperature" as used herein refers to a temperature of about 15

°C to 28 °C.

[0034] The term "standard temperature and pressure" as used herein refers to 20 ^C 'C and

101 kPa.

[0035] The term "coating" as used herein refers to a continuous or discontinuous layer of material on the coated surface, wherein the layer of material can penetrate the surface and can fill areas such as pores, wherein the layer of material can have any three-dimensional shape, including a fiat or curved plane. In one example, a coating can be formed on one or more surfaces, any of which may be porous or nonporous, by immersion in a bath of coating material.

[0036] The term "surface" as used herein refers to a boundary or side of an object, wherein the boundary or side can have any perimeter shape and can have any three-dimensional shape, including flat, curved, or angular, wherein the boundary or side can be continuous or discontinuous. While the term surface generally refers to the outermost boundary of an object with no implied depth, when the term 'pores' is used in reference to a surface, it refers to both the surface opening and the depth to which the pores extend beneath the surface into the

substrate.

[0037] As used herein, the term "polymer" refers to a molecule having at least one repeating unit and can include copolymers.

[0038] In various embodiments, salts having a positively charged counterion can include any suitable positively charged counterion. For example, the counterion can be

ammonium(NH ₄ ^~ ), or an alkali metal such as sodium (Na ^"f ), potassium (EC), or lithium (Li ⁺ ). In some embodiments, the countenon can have a positive charge greater than +1, which can in some embodiments complex to multiple ionized groups, such as Zn ²⁺ , Al ³⁺ , or alkaline earth metals such as Ca ^1÷ or Mg ^2÷ .

[0039] In various embodiments, salts having a negatively charged counterion can include any suitable negatively charged counterion . For example, the counterion can be a halide, such as fluoride, chloride, iodide, or bromide. In other examples, the counterion can be nitrate, hydrogen sulfate, dihydrogen phosphate, bicarbonate, nitrite, perchlorate, iodate, chlorate, bromate, chlorite, hypochlorite, hypobromite, cyanide, amide, cyanate, hydroxide, permanganate. The counterion can be a conjugate base of any carboxylic acid, such as acetate or formate. In some embodiments, a counterion can have a negative charge greater than -1 , which can in some embodiments complex to multiple ionized groups, such as oxide, sulfide, nitride, arsenate, phosphate, arsenite, hydrogen phosphate, sulfate, thiosulfate, sulfite, carbonate, chromate, dichromate, peroxide, or oxalate.

[0040] The polymers described herein can terminate in any suitable way. In some embodiments, the polymers can terminate with an end group that is independently chosen from a suitable polymerization initiator, -H, -OH, a substituted or unsubstituted (Ci-C?o)hydrocarbyl (e.g., (Ci-Cio)alkyl or (C6-C ₂₀ )aryl) interrupted with 0, 1 , 2, or 3 groups independently selected from -0-, substituted or unsubstituted -NH-, and -S-, a poly(substituted or unsubstituted (Ci- C ₂₀ )hydrocarbyloxy), and a poly(substituted or unsubstituted (C ₁ -C ₂₀ )hydrocarbylamino).

Method of melt-stabilizing ultra high molecular weight, polyethylene (UHMWPE).

[0041] Oxidation of polyethylene can occur through a free radical pathway, as shown in the following sequence:

RH + IN --→ R- Initiation

R- + 0 ₂ → ROO-

ROO + RH→ ROOH + R- Propagation

ROOH ---> RO- + HQ-

RO- + RH→ ROH + R- Chain Branching

HO- + RH→ HOH + R- ROO- (RO- etc.)→ Inert Products Termination

ROO- + AH→ ROOH + A- RO + AH→ ROH + A- Inhibition (stabilization)

HO + AH ---> HOH + A- wherein

RH = ^:: polymer (e.g., polyethylene, UHMWPE)

IN = initiator (e.g., irradiation)

AH = inhibitor (e.g., free-radical scavenging antioxidant)

[0042] In various embodiments, the present invention provides a method of melt- stabilizing ultra high molecular weight polyethylene (UHMWPE). The method can include coating a solid material including UHMWPE with an antioxidant, to provide an antioxidant- coated solid material. The method can include pre-irradiatively heating the antioxidant-coated solid material to diffuse the antioxidant therein, to provide an antioxidant-diffused solid material. The method can include irradiating the antioxidant-diffused solid material, to provide an irradiated solid material. The method can include post-irradiatively heating the irradiated solid material, the heating sufficient to melt at least part of the UHMWPE, to provide a heated material. The method can include solidifying the heated material, to provide a melt-stabilized material.

[0043] In certain examples, one or more agents, e.g., bioactive agents, can be added to the material including UHMWPE. Such addition can be accomplished during any stage of preparation but may be desirable after any heat treatments are performed to reduce the likelihood of deactivation of the bioactive agent. Illustrative agents include, but are not limited to, an antibiotic, a steroid, a drug, a growth factor such as bone morphogenic protein, an osteocyte, an osteoclast or other cells, a vitamin, a chondroitin, a glucosamine, a glycosoaminglycan, high energy phosphates such as phosphoenolpyruvate, ATP, 5 '-AMP, and other small molecule biologies or other chemical or biological agents. In some examples, the material including UHMWPE can be loaded with stem cells, and the material can act as a scaffold to permit growth and differentiation of bone or cartilage within the polymer framework. The presence of an antioxidant in the material including UHMWPE can act to prevent degradation of the scaffold in its use environment and may also provide some oxidative protection to the bioactive agent or stem cells loaded into the scaffold.

[0044] In certain examples, the method of melt-stabilizing UHMWPE can include any suitable physical manipulation before, between, or after any suitable steps of the method (e.g., coating, pre-irradiatively heating, preheating, irradiating, post-irradiativeiy heating, or solidifying), such as molding, compressing, consolidating, removing material from, or otherwise processing to provide a desired shape, part size, or other physical attributes to render the part suitable for its intended use.

[0045] In certain embodiments, additional components may be combined with the material including UHMWPE before, between, or after any suitable steps of the method (e.g., any of coating, pre-irradiatively heating, preheating, irradiating, post-irradiatively heating, or solidifying). In one embodiment, triboiogical components such as metal and/or ceramic articulating components and/or preassembled bipolar components may be joined with the material including UHMWPE. In other embodiments, metal backing (e.g., plates or shields) may be added. In further embodiments, surface components such a trabecular metal, fiber metal, Sulmesh ^1M coating, meshes, cancellous titanium, and/or metal or polymer coatings may be added to or j oined with the material including UHMWPE. Radiomarkers or radiopacifiers such as tantalum, steel and/or titanium balls, wires, bolts or pegs may be added. Locking features such as rings, bolts, pegs, snaps and/or cements/adhesives can be added. These additional

components may be used to form sandwich implant designs, radiomarked implants, metal- backed implants to prevent direct bone contact, functional growth surfaces, and/or implants with locking features, Material including UHMWPE.

[0046] The material including the UHMWPE is a solid monolithic material, such as a single solid mass, a non-particuiate form, a non-powder, a bar, or a form. Any suitable proportion of the solid material including UHMWPE can be the UHMWPE, such as about 1 wt% to about 100 wt% of the solid material, about 90 wt% to about 100 wt%, or about 1 wt% or less, or about 2, 3, 4, 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, 95, 96, 97, 98, 99, or about 99.9 wt% or more. The UHMWPE can form a homogeneous or heterogeneous mixture with other components in the solid material.

[0047] UHWMPE is a semi crystalline, linear homopolymer of ethylene, which in some embodiments can be produced by stereospecific polymerization with a Ziegler-Natta catalyst at low pressure (6-8 bar) and low temperature (66-80°C). The synthesis of UHMWPE can result in a fine granular powder. The molecular weight and its distribution can be controlled by process parameters such as temperature, time and pressure. UHMWPE generally has a molecular weight of at least about 2,000,000 g mol. Suitable UHMWPE materials for use as raw materials may be in the form of a powder or mixture of powders. Examples of suitable UHMWPE materials include GUR® 1020 and GUR® 1050 available from Ticona Engineering Polymers. UHMWPE powder can be processed and consolidated to form a solid monolithic material ,

[0048] In addition to UHMWPE, the solid material including UHMWPE can include any other suitable component, in certain embodiments, the UHWMPE can be combined with another crosslinkable polymer. The crossiinkable polymer can be any polymer that is crosslinkable using radiation, a chemical crosslinking agent or that can be physically cross- linked under suitable conditions. In some examples, the polymer can be a thermoplastic polymer such as, for example, an acrylonitrile butadiene styrene (ABS) polymer, an acrylic polymer, a celluloid polymer, a cellulose acetate polymer, a eycloolefin copolymer (COC), an ethylene- vinyl acetate (EVA) polymer, an ethylene vinyl alcohol (EVOH) polymer, a fluoroplastic, an ionomer, an acrylic/PVC alloy, a liquid crystal polymer (LCP), a polyacetal polymer (POM or acetal), a polyacrylate polymer, a polyacrylonitriie polymer (PAN or acrylonitrile), a polyamide polymer (PA or nylon), a polyamide-imide polymer (PAI), a polyaryletherketone polymer (PAEK or ketone), a polybutadiene polymer (PBD), a polybutylene polymer (PB), a

polybutylene terephthalate polymer (PBT), a polycaprolactone polymer (PCL), a

polychiorotrifluoroethylene polymer (PCTFE), a polyethylene terephthalate polymer (PET), a polycyclohexylene dimethylene terephthalate polymer (PCT), a polycarbonate polymer, a polyhydroxyalkanoate polymer (PHA), a polyketone polymer (PK), a polyester polymer, a polyethylene polymer (PE), a polyetheretherketone polymer (PEEK), a polyetherketoneketone polymer (PEKK), a polyetherimide polymer (PEI), a polyethersulfone polymer (PES), a polyethylenechlorinate polymer (PEC), a poiyimide polymer (PI), a poiylactic acid polymer (PLA), a polymethylpentene polymer (PMP), a polyphenylene oxide polymer (PPO), a polyphenylene sulfide polymer (PPS), a polyphthalamide polymer (PPA), a polypropylene polymer, a polystyrene polymer (PS), a polysulfone polymer (PSU), a polytrimethylene terephthalate polymer (PTT), a polyurethane polymer (PIT), a polyvinyl acetate polymer (PVA), a polyvinyl chloride polymer (PVC), a polyvinylidene chloride polymer (PVDC), and a styrene- acrylonitrile polymer (SAN), illustrative types of polyethylene in addition to the UHMWPE include, for example, ultra low molecular weight polyethylene (ULMWPE), high molecular weight polyethylene (HMWPE), high density polyethylene (HDPE), high density cross-linked polyethylene (HDXLPE), cross-linked polyethylene (PEX or XLPE), medium density polyethylene (MDPE), low density polyethylene (LDPE), linear low density polyethylene (LLDPE) and very low density polyethylene (VLDPE). In some examples, a polypropylene can be used. A polypropylene may be particularly desirable where the final product is a mesh, stent, breast implant material, suture material or other medical device. In one alternative, a polypropylene (or other polymer) may be used as one layer in a multi-layered medical device. Illustrative polypropylenes include, but are not limited to, a homopolymeric polypropylene, a block copolymeric polypropylene, and a random copolymeric polypropylene. In certain examples, the polymers used in the compositions described herein can be copolymerized with one or more monomers or polymers. The solid material including UHMWPE can be a consolidated mixture of UHMWPE and any other suitable component.

[0049] In certain examples, the solid material including UHMWPE can include one or more suitable additives that impart a desired physical or chemical property. Illustrative suitable additives include, but are not limited to, radiopaque materials, antimicrobial materials such as silver ions, antibiotics, and microparticles and/or nanoparticles serving various functions.

Preservatives, colorants and other conventional additives may also be used.

[0050] In certain embodiments, the solid material including UHMWPE can be prepared by a method including blending aUHMWPE powder with other suitable materials, such as a blend with another polymer or a blend with an antioxidant. Such processes include physical mixing, mixing with the aid of a solvent, mixing with the aid of a solvent (e.g., C0 ₂ ) under supercritical temperature and pressure conditions, and ultrasonic mixing.

[0051] In some embodiments, the solid material including UHMWPE can include an antioxidant, such as any one or more suitable antioxidants described herein. The one or more antioxidants can be present in any suitable concentration, such as any concentration described herein. The one or more antioxidant can be present in any type of distribution in the solid material including UHMWPE, such as a substantially homogeneous distribution. In other embodiments, the solid material including UHMWPE can be substantially free of antioxidants. Coating. [0052] The method includes coating the solid material including UHMWPE with an antioxidant, to provide an antioxidant-coated solid material. The antioxidant can be applied neat or as part of a liquid composition including the antioxidant. The coating can be any suitable coating method that applies the antioxidant sufficiently such that the antioxidant can penetrate a surface layer of the solid material including UHMWPE. The coating can be performed using any suitable coating process, such as one or more of brushing, dipping, soaking, immersion with agitation or stirring, spraying, and the like.

[0053] The coating can be sufficient for the antioxidant to infuse (e.g., penetrate) into a surface layer of the solid material including UHMWPE that includes any suitable depth from the surface of the solid material including UHMWPE where the coating is applied, such as about 0 mm (e.g., only present on or very near the surface of application), about 0 mm to about 1 mm, about 0 mm to about 10 mm deep, about 1 mm to about 10 mm deep, about 0 mm to about 20 mm deep, about 1 mm or less, or about 1.5 mm, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 6.5, 7, 7.5, 8, 8.5, 9, 9.5, 10, 1 1 , 12, 13, 14, 15, 16, 17, 18, 19, or about 20 mm or more. In various embodiments, the coating can be performed such that the antioxidant does not penetrate past a certain depth of the solid material including UHMWPE. For example, in some embodiments, the coating penetrates the solid material including UHMWPE no deeper than about 1 mm or less, or about 1.5 mm, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5,5, 6, 6.5, 7, 7.5, 8, 8.5, 9, 9.5, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 mm, or about 20 mm or more. In some embodiments, the coating does not penetrate past the surface layer, wherein the non-surface layer portions of the solid material including UHMWPE are substantially free of the antioxidant. In various embodiments, the coating penetrates the solid material including UHMWPE such that in at least one of the antioxidant-coated solid material the antioxidant is present to a depth of about 0 mm to about 1 mm, about 0 mm to about 10 mm deep, about 1 mm to about 10 mm deep, about 0 mm to about 20 mm deep, about 1 mm or less, or about 1.5 mm, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 6,5, 7, 7,5, 8, 8.5, 9, 9.5, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, or about 20 mm or more. Subsequent to penetration, the antioxidant can diffuse through the UHMWPE material, such as during pre-irradiative heating.

[0054] In some embodiments, the antioxidant added via the coating can protect the

UHMWPE in the solid material including UHMWPE from oxidation by oxygen in the air during a subsequent melt-stabilization. For example, the coating can allow the antioxidant to penetrate and subsequently diffuse into the UHMWPE on the surface of the solid material including UHMWPE and protect the UHMWPE therein from oxidation by oxygen in the air, as described herein,

[0055] The coating can include coating any suitable proportion of the total surface area of the solid material including UHMWPE. The coating can include selective coating or uniform coating of the solid material including UHMWPE. The coating can be sufficient to contact the antioxidant with at least some of the UHMWPE in the solid material including UHMWPE, wherein the UHMWPE can be on the surface or proximate to the surface (e.g., within 1 mm to about 10 mm), hi an embodiment wherein the solid material only has exposed UHMWPE on a portion of the surface, or only has UHMWPE within about 1-10 mm of only a portion of the surface, the method can optionally include only coating the part of the surface of the solid material that includes the UHMWPE or that is proximate to UHMWPE. For example, the coating can include coating about 1% to about 100% of the total surface area of the solid material, about 50% to about 100%, about 90% to about 100%, or about 1% or less, or about 2%, 3, 4, 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 99.5, 99.9, 99.99, or about 99.999% or more.

[0056] The coating can be sufficient to provide any suitable weight gain to the solid material including UHMWPE, such that the antioxidant is suitably applied to the solid material including UHMWPE. For example, the coating can be sufficient to provide a weight gain of about 0.000,01 g per cm ² surface area of the solid material to about 50 g/cm ² surface area, about 0.000,1 g/cm ² surface area to about 1 g cm ² surface area, about 0.000,01 g/cm ² surface area or less, or about 0.000, 1 g/cm ² surface area, 0.000,2, 0.000,5, 0.000,8, 0.001 , 0.005, 0.01 , 0.05, 0, 1 , 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 6, 7, 8, 9, 10, 12, 14, 16, 18, 20, 25, 30, 35, 40, 45, or about 50 g/cm ² surface area or more. Liquid composition including the antioxidant.

[0057] The coating of the solid material including UHMWPE with an antioxidant can include coating the solid material with neat antioxidant or coating the solid material with a liquid composition including the antioxidant. The liquid composition can be a solution of the one or more antioxidants in one or more suitable solvents (e.g., carrier liquids). The neat antioxidant can be applied if it is a liquid with low enough viscosity, or it can be dissolved in a suitable carrier fluid, such as if it is a viscous liquid or solid. The concentration of the antioxidant can be varied to control the amount of antioxidant infused and diffused in the solid material including UHMWPE. The antioxidant or the multiple antioxidants can be any suitable wt% of the liquid composition, such as about 0.01 wt% to about 100 wt% of the liquid composition, about 1 wt% to about 100 wt%, about 5 wt% to about 100 wt%, about 0.01 wt% or less, or about 0.1 wt%, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, 91 , 92, 93, 94, 95, 96, 97, 98, 99, 99.5, 99.9, 99.99, or about 99.999 wt% of the liquid composition or more.

[0058] The carrier liquid can be any suitable carrier liquid. The carrier liquid can be water (e.g., di-ionized water), or an aqueous solution (e.g., saline). The carrier liquid can be an organic solvent, such as any suitable organic solvent, such as acetone, methanol, ethanol, or propanol (e.g., isopropanol or normal propanol). The carrier liquid can be any suitable proportion of the liquid composition including the antioxidant, such as about I wt% to about 99 wt%, 5 wt% to about 95 wt%, or about 1 wt% or less, or about 2 wt%, 3, 4, 5, 0, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, 91, 92, 93, 94, 95, 96, 97, 98, or about 99 wt% or more. In embodiments of the method wherein the liquid composition includes one or more solvents, the method can include heating the material including UHMWPE in subsequent steps sufficiently such that one or more of the one or more solvents is substantially completely evaporated from the material including UHMWPE, for example, such that only the one or more antioxidants are left behind.

[0059] The liquid composition can include any suitable material in addition to the one or more antioxidants and the one or more optional carrier fluids. For example, in some

embodiments, the liquid composition includes one or more organic peroxides. In some embodiments, the one or more organic peroxides can provide crosslinking, reducing or eliminating a subsequent irradiation crosslinking step. Antioxidant.

[0060] The antioxidant can be any suitable antioxidant. The antioxidant can be a free- radical scavenger, such that the antioxidant can neutralize a tree-radical before the free-radical can react with oxygen to form an oxidized species. The antioxidant can be any suitable antioxidant that allows the method to effectively produce materials including UHMWPE that can resist oxidation, such as melt-stabilized materials including UHMWPE having less or no oxidized layer when melt-stabilized in an oxygen-containing environment. One antioxidant can be used, or multiple antioxidants can be used.

[0061] The one or more antioxidants can form any suitable wt% of the material including the UHMWPE, such as the antioxidant-coated solid material, the antioxidant-diffused solid material, the irradiated solid material, the heated material, or the melt-stabilized material, such as about 0.01 wt% to about 20 wt%, about 0.1 wt% to about 5 wt%, about 0.01 \vt% or less, or about 0,05 wt%, 0.1 , 0,2, 0,3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1 , 1 .2, 1 .4, 1 .6, 1 .8, 2, 2,2, 2,4, 2.6, 2.8, 3, 3.5, 4, 4.5, 5, 6, 7, 8, 9, 10, 15, or about 20 wt% or more.

[0062] The antioxidant can have a molecular weight that allows the antioxidant to diffuse effectively during the pre-irradiative heating. For example, the antioxidant can have a molecular weight of less than 10,000 g/mol, or less than 5,000, about 100 to about 5,000, about 100 to about 2,000, about 100 or less, or about 200, 300, 400, 500, 600, 700, 800, 900, 1,000, 1,200, 1,400, 1,600, 1,800, 2,000, 2,500, 3,000, 3,500, 4,000, 4,500, 5,000, 6,000, 7,000, 8,000, 9,000, or about 10,000 g/mol or more.

[0063] The antioxidant can be at least one of a tocopherol, a tocopherol phosphite, a tocotrienol, vitamin E, vitamin E acetate, a protected vitamin E, a rosemary oil, pentaerythritol tetrakis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate), butanedioic acid dimethyl ester/4- hydroxy-2,2,6,6-tetramethyl-l -piped dine ethanol copolymer, tannic acid, bilberry extract, vitamin C, a carotene, a flavonoid, an isoflavonoid, a neoflavonoid, a lignin, quinine, ubiquinone, vitamin Kl, a metal, glutathione, propyl gallate, octyl gallate, lauryl gallate, resveratrol, rosmarinic acid, rutin, 5-aminosalicylic acid, butylated hydroxy anisole, butylated hydroxy toluene, a phenolic compound, and a monomelic or polymeric hindered amine stabilizer. The antioxidant can be at least one of vitamin E, vitamin E acetate, pentaerythritol tetrakis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate), butanedioic acid dimethyl ester/4- hydroxy-2,2,6,6-tetramethyl- 1 -piperidine ethanol copolymer, tannic acid, and bilberry extract. The antioxidant can be at least one of racemic alpha-tocopherol, RRR-alpha-toeopherol, SRR- alpha-tocopherol, SSR-alpha-tocopherol, SRS-alpha-tocopherol, SSS-alpha-tocopherol, RSR- alpha-tocopherol, RRS-alpha-tocopheroi, RSS-alpha-tocopherol, racemic beta-tocopherol, RRR- beta-tocopheroi, SRR-beta-tocopherol, SSR-beta-tocopherol, SRS-beta-tocopherol, SSS-beta- tocopherol, RSR-beta-tocopherol, RRS-beta-tocopherol, RSS-beta-tocopherol, racemic gamma- tocopheroi, RRR-gamma-tocopherol, SRR-gamma-tocopherol, SSR-gamma-tocopherol, SRS- gamma-tocopherol, SSS-gamma-tocopherol, RSR-gamma-tocopherol, RRS-gamma-tocopherol, RSS-gamma-tocopherol, racemic delta-tocopherol, RRR-delta-tocopherol, SRR-delta- tocopherol, SSR-delta-tocopherol, SRS-delta-tocopherol, SSS-delta-tocopherol, RSR-delta- tocopherol, RRS-delta-tocopherol, and RSS-delta-tocopherol.

[0064 A tocopherol can have the structure:

The variables R ^1A , R ^2A , and R ^3A are each independently selected from hydrogen, substituted or ui substituted (Ci-Cio)alkyl, and substituted or unsubstituted (d-Cic alkenyl . The

stereochemistry of the tocopherol can be racemic or at least one of RRR, SRR, SSR, SRS, RSR, RRS, RSS, and SSS. in some embodiments, R ^{i A} , R ^2A , and R ^3A are each (Ci-Cio)alkyi, such as methyl (e.g., alpha- tocopherol). In some embodiments, R ^1A and R ^A are each (Ci-Cio)alkyl, such as methyl, and R ^2A is hydrogen (beta-tocopherol). In some embodiments, R ^2A and R ^3A are each (Ci-Cio)alkyi, such as methyl, and R ^lA is hydrogen (gamma-tocopherol). In some embodiments, R ^iA and R ^2A are each h drogen and R ^jA is (Ci-Cio)alkyl, such as methyl (deita-tocopherol).

The variables R ^1B , R ^2B , and R ^3B are each independently selected from hydrogen, substituted or unsubstituted (Ci-Cio)alkyl, and substituted or unsubstituted (Ci-C!o)alkenyl . The

stereochemistry of the tocotrienol can be racemic or at least one of R and S. In some

embodiments, R ^1B , R ^2B , and R ^3B are each (Ci-C ₁₀ )alkyl, such as methyl (e.g., alpha-tocotrienol). In some embodiments, R ^lB and R ^3B are each (Ci-Cio)alkyl, such as methyl, and R ^2B is hydrogen (beta-tocotrienol). In some embodiments, R ^2B and R ^3B are each (Ci-CioMkyl, such as methyl, and R ^lB is hydrogen (gamma-tocotrienol). In some embodiments, R ^!b and R ^2B are each hydrogen and R ^JB is (Ci-Ciojalkyl, such as methyl (delta-tocotri enol) . A tocopherol or tocotrienol can be naturally occurring or synthetic.

[0066] In various embodiments, the antioxidant can be at least one of a hindered amine stabilizer or a hindered phenol stabilizer. For example, the antioxidant can be at least one of 4- Allyloxy-2-hydroxybenzophenone, l-aza-3,7-dioxabicyclo[3.3.0]octane-5-methanol, 2-(2H- benzotriazol-2-yl)-4,6-bis( 1 -methyl- 1 -phenyl ethyl )phenol, 2-(2H-benzotriazol-2-yl)-4,6-di-tert- pentylphenol, 2-(2H-benzotriazol-2-yl)-6-dodecyl-4-methylphenol, 2-[3-(2H-benzotriazol-2-yl)- 4-hydroxyphenyl] ethyl methacrylate, 2-(2H-benzotriazol-2-yl)-4-methyl-6-(2-propenyl)phenol, 2-(2H-benzotriazol-2-yl)-4-(l,l ,3,3-tetramethylbutyl)phenol, 2-(4-benzoyl-3- hydroxyphenoxy)ethyl acrylate, 3,9-bis(2,4-dicumylphenoxy)-2,4,8,10-tetraoxa-3,9- diphosphaspiro[5.5]undecane, bis(octadecyl)hydroxylamine, 3,9-bis(octadecyloxy)-2,4,8,10- tetraoxa-3,9-diphosphaspiro[5.5]undecane, bis(l-octyloxy-2,2,6,6-tetramethyl-4-piperidyl) sebacate, bis(2,2,6,6-tetramethyl-4-piperidyl) sebacate, 2-tert-butyl-6-(5-chloro-2H-benzotriazol- 2-yl)-4-methylphenol, 2-tert-butyl-4-ethylphenol, 5-chloro-2-hydroxybenzophenone, 5-chloro-2- hydroxy-4-methylbenzophenone, 2,4-di-tert~butyl-6-(5-chloro-2H-benzotriazoI-2-yI)phenol, 2,6- di-tert-butyl-4-(dimethylaminomethyl)phenol, 3',5'-dichloro-2'-hydroxyacetophenone, didodecyl 3,3 '-thiodipropionate, 2,4-dihydroxybenzophenone, 2,2'-dihydroxy-4,4'- dimethoxybenzophenone, 2,2 '-di hydroxy-4-methoxybenzophenone, 2',4'-dihydroxy-3 '- propyl a cetophenone, 2,3-dimethylhydroquinone, 2-(4,6-diphenyl-l,3,5-triazin-2-yl)-5- [(hexyl)oxyj-phenol, 5-ethyl-I -aza-3,7-dioxabicyclo[3.3.0]octane, ethyl 2-cyano-3,3- diphenyl acrylate, 2-ethylhexyl 2-cyano-3, 3 -diphenyl acrylate, 2-ethylhexyl trans-4- methoxycinnamate, 2-ethylhexyl salicylate, 2,2'-ethylidene-bis(4,6-di-tert-butylphenol), 2- hydroxy-4-(octyloxy)benzophenone, menthyl anthranilate, 2-methoxyhydroquinone, methyl-p- benzoquinone, 2,2 '-methyl enebis[6-(2H-benzotriazol-2-yl)-4-(l,l,3,3-tetramethylbutyl) phenol], 2,2'-methylenebis(6-tert-butyl-4-ethylphenol), 2,2'-methylenebis(6-tert-butyl-4-methylphenol), 5,5 '-methyl enebis(2-hydroxy-4-methoxybenzophenone), methylhydroquinone, 4-nitrophenol sodium salt hydrate, octadecyi 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate, pentaerythritol tetrakis(3,5-di-tert-butyl-4-hydroxyhydrocinnamate), 2-phenyl-5-benzimidazolesulfonic acid, poly[[6-[(l , l,3,3-tetramethylbutyl)amino]-s-triazine-2,4-diyl]-[(2,2,6,6 -tetramethyl-4- piperidyl)imino]-hexamethylene-[(2,2,6,6-tetramethyl-4-piper idyl)irnino], sodium D~ isoascorbate monohydrate, tetrachloro-l,4-benzoquinone, triisodecyl phosphite, 1,3,5-trimethyl- 2,4,6-tris(3,5-di-tert-butyl-4-hydroxybenzyl)benzene, tris(4-tert-butyl-3-hydroxy-2,6- dimethylbenzyl) isocyanurate, tris(2,4-di-tert-butylphenyl) phosphite, l ,3,5~tris(2- hydroxyethyi)isocyanurate, and 2-[(2E,6E, 10E, 14E, 18E,22E,26E,30E,34E)- 3,7, 1 1, 1 5, 19,23,27,3 l,35,39-decamethyltetraconta-2,6, l 0, 14, 18,22,26,30,34,38-decaenyl]-5,6- dimethoxy-3-methyl-benzene-l,4-diol (e.g., Ubiquinol). In some embodiments, the hindered amine stabilizer is at least one of a 2,2,6,6-tetra((C ₁ -C5 ₀ )hydrocarbyl)-4-piperidyl diester of HOC(0)-(Ci-C5o)hydrocarbyl-C(0)OH, a 2,2,6,6-tetramethyl-4-piperidyl diester of HOC(O)- (C ₁ -C5 ₀ )hydrocarbyl-C(O)OH, bis(2,2,6,6-tetramethyl-4-piperidyl) sebacate, l ,2,2,6,6-penta((Ci- C ₅ o)hydrocar yl)-4-piperidyl diester of HOC(0)-(Ci-C ₅ o)hydrocai yl-C(0)OH, a 1,2,2,6,6- pentamethyl-4-piperidyl diester of HOC(0)-(C ₁ -C5o)hydrocarbyl-C(0)OH, 2,2,6,6- tetramethyipiperidine, wherein each (Ci-Cso)hydrocarbyl is independently selected, is substituted or unsubstituted, and is interrupted by 0, 1, 2, or 3 -O- groups.

[0067] The antioxidant can be a protected antioxidant. A protected antioxidant can be advantageous because it can avoid or reduce acting as an antioxidant during irradiative crosslinking, but after irradiative crosslinking (and deprotection) can act as an antioxidant to reduce oxidation and corresponding degradation of the UHMWPE. By avoiding or reducing antioxidant activity during crosslinking, a higher crosslinking density can be achieved.

[0068] In some embodiments, the antioxidant is a protected tocopherol or tocotrienol having the structure: r a salt thereof, or

OR ^a , or a salt thereof.

At each occurrence, R ^a can be independently chosen from -H, ~E, and substituted or

unsubstituted (Ci-Cio)hydroearbyl. The variable E can have the structure:

The variables R ^? , R ^s , and R ⁹ are each independently chosen from -H, substituted or unsubstituted (Ci-Cio)alkyi, and substituted or unsubstituted (Ci-Cio)aikenyl. The method can include converting at least some of protected tocopherol or tocotrienol to a compound of the formula E- OH, such as after the irradiative crosslinking.

[0069] The antioxidant can be a hindered amine stabilizer-protected tocopherol or tocotrienol of formula (I):

(I)

or a salt thereof The variables R ¹ , R ² , R ³ , and R ⁴ can be each, independently, hydrogen or Cio)alkyl. The variable R ⁵ can be chosen from hydrogen, (Ci-Cio)alkyi, -0% and -OR ¹¹ wherein R ¹¹ can be hydrogen or (Ci-Cio)alkyl . The variable E can have the structure:

The variables R ^? , R ^s , and R ⁹ can be each independently chosen from -H, substituted or unsubstituted (Ci-Cio)alkyl, and substituted or unsubstituted (Ci-Cio)alkenyl. The variable Y can represent the group:

ariable R can be hydrogen, (Ci-C!o) f the formula;

The one or more compounds of the formula (I) can be substantially uniformly distributed throughout the ultrahigh molecular weight polyethylene. The method include converting at least some of the compound of the formula (I) to a compound of the formula E-OH, after the irradiating step,

[0070] The group E-O- can be a vitamin E radical. The group R ⁶ -Q- can be a vitamin E radical. The variable R ⁶ can be a radical of the formula:

[0071] The variables R ^! , R , R ³ , R ⁴ , and I can be each, independently, (Ci-Cio)alkyl.

The variables R ¹ , R ² , R ³ , R ⁴ , and R ³ can be each methyl. The variable Y can represent the group:

R ⁶

O"

YV

Pre-irradiatively heating.

[0072] The method can include pre-irradiatively heating the antioxidant-coated solid material. The pre-irradiative heating diffuses the antioxidant in the solid material. The pre- irradiative heating provides an antioxidant-diffused solid material. The pre-i radiati e heating can be sufficient to at least partially diffuse the one or more antioxidants in the antioxidant- coated solid materi al. The pre-irradiative heating can dri ve the anti oxidant into the interi or of the material. The distance of the diffusion can be dependent on characteristics of the specific antioxidant such as molecular weight and similarity of solubility parameter with respect to UHMWPE, Migration distance and rate can also depend on the physical state of the antioxidant; for example, the diffusion distance can be greater when the melting point of the antioxidant is below the temperature achieved during the pre-irradiative heating.

[0073] The pre-irradiative heating can melt any suitable amount of the antioxidant- diffused solid material, or of the UHMWPE in the antioxidant-diffused solid m ateri al, such as about 0 vol% to about 100 vof%, or about 1 vol% or less, or about 2 vol%, 3, 4, 5, 6, 7, 8, 9, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, 95, 96, 97, 98, or about 99 vol% or more. The heating is sufficient to at least partially diffuse the one or more antioxidants in the antioxidant-coated solid material.

[0074] The method can include pre-irradiatively heating the antioxidant-diffused solid material in an environment including oxygen, the heating sufficient to melt at least part of the UHMWPE, to provide a heated material. In some embodiments, the method includes heating the antioxidant-diffused solid material in an environment substantially free of oxygen. Various embodiments of the present invention provide a means to reduce the oxidized layer that forms during pre-irradiative heating of a material including UHMWPE in an oxygen-containing environment such as air. During the pre-irradiative heating, the antioxidant can scavenge the free radicals present in the outer layer that would normally be oxidized. The pre-irradiative heating can occur in an environment including any suitable amount of oxygen. For example, the heating can occur in an environment including ambient air, having about 20-21 vol% oxygen. The heating can occur in an environment having about 1 voi% to about 50 vol% oxygen, about 10 vol% to about 30 vol% oxygen, about 1 vol% oxygen or less, or about 2 vol%, 3, 4, 5, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 46, 48, or about 50 vol% oxygen or more.

[0075] The pre-irradiative heating heats the antioxidant-diffused solid material to any suitable temperature, such as about 50 °C to about 300 °C, about 80 °C to about 250 °C, about 130 °C to about 160 °C, about 50 °C or less, or about 60 °C, 70, 80, 90, 100, 110, 120, 130, 140, 150, 160, 170, 180, 190, 200, 220, 240, 260, 280, or about 300 °C or more. The temperature achieved can be a temperature below the melting point (e.g., about 138 °C), or above the melting point. The antioxidant-diffused solid material can be heated for any suitable duration, such as about 1 minute to about 7 days, or about 1 hour to about 48 hours, or about 1 minute or less, or about 2 minutes, 3, 4, 5, 10, 1 5, 20, 25, 30, 35, 40, 45, 50, 55 minutes, 1 hour, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23 hours, 1 day, 1.5, 2, 2,5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 6.5 days, or about 7 days or more.

[0076] The pre-irradiative heating can be sufficient to form a substantially homogenous distribution of the antioxidant in a surface layer of the antioxidant-diffused solid material. The surface layer can be a layer of any suitable depth as measured from the outside of the material, such as about 0 mm to about 1 mm deep, about 0 mm to about 10 mm deep, about 1 mm to about 10 mm deep, about 0 mm to about 20 mm deep, about 1 mm or less, or about 1.5 mm, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 6,5, 7, 7.5, 8, 8.5, 9, 9.5, 10, 1 1, 12, 13, 14, 15, 16, 17, 18, 19, or about 20 mm deep or more. The pre-irradiative heating can be sufficient to allow the antioxidant (e.g., at least some of the antioxidant) to penetrate to a depth of at least about I mm from a surface (e.g., a surface where antioxidant was coated) of the antioxidant-diffused solid material, or about 2 mm, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, or about 20 mm from a surface.

[0077] The pre-irradiative heating can optionally include cooling prior to the irradiation

(e.g., prior to an optional preheating step, or directly prior to the irradiation). The cooling can be to any temperature below the melting point of the heated material, such as to room temperature. The cooling can occur in ambient conditions, or the cooling can occur in a chilled environment. The cooling can occur in any medium, such as in a gas (e.g., air) or in a liquid (e.g., water). Preheating.

[0078] The method can include preheating prior to irradiation (e.g., warm-irradiating). In other embodiments, the method can be free of preheating prior to irradiation. The preheating can be the same as the pre-irradiative heating, or the preheating and the pre-irradiative heating can be different heating steps. In some embodiments, the pre-irradiative heating can be preheating to or above a preheat temperature, to provide a preheated antioxidant-diffused solid material, wherein the irradiating includes irradiating the preheated antioxidant diffused solid material. In some embodiments, the pre-irradiative heating and preheating can be separate steps, wherein after the pre-irradiative heating the antioxidant-diffused solid material that was pre-irradiatively heated is preheated to at or above a preheat temperature to provide a preheated antioxidant-diffused solid material, wherein the irradiating includes irradiating the preheated antioxidant-diffused solid material.

[0079] In some embodiments, the preheating can include heating to a temperature above room temperature and below or above the melting point of the UHMWPE or mixture of

UHMVVPE and other components, such as about 50 °C to about 300 °C, about 80 °C to about 250 °C, about 130 °C to about 160 °C, about 50 °C or less, or about 55 °C, 60, 65, 70, 75, 80, 85, 90, 95, 100, 105, 110, 1 15, 120, 125, 130, 140, 145, 150, 160, 170, 180, 190, 200, 220, 240, 260, 280, or about 300 °C or more, such that at the time of irradiation onset the material has a preheated temperature. The preheating can be performed for any suitable amount of time, such as about 1 minute to about 7 days, or about 1 hour to about 48 hours, or about 1 minute or less, or about 2 minutes, 3, 4, 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55 minutes, 1 hour, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 1 5, 16, 17, 18, 19, 20, 21, 22, 23 hours, 1 day, 1.5, 2, 2,5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 6.5 days, or about 7 days or more.

Irradiating.

[0080] The method includes irradiating the antioxidant-diffused material, to provide an irradiated solid material. The antioxidant-diffused material can be preheated, or no preheating occurs prior to irradiation (e.g., the antioxidant-diffused material can be approximately ambient temperature or room temperature when irradiation begins). The irradiating can crosslink the UHMWPE in the antioxidant-diffused solid material.

[0081] The irradiation can be any suitable irradiation. The irradiation can be visible light radiation, infrared radiation, ultraviolet radiation, electron beam radiation, gamma radiation, or X-ray radiation. Where ionizing radiation is employed to effect the crosslinking reaction, the radiation can be obtained from any suitable source such as an atomic pile, a resonant transformer accelerator, a Van de Graaff electron accelerator, a Linac electron accelerator, a betatron, a synchrotron, a cyclotron, or the like. Radiation from these sources will produce ionizing radiation such as electrons, protons, neutrons, deuterons, gamma rays, X-rays, alpha particles, or beta particles. Where ionizing radiation is used, a sufficient radiation dose rate and absorbed dose can be used to induce crosslinking and/or control the degree of crosslinking. In some embodiments, during the irradiation, the temperature of the UHMWPE or mixture of UHMWPE and other components can be maintained below the melting point of the same, in some embodiments, during the irradiation, the temperature of the UHMWPE or mixture of UHMWPE and other components can be allowed to rise above the melting point of the same. In various embodiments, during irradiation, the temperature can be allowed to rise to, or the temperature can be maintained at, about 60 °C, 65, 70, 75, 80, 85, 90, 95, 100, 105, 110, 1 15, 120, 125, 130, 135, 140, 145, 150, 155, 160, 165, 170, 175, 180, 185, 190, 195, 200, 210, 220, 230, 250, 275, or about 300 °C or more. In various embodiments, the UHMWPE or mixture of UHMWPE and other components can be preheated to a temperature below the melting point of the same, then subsequently irradiated while maintaining the temperature of the preheated UHMWPE or mixture of UHMWPE and other components below the melting point of the same.

[0082] In various embodiments, the irradiating, such as electron-beam irradiation or gamma irradiation, uses a total dose of about 1 kGy to about 100,000 kGy, 10 kGy to about 1000 kGy, about 50 kGy to about 500 kGy, 50 kGy to 300 kGy, or about 1 kGy or less, or about 5, 10, 15, 20, 25, 50, 75, 100, 125, 150, 175, 200, 250, 300, 350, 400, 500, 750, 1,000, 1 ,250, 1,500, 1,750, 2,000, 2,500, 3,000, 4,000, 5,000, 7,500, 10,000, 15,000, 20,000, 25,000, 50,000, 75,000, or about 100,000 kGy or more. In various embodiments, the irradiating includes using a dose rate of about 0.001 niGy/h to about 500 MGy/h, about 1 mGy/h to about 50 MGy/h, or about

0.001 mGy/h or less, or about 0.005 mGy/h, 0.01, 0.05, 0.1, 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 22, 24, 26, 28, 30, 35, 40, 45, 50, 60, 70, 80, 90, 100, 150, 200, 250, 300, 400, or about 500 MGy/h or more.

[0083] In certain examples, irradiative crosslinking can be performed in the presence of an additive that can promote or deter crosslinking, depending on the desired level of

crosslinking. Illustrative crosslinking promoters include, but are not limited to,

trimethyloipropane triacrylate, trimethyiolpropane trimethacrylate, pentaerythritol tetraacryiate, and pentaerythritol tetramethacrylate.

Melt-stabilizing.

[0084] The method can include post-irradiatively heating the irradiated solid material.

The post-irradiative heating is sufficient to melt at least part of the UHMWPE. The post- irradiative heating provides a heated material. The method can include solidifying the heated material, to provide a melt-stabilized material.

[0085] The post-irradiative heating can melt any suitable amount of the irradiated solid material, or of the UHMWPE in the irradiated solid material, such as about 1 vol% to about 100 vol%, or about 1 vol% or less, or about 2 vol%, 3, 4, 5, 6, 7, 8, 9, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, 95, 96, 97, 98, or about 99 vol% or more. The heating is sufficient to melt-stabilize the irradiated solid materi al, such that at least some of the free radicals (e.g., free radicals in the UHMWPE, which can be generated during irradiation) can recombine or otherwise be neutralized.

[0086] The method can include post-irradiatively heating the irradiated solid material in an environment including oxygen, the heating sufficient to melt at least part of the UHMWPE, to provide a heated material. In some embodiments, the method includes heating the irradiated solid material in an environment substantially free of oxygen. Various embodiments of the present invention provide a means to reduce the oxidized layer that forms during melt- stabilization of a material including UHMWPE in an oxygen-containing environment such as air. During the melt-stabilization, the antioxidant can scavenge the free radicals present in the outer layer that would normally be oxidized. The heating can occur in an environment including any suitable amount of oxygen. For example, the heating can occur in an environment including ambient air, having about 20-21 vol% oxygen. The heating can occur in an environment having about 1 vol% to about 50 vol% oxygen, about 10 vol% to about 30 vol% oxygen, about 1 vol% oxygen or less, or about 2 vol%, 3, 4, 5, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 46, 48, or about 50 vol% oxygen or more,

[0087] The post-irradiative heating heats the irradiated solid material to any suitable temperature, such as about 50 °C to about 300 °C, about 80 °C to about 250 °C, about 130 °C to about 160 °C, about 50 °C or less, or about 60 °C, 70, 80, 90, 100, 1 10, 120, 130, 140, 150, 160, 170, 180, 190, 200, 220, 240, 260, 280, or about 300 °C or more. The irradiated solid material can be heated for any suitable duration, such as about 1 minute to about 7 days, or about 1 hour to about 48 hours, or about 1 minute or less, or about 2 minutes, 3, 4, 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55 minutes, I hour, 1 ,5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 6, 7, 8, 9, 10, 1 1, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21 , 22, 23 hours, 1 day, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 6.5 days, or about 7 days or more,

[0088] The solidifying can be any suitable solidifying, such that the melted material is allowed to solidify. The solidifying can include allowing the post-irradiatively heated material to cool to a temperature below the melting point of the heated material, such as to room

temperature. The solidifying can occur in ambient conditions, or the solidifying can occur in a chilled environment. The solidifying can occur in any medium, such as in a gas (e.g., air) or in a liquid (e.g., water).

[0089] The method can be effective to generate a melt-stabilized material including

UHMWPE, melt-stabilized in an environment including oxygen, that has decreased or no oxidation in a surface layer of the material, as compared to other methods for melt-stabilization in an oxygen-containing environment. The surface layer including decreased or no oxidation can be a surface layer that corresponds to the entire outer surface of the material, such as for a material including UHMWPE on the entire surface of the material (e.g., the material can be 100% UHMWPE or can have UHMWPE distributed evenly throughout). The surface layer can be a portion of the outer surface that corresponds to a portion of the outer surface of the material, such as for a material including UHMWPE on only a portion of the surface of the material, or such as for a material that was only partially coated with the liquid composition including the antioxidant. The surface layer can be a layer of any suitable depth as measured from the outside of the material, such as about 0 mm to about 1 mm deep, about 0 mm to about 10 mm deep, about 1 mm to about 10 mm deep, about 0 mm to about 20 mm deep, about 1 mm or less, or about 1.5 mm, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 6.5, 7, 7.5, 8, 8.5, 9, 9.5, 10, 1 1 , 12, 13, 14, 15, 16, 17, 18, 19, or about 20 mm deep or more.

[0090] The irradiated solid material can have a first concentration of free-radicals. The first concentration of free-radicals can be any suitable concentration, such as about 1 x 10 ¹⁵ spins/gram to about 1 x 10 ²⁰ spins/g, 1 x 10 ^!6 spins/g to 1 x 10 ^!8 spins/g, or about 1 x 10 ^l5 spin/g or less, or about 1 x 10 ¹⁶ spins/g, 1 x 10 ¹⁷ , 1 x 10 ⁱ⁸ , 1 x 10 ⁱ⁹ , 1 x 10 ²⁰ , 1 x 10 ²¹ , 1 x lO ²² , 1 x 10 ²³ , 1 x 10 ²⁴ , 1 x 10 ²⁵ , 1 x 10 ²⁶ , 1 x 10 ' ^" , 1 x 1 Q ²⁸ , 1 x 10 ²⁹ , or about 1 x 10 ³⁰ spins/g or more. The number of spins per gram of the material can be measured in any suitable fashion, such as by electron spin resonance (ESR). The first concentration of free-radicals can be a concentration in the UHMWPE or a concentration in the irradiated solid including the UHMWPE. The first concentration of free-radicals can be a concentration in a part or localized area of the material, or can be a concentration throughout the entire material including the UHMWPE. In some embodiments, the first concentration of free-radicals can be generated by and consistent with an amount of irradiation applied to the antioxidant-diffused solid material to crosslink the

UHMWPE or to crosslink other components in the antioxidant-diffused solid material.

[0091] The method can include solidifying the post-irradiatively heated material, to provide a melt-stabilized material including UHMWPE including a second concentration of free- radicals, wherein the second concentration of free-radicals is less than the first concentration of free-radicals. The melt-stabilization can reduce the concentration of free-radicals. The concentration of free-radicals in the UHWMPE can be reduced. The concentration of free- radicals in other materials can also optionally be reduced, for materials including other materials in addition to UHMWPE, such as other polyethylenes or other polymers. The second

concentration of free-radicals in the melt-stabilized material can be any suitable concentration that is lower than the first concentration of free radicals, such as about 1 x 10 ⁵ spins/g to about 1 x 10 ¹³ spins/g, or about 1 x 10 ² spins/g or less, or about 1 x 10 ³ spins/g, 1 x lO ⁴ , 1 x 10 ⁵ , 1 x 10 ⁶ , 1 x 10 ⁷ , 1 x l O ⁸ , 1 x 10 ⁹ , 1 x 10 ^!0 , 1 x 10 ^{! !} , 1 x 10 ¹² , 1 x 10 ¹³ , 1 x 10 ¹⁴ spins/g, 1 x 10 ¹⁵ spins/g or more. The number of spins per gram of the material can be measured in any suitable fashion, such as by electron spin resonance (ESR). The second concentration of free-radicals can be a concentration in the UHMWPE or a concentration in ail the materials the melt-stabilized material including the UHMWPE, corresponding to the part or localized area where the first

concentration of free-radicals is determined. The second concentration of free-radicals can be a concentration in a part or localized area of the material (e.g., corresponding to a part or localized area where the first concentration of free-radicals is measured), or can be a concentration throughout the melt-stabilized material including the UHMWPE. The second concentration of free-radicals can be any suitable proportion of the first concentration of free-radicals. For example, the second concentration of free-radical s can be about 1 % to about 0.000,1% of the first concentration of free-radicals, about 0.1% to about 0.001%, or about 1% or more, or about 0.5 %, 0.1, 0,05, 0.01, 0.005, 0.001 , 0.000,5, or about 0.000,1% or less.

[0092] As used herein, "oxidation index" refers to an area ratio of fourier transform infrared (FTIR) peaks at 1765-1680 cm ^"1 (e.g. carbonyl peaks) to FTIR peaks 1392-1330 cm ^"1 (e.g., methyl peaks), wherein the area of the carbonyl absorptions centered near 1720 cm ^"1 is related to the amount of chemically bound oxygen present in the material, and the intensity (area) of the C-H absorption centered near 1370 cm ^"? is used to normalize for the sample's thickness. A surface layer (e.g., the entire surface, or only part of the surface, of any suitable depth) of the melt-stabilized material can have an oxidation index that does not exceed 1 (e.g., the average oxidation index of the surface layer does not exceed an oxidation index of I or any portion of the surface layer does not exceed an oxidation index of 1). For example, in some embodiments, the surface layer of the melt-stabilized material has an oxidation index that does not exceed 0.5, or that is about 0.001 to about 1 , 0.01 to about 0.5, or about 0.001 or less, or that is equal to or less than about 0.002, 0.003, 0.004, 0.005,0.006, 0.008, 0.01, 0.015, 0.02, 0.025, 0.03, 0.035, 0.04, 0.045, 0.05, 0.055, 0,06, 0,065, 0.07, 0.075, 0.08, 0.085, 0.09, 0.095, 0, 1 , 0.15, 0,2, 0.25, 0,3,

0.35, 0.4, 0.45, 0.5, 0.6, 0.7, 0.8, 0.9, or about 1 or more. The surface layer can be a layer of any suitable depth on the material, such as about 0 mm deep (e.g., the top surface most exposed to oxygen), or a layer about 0 mm deep to about 1 mm deep, about 0 mm deep to about 10 mm deep, or about 1 mm deep or less, or about 2 mm, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, or about 20 mm deep or more.

[0093] The melt-stabilized material can have any suitable concentration of antioxidant at various depths from the surface of the material. For example, the coating, pre-irradiative heating, irradiating, and melt-stabilizing (e.g., post-irradiative heating and solidifying) can be sufficient such that the melt-stabilized material has a vitamin E index (VEI, the FTIR ratio of the peak areas between 1275 and 1245 cm ^"1 to the peak areas between 1985 and 1850 cm ^"1 ) in a surface layer of about -0.1 to about 0.5, about -0.05 to about 0.25, about 0.01 to about 0.25, about 0.05 to about 0.25, about 0.1 to about 0.25, or about -0.1 or less, or about -0.08, -0.06, - 0.04, -0.02, -0.01, 0, 0.01, 0,02, 0.04, 0.06, 0.08, 0.1, 0.12, 0.14, 0.16, 0.18, 0.2, 0.22, 0.24, 0.26, 0.28, 0.3, 0.35, 0.4, 0.45, or about 0.5 or more. The surface layer can be a layer of any suitable depth on the material, such as about 0 mm deep (e.g., the top surface most exposed to oxygen), or a layer about 0 mm deep to about 1 mm deep, about 0 mm deep to about 10 mm deep, or about 1 mm deep or less, or about 2 mm, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, or about 20 mm deep or more. In some embodiments, the VEI can be a gradient that is highest at a depth of 0 mm and that becomes lower at deeper depths. In some embodiments, the VEI can be substantially similar throughout the surface layer or throughout the melt-stabilized material.

[0094] The melt-stabilized material can have any suitable concentration of the coated and diffused antioxidant at various depths from the surface of the material, such as an antioxidant (e.g., vitamin E), or such as another component. For example, the coating, pre-irradiative heating, irradiating, and melt-stabilizing (e.g., post-irradiative heating and solidifying) can be sufficient such that the melt-stabilized material has a concentration of an antioxidant such as vitamin E in a surface layer of about 0.001 wt% to about 10 wt%, about 0.01 wt% to about 5 wt%, about 0.1 wt% to about 2.5 wt%, about 0.1 wt% to about 1 wt%, or about 0,001 wt% or less, or about 0.01, 0.1, 0.2, 0.4, 0.6, 0.8, 1, 1.2, 1.4, 1.6, 1.8, 2, 2.4, 2.6, 2.8, 3, 3.5, 4, 4.5, 5, 6, 7, 8, 9, or about 10 wt% or more. The surface layer can be a layer of any suitable depth on the material, such as about 0 mm deep (e.g., the top surface most exposed to oxygen), or a layer about 0 mm deep to about 1 mm deep, about 0 mm deep to about 10 mm deep, or about I mm deep or less, or about 2 mm, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, or about 20 mm deep or more. In some embodiments, the concentration of the antioxidant can be a gradient (linear or non-linear) that is highest at a depth of 0 mm and that becomes lower at deeper depths. In some embodiments, the concentration of the component can be substantially similar throughout the surface layer or throughout the melt-stabilized material.

UHMWPE material and medical implant including the same.

[0095] In various embodiments, the present invention provides a melt-stabilized material made by any suitable embodiment of a method described herein. For example, in various embodiments, the present invention provides an oxygen-containing-environment-melt-stabilized material including UHMWPE and an antioxidant, the antioxidant introduced prior to an irradiation step, the melt-stabilized material being free of post-melt-stabilization oxidized surface layer removal greater than about 1 mm depth, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 6.5, 7, 7.5, 8, 8.5, 9, 9.5, or greater than about 10 mm depth, wherein the UHMWPE in a surface layer (e.g., about 0 mm deep, or a layer about 0 mm deep to about 1 mm deep, about 0 mm deep to about 10 mm deep, or about 1 mm deep or less, or about 2 mm, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, or about 20 mm deep or more) of the melt-stabilized material (e.g., the material after any surface layer removal ) has an oxidation index that does not exceed 1.

[0096] In various embodiments, the present invention provides a medical implant including any suitable melt-stabilized material including UHMWPE that can be produced by an embodiment of the method described herein. The method of melt-stabilizing UHMWPE can include generating a medical implant from the resulting material, such that the method is a method of making a medical implant. In some embodiments, various amounts of the surface of the melt-stabilized material can be removed during processing and machining the material into the desired shape for the implant, such as about 0 mm to about 1 mm, about 0 mm to about 5 mm, about 0 mm to about 10 mm, about 0.1 mm or less, or about 0.5 mm, I, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 6.5, 7, 7,5, 8, 8.5, 9, 9.5, 10, 1 1, 12, 13, 14, 15, 16, 17, 18, 19, or about 20 mm or more. In some embodiments, the medical implant can be an orthopedic implant. In various embodiments, the medical implant can form or be part of an artificial hip, hip liner, knee, knee liner, disk replacement, shoulder, elbow, foot, ankle, finger, mandible, or bearings in an artificial heart.

Examples

[0097] Various embodiments of the present invention can be better understood by reference to the following Examples which are offered by way of illustration. The present invention is not limited to the Examples given herein.

[0098] Oxidation levels were determined through the blocks at center from top to bottom and side to side of each block, bottom denoting the surface the block was setting on during the melt stabilization process. The FTIR Oxidation Index (OI) was determined per ASTM F2102- 06. Following the ASTM F2102-06 protocol, 100-200 micron thick films were microtomed from the block of material, with the top indicative of the initial incident irradiation face. The film was scanned with an FTIR spectrophotometer using an indexing microscopic attachment to obtain infrared spectra at 200 micron intervals across the entire length of the film. The oxidation index at various locations scanned was then calculated using the ratio of the oxidation peak ( 1765-1680 cm ^'1 , centered at 1720 cm ^"1 ) to a control peak that does not change with irradiation (1392-1330 cm ^"1 , centered at 1370 cm ^"1 ).

[0099] The trans-vinylene index throughout the Examples is determined as the area of the infrared absorption peak centered near 965 cm ^"1 to the area of the of the C-H absorption peak centered near 1370 cm ^"1 . The area of the trans-vinylene absorptions (-C=C-) centered near 965 cm ^'1 is related to the amount of crossiinking experienced by the material when exposed to ionizing radiation. Polymer main chain un saturation in the form of trans-vinyl groups are a side reaction during crossiinking via ionizing radiation such as gamma, x-ray and electron beam. The correlation between TVI and actual received radiation dose can depend on the nature of the irradiation conditions, for example, radiation source (gamma or electron beam), temperature, dose rate, and oxygen level. The amount of unsaturation formation can be directly correlated with the amount of irradiation (e.g., dose), and can be used as a dosimeter for a given material and irradiation method combination.

[00100] The vitamin E-phosphite was synthesized as follows. The equipment used included (1) three neck schlenk style round bottom 100 ml flask; (1) gas inlet, schlenk; (1) addition funnel, schlenk; (1) reflux condenser, schlenk, (1) filter funnel, 25-50 um glass frit disc, schlenk; (1) single neck collection flask, 100 ml, schlenk; (1) distillation adapter, schlenk; (1) water chilled condenser, schlenk; (1) single neck collection flask, 50 ml, schlenk; (1) magnetic stir bar to fit 100 ml round bottom flask; (1) pipet, 5 ml; (1) pipet, 1 ml; (1) pipet bulb; (1 ) lab scale, resolution > 0.001 g; (1) hot plate with magnetic stir capability; and (1) glass jar with large stir bar for use as heating bath. The materials also included all racemic d,l-a-tocopherol; HPLC grade dichloromethane; triethyiamine, assay > 99%; Aldrich grade reagent-plus PC1 ₃ , assay > 99%; molecular sieves, type 3 A, 8-12 mesh; dry nitrogen gas, and heat transfer oil.

Activated molecular sieves, type 3 A, 8-12 mesh were dried 4 hours @ 220 C, cooled 1 hour @ J 10 C, and returned to dried glass container. Fisher HPLC grade dichloromethane and Sigma- Aidrich triethyiamine, assay > 99%,were dried over activated molecular sieves prior to use. All glassware was dried before use by gently warming with a hot air gun or oven, taking care not to overheat the schlenk connections to cause distortion. A 100 ml three neck Schlenk-style flask was set up containing a magnetic stir bar and fitted with a gas inlet and addition funnel. The flask was charged with 3.79 x 10 ^"2 mole (16.3424 g) of d,l-a-tocopherol. The tocopherol was dissolved under a dry nitrogen purge with 15 ml dry dichloromethane. Triethylamine (5.5 ml) was pipeted into the flask (about 3.95 x 10 ^"2 mole) under dry purge with stirring.

Dichloromethane (10 ml) was added to the addition funnel under dry nitrogen purge. PCI3 was added (1.198 x 10 ^" mole, 1.05 ml) under dry purge into the addition funnel containing the 10 ml of dichloromethane (95% of calculated stoichiometry based on amount of tocopherol). The diluted PCI3 solution was added drop-wise to the reaction flask with stirring under dry purge (a precipitate will form). The Schlenk-style addition funnel used for the PCI3 addition was rinsed into the reaction flask with three additional 5 ml aliquots of dichloromethane to insure complete transfer of the PCI3. The reaction flask was stirred for one hour at ambient temperature under dry nitrogen purge. The reaction flask was slowly heated with stirring to 60 °C with a reflux condenser attached to the flask maintaining the dry nitrogen purge and maintain for one hour at 60 °C. Precipitate was filtered off using dry nitrogen purge/vacuum with 25-50 um glass frit disc filter, and 100 ml collection flask, Schlenk. The single neck 100 ml collection flask used to collect the product was fitted with a distillation adapter, water chilled condenser, vacuum adapter and 50 ml collection flask. To remove volatiles, the 100 ml collection flask was heated to 100 °C overnight under dry nitrogen purge with stirring, then a vacuum was applied for one hour maintaining the 100 °C temperature with stirring. The remaining product was hot filtered using dry nitrogen purge/vacuum with 25-50 μτη glass frit disc filter, and 100 ml tared collection flask, Schlenk. The filtrate was cooled to ambient under dry nitrogen purge. The product weight was 7.1 g (clear, amber liquid). The product was diluted quantitatively to a 10% by weight solution in dry dichloromethane. The diluted product was stored under dry nitrogen in a sealed glass container, in a dessicator. Remaining VE-Phosphite in glassware was recovered, after sitting several weeks in air and light, by dilution with dry dicholormethane and subsequent filtering. The recovered product weight was 6.3 g (clear, amber liquid).

Example I

[00101] Four sections of a GUR 1050 compression molded bar were treated as follows:

Sample 1.1.1 : No coating.

Sample 1.1.2: Coated with a solution of 10% vitamin E (VE) dissolved in isopropanol. Sample 1.1.3 : Coated with a solution of 10% vitamin E-phosphite (VEP) dissolved in dichlorom ethane.

Sample 1.1.4: Coated with a solution of 0% recovered vitamin E-phosphite (VEP-R) dissolved in dichloromethane.

[00102] The recovered VEP was obtained by a secondary cleaning of the glassware used for synthesis of the VEP, which had some increased exposure to oxygen during recovery as compared to the VEP which was maintained under an inert environment until application to the UHMWPE section.

[00103] All sections were individually placed in a metallized mylar bag under nitrogen purge to prevent oxygen infiltration. The bagged sections were then heated to 120 °C for 14 hours, irradiated warm (120 °C) with 75 kGy using a 10 MeV electron beam. After cooling in the mylar bags purged with nitrogen, the sections were removed from the inert atmosphere and were melted at 150 °C for 14 hours in air, followed by slow cooling (16 hours) to ambient temperature, in air.

[00104] The Samples were sectioned, then films were prepared with a microtome from top to bottom of each sectioned form, and from side to side of each sectioned form, and analyzed for trans-vinyl index and oxidation index per ASTM F2381-10 and ASTM F2102- 13, respectively.

[00105] Table 1 illustrates oxidation index to a depth of 5 mm as measured from the top, bottom, and both sides of Samples 1.1.1-1.1.4.

[00106] Table 1. Oxidation index for Samples 1.1 , 1 -1.1.4.

2600 0.062 0.058 0.068 0,064 0.032 0.019 0.034 0.040

2800 0.062 0.055 0.057 0,058 0.033 0.018 0.034 0.041

3000 0.057 0.048 0.054 0.052 0.034 0.018 0.034 0.039

3200 0.054 0.049 0.050 0.042 0.034 0.019 0.034 0.038

3400 0.048 0.046 0.047 0.043 0.034 0.019 0.035 0.038

3600 0.041 0.044 0,040 0.039 0.036 0.039 0.034 0.038

3800 0.038 0.039 0,034 0.029 0.034 0.020 0.035 0.036

4000 0.033 0.036 0,032 0.031 0.035 0.020 0.035 0.037

4200 0.033 0.034 0.028 0.025 0.035 0.020 0.036 0,036

4400 0.027 0.018 0.030 0.025 0.035 0.020 0.035 0,035

4600 0.027 0.025 0.026 0.022 0.035 0.021 0.036 0.035

4800 0.024 0.026 0.023 0.015 0.036 0.021 0.036 0.035

5000 0.039 0.027 0.020 0,014 0.035 0.022 0.035 0.035

Sample Dept Top Btm OI Side 1 Side 2 Top Btm Side Side 2 AO

Ιι, μ OI OI OI TVI TVI 1 TVI TVI Treatment

1.1.2 0 0.045 0.036 0.027 0.026 0.035 0.011 0.043 0.053 Vitamin E

200 0.054 0.034 0.019 0.022 0.035 0.011 0.034 0.034

400 0.047 0.032 0.021 0.024 0.035 0.011 0.033 0.033

600 0.046 0.028 0,021 0.024 0,035 0,011 0.033 0.032

800 0.042 0.029 0,025 0.024 0,035 0.011 0.034 0.032

1000 0.043 0.029 0,028 0.023 0,036 0,012 0,033 0,032

1200 0.042 0.033 0.028 0.019 0.037 0.012 0,033 0,032

1400 0.039 0.032 0.025 0.017 0.037 0.014 0,033 0,032

1600 0.035 0.026 0.020 0.010 0.036 0.013 0.033 0.031

1800 0.033 0,025 0.018 0,007 0.037 0.014 0.033 0.031

2000 0.038 0.017 0.017 0,006 0.036 0.013 0.033 0.031

2200 0.071 0,025 0.016 0,007 0.035 0.014 0.033 0.033

2400 0.1 16 0,020 0.021 0,006 0.034 0.014 0.034 0.033

2600 0.098 0.017 0.023 0.008 0.035 0.015 0.035 0.033

2800 0.061 0.017 0.032 0.007 0.036 0.016 0.034 0.033

3000 0.109 0.018 0.042 0.020 0.038 0.016 0.034 0.033

3200 0.155 0.017 0,064 0.048 0,039 0,016 0.034 0.033

3400 0.154 0.019 0,083 0. 07 0,039 0,016 0.034 0.034

3600 0.027 0.017 0, 125 0.152 0,036 0,017 0.035 0.035

3800 0.012 0.018 0, 132 0.120 0,035 0,018 0,038 0,035

4000 0.013 0.019 0.102 0.050 0.036 0.017 0,037 0,035

4200 0.012 0.019 0.033 -0.001 0.035 0.019 0.036 0.035

4400 0.009 0.019 0.010 -0.007 0.035 0.019 0.036 0.035

4600 0.009 0,018 0.009 -0.006 0.036 0.020 0.035 0.035

4800 0.001 0,015 0.005 -0.007 0.036 0.019 0.036 0.035

5000 0.002 0.021 0.002 -0.007 0.035 0.020 0.036 0.036

Sample Dept Top Btm OI Side l Side 2 Top Btm Side Side 2 AO ϊί, μ OI OI OI TVI TVI 1 TVI TVI Treatment

1.1.3 0 -0.009 0.052 0.009 0,022 0.049 0.029 0.052 0.044 VE-

200 0.002 0.057 0.007 0.035 0.046 0.029 0.047 0.042 Phosphite

400 0.009 0.055 0.016 0.035 0.046 0.027 0.046 0.042

600 0.008 0.040 0.022 0.034 0.046 0.025 0.046 0.041

800 0.006 0.038 0,019 0.027 0,044 0,026 0.045 0.039

1000 0.002 0.037 0,015 0.026 0,043 0,024 0.043 0.038

200 -0.002 0.038 0.011 0.026 0.041 0,023 0.041 0.037

1400 -0.006 0.040 0.007 0.032 0.041 0,023 0.039 0.036

1600 -0.007 0.035 0.004 0.040 0.039 0,023 0.037 0.035

1800 -0.009 0.031 0.007 0.040 0.039 0.021 0.038 0.035

2000 -0.009 0.025 0.009 0.044 0.038 0.021 0.037 0.035

2200 -0.006 0,022 0.012 0,062 0.037 0.020 0.036 0.034

2400 -0.007 0 ^ 3 0.015 0,037 0.038 0.019 0.035 0.035

2600 -0.027 0.023 0.016 0,033 0.037 0.018 0.035 0.034

2800 -0.006 0.032 0.018 0,031 0.036 0.017 0.035 0.036

3000 -0.008 0.052 0.027 0,042 0.037 0.018 0.035 0.036

3200 0.000 0.052 0.032 0.055 0.036 0.020 0.035 0.037

3400 0.013 0.046 0.046 0.133 0.037 0.018 0.037 0.039

3600 0.030 0.068 0.079 0.085 0,037 0,021 0.038 0.038

3800 0.058 0.094 0, 133 0.014 0,037 0,022 0.039 0.035

4000 0.074 0.067 0,024 0.006 0,039 0,022 0,037 0,035

4200 0.057 0.030 0.001 0.006 0,039 0,019 0.035 0.035

4400 -0.009 0.038 -0.002 0.005 0,037 0,019 0.035 0.036

4600 -0.014 0.030 0.000 0.003 0.036 0.019 0.035 0.035

4800 -0.015 0.022 -0.001 0.003 0.037 0.018 0.036 0.036

5000 -0.016 0,022 0.000 0,002 0.036 0.020 0.036 0.036

Sample Dept Top Btm OI Side l Side 2 Top Btm Side Side 2 AO

Ιι, μ OI OI OI TVI TVI 1 TVI TVI Treatment

1.1.4 0 0.022 0.041 0.019 0,036 0.068 0.030 0.052 0.056 VE-

200 0.027 0.042 0.022 0.036 0.056 0.030 0.049 0.049 Phosphite-

R

400 0.030 0.043 0,030 0.043 0,055 0,030 0.049 0.048

600 0.031 0.045 0,028 0.039 0,056 0,027 0.049 0.045

800 0.028 0.050 0,026 0.037 0,053 0,027 0.047 0.044

1000 0.022 0.046 0,027 0.030 0.051 0,027 0,045 0,042

1200 0.016 0.047 0.021 0.028 0.049 0,026 0.044 0.041

1400 0.012 0.040 0.018 0.023 0.046 0.024 0.042 0.038

1600 0.011 0.042 0.015 0.022 0.044 0.023 0.040 0.038

1800 0.008 0,043 0.012 0,022 0.043 0.022 0.039 0.037

2000 0.032 0,039 0.016 0,021 0.041 0.020 0.038 0.036

2200 0.010 0,039 0.012 0,019 0.039 0.017 0.037 0.035

2400 0.011 0,038 0.012 0,018 0.038 0.019 0.036 0.036 2600 0.009 0,043 0.009 0,019 0.038 0.018 0.037 0.035

2800 0.007 0,041 0.009 0,020 0.037 0.017 0.036 0.035

3000 0.006 0.062 0.010 0,022 0.036 0.018 0.036 0.035

3200 0.006 0.086 0.014 0.024 0.037 0.019 0.037 0.034

3400 0.007 0.104 0.021 0.022 0.036 0.022 0.037 0.036

3600 0.005 0.279 0,017 0.022 0,037 0,026 0.037 0.034

3800 0.005 0.055 0,030 0.037 0,036 0,020 0.038 0.036

4000 0.011 0.025 0,086 0.257 0,037 0,017 0.039 0.037

4200 0.013 0.023 0.240 0.199 0,036 0,018 0,039 0,038

4400 0.017 0.026 0.027 0.026 0,037 0,018 0,038 0,036

4600 0.069 0.028 0.002 0.018 0.038 0.019 0.037 0.035

4800 0.079 0.029 0.004 0.020 0.037 0.019 0.037 0.035

5000 0.054 0,022 0.000 0,024 0.038 0.019 0.037 0.036

Example 2.

[00107] Four sections of a GUR 1050 compression molded bar were treated as follows:

Sample 2.1.1 : No coating.

Sample 2.1.2: Coated with a solution of 10% vitamin E (VE) dissolved in isopropanol, coated with a solution of 10% vitamin E-phosphite (VEP) dissolved in

di chl or om ethane .

Sample 2.1.3 : Coated with a solution of 10% vitamin E-phosphite (VEP)dissolved in dichloromethane.

Sample 2.1.4: Coated with a solution of 10% recovered vitamin E-phosphite (VEP-R) dissolved in dichloromethane.

[00108] The recovered VEP was obtained by a secondary cleaning of the glassware used for synthesis of the VEP, which had some increased exposure to oxygen during recovery as compared to the VEP which was maintained under an inert environment until application to the UHMW PE secti on .

[00109] Ail sections were then heated to 120 ^C 'C for 14 hours in air, irradiated warm (120

°C) in air with 75 kGy using a 10 MeV electron beam. After cooling in air, the sections were melted at 150 °C for 14 hours in air, followed by slow cooling (16 hours) to ambient temperature, in air. [00110] The Samples were sectioned, then films were prepared with a microtome from top to bottom of each sectioned form, and from side to side of each sectioned form, and analyzed for trans-vinyl index and oxidation index per ASTM F2381-10 and ASTIVi F2102- 13, respectively.

[00111] Table 2 illustrates oxidation index to a depth of 5 mm as measured from the top, bottom, and both sides of Samples 2.1.1-2.1 ,4.

[00112] Table 2. Oxidation index for Samples

Sample Depth, Top OI Btm Side 1 Side 2 Top Btm Side Side AO Treatment μ OI OI Ol TV! TVI 1 TVI 2

TVI

2.3.1 1 0 5. 186 5.623 4.650 7,287 0,035 0.056 0.031 0.049 None

1 200 1.380 2.811 1.244 3,662 0,025 0.025 0.024 0.027

1 400 0.520 0.899 0.463 1,099 0,029 0.019 0.029 0.024

1 600 0.244 0.437 0.167 0,430 0,032 0.016 0.030 0.029

1 800 0.132 0.270 0.126 0,225 0.032 0.015 0.030 0.030

1 1000 0.115 0.157 0.3 15 0.189 0.032 0.014 0,030 0.030

1 1200 0.105 0.099 0. 303 0.352 0.032 0.012 0,030 0.029

1 1400 0.105 0.070 0. 301 0.340 0.031 0.012 0.030 0.029

1 1600 0.089 0.054 0.097 0.126 0.031 0.012 0.029 0,030

1 1800 0.088 0.044 0.087 0.127 0.032 0.012 0.030 0,029

1 2000 0.071 0.036 0.082 0.107 0.032 0.013 0.031 0,030

I 2200 0.068 0.029 0.078 0.096 0.032 0.013 0.030 0.030

I 2400 0.064 0.026 0.072 0.086 0,033 0.034 0.031 0.030

1 2600 0.052 0.026 0.060 0,078 0,033 0.034 0.031 0.030

1 2800 0.049 0.022 0.058 0,075 0,033 0.014 0.031 0.030

1 3000 0.043 0.021 0.052 0,062 0,033 0.015 0.032 0.031

1 3200 0.036 0.018 0.045 0.061 0,033 0.016 0.032 0.031

1 3400 0.034 0.017 0.038 0.051 0.034 0.015 0.032 0.031

3600 0.027 0.019 0.037 0.045 0.033 0.016 0.033 0.032

1 3800 0.023 0.017 0.031 0.045 0.033 0.017 0.032 0.032

1 4000 0.022 0.016 0.036 0.039 0.032 0.017 0.034 0.032

4200 0.025 0.015 0.029 0.038 0.034 0.017 0.032 0.033

1 4400 0.015 0.020 0.030 0.029 0.035 0.017 0.033 0,033

1 4600 0.013 0.013 0.018 0.029 0.034 0.018 0.037 0,033

1 4800 0.008 0.006 0.021 0.030 0.034 0.019 0.034 0.033

I 5000 0.008 0.005 0.017 0.026 0.034 0.019 0.034 0.034

Sample Depth, Top OI Btm Side l Side 2 Top Btm Side Side AO Treatment μ OI OI OI TVI TVI 1 TO 2

TVI

2.1.2 1 0 0.035 0.005 0.021 0,016 0.031 0.011 0.039 0.035 Vitamin E

1 200 0.040 0.002 0.018 0,014 0.032 0.011 0.034 0.032

1 400 0.033 -0.005 0.025 0,016 0.032 0.012 0.032 0.030 600 0.030 -0.002 0.019 0,022 0,034 0.011 0.032 0.029

800 0.031 0.003 0.022 0,022 0,034 0.012 0.031 0.031

1000 0.026 0.004 0.027 0.023 0.034 0.012 0.031 0.031

1200 0.013 0.006 0.020 0.015 0.034 0.012 0.031 0.030

1400 0.021 0.010 0.015 0.014 0.034 0.014 0.032 0.031

3600 0.015 0.010 0.011 0.011 0.034 0.014 0.03 3 0.030

3800 0.015 0.009 0.009 0.009 0.034 0.015 0.03 1 0.030

2000 0.012 0.005 0.006 0.009 0.034 0.015 0.03 1 0.030

2200 0.017 0.004 0.010 0.010 0.035 0.015 0.033 0.031

2400 0.024 0.000 0.011 0.008 0.035 0.015 0.030 0.031

2600 0.035 0.001 0.008 0.012 0.035 0.016 0.032 0.031

2800 0.045 0.003 0.009 0.014 0,036 0.036 0.032 0.032

3000 0.055 0.001 0.016 0,014 0,035 0.036 0.033 0.032

3200 0.043 -0.002 0.01 0,021 0,036 0.017 0.034 0.033

3400 0.053 -0.002 0.017 0,026 0,036 0.017 0.034 0.033

3600 0.105 0.002 0.051 0.084 0,038 0.018 0.034 0.034

3800 0.066 -0.001 0.195 0.160 0.037 0.018 0.035 0.036

4000 0.014 0.001 0.284 0.066 0.035 0.019 0.034 0.037

4200 0.008 0.000 0.016 0.010 0.034 0.019 0.034 0.033

4400 0.004 -0.003 0.003 0.005 0.034 0.020 0.034 0.033

4600 0.003 0.000 -0.001 0.005 0.034 0.021 0.034 0.033

4800 0.007 0.001 -0.001 0.000 0.035 0.021 0.034 0.034

5000 0.005 0.003 -0.007 0.001 0.035 0.023 0.034 0.033

Sample Depth, Top Oi Btm Side 1 Side 2 Top Btm Side Side AO Treatment

μ OI OI OI TV! TV! 1 TVl 2

TVl

2.3.3 o 0.019 0.015 0.077 0,069 0,064 0.021 0.044 0.064 VE-Phosphite

200 0.056 0.008 0.065 0,262 0,054 0.019 0.043 0.058

400 0.052 0.011 0.042 0,702 0,053 0.020 0.043 0.049

600 0.042 0.014 0.031 0.540 0,051 0.020 0.042 0.051

800 0.033 0.017 0.015 0.316 0.049 0.020 0.041 0.050

1000 0.021 0.019 0.007 0.123 0.046 0.018 0.041 0.051

3200 0.017 0.018 0.006 0.082 0.043 0.021 0.038 0.048

3400 0.013 0.017 0.004 0.066 0.041 0.018 0.037 0.047

1600 0.013 0.013 0.005 0.069 0.039 0.017 0.045 0.046

1800 0.011 0.009 0.009 0.056 0.038 0.016 0.036 0.044

2000 0.014 0.009 0.012 0.044 0.036 0.015 0.037 0.040

2200 0.012 0.009 0.025 0.053 0.035 0.015 0.036 0.042

2400 0.010 0.011 0.026 0.050 0,035 0.037 0.034 0.039

2600 0.013 0.043 0.026 0,062 0,034 0.036 0.035 0.040

2800 0.012 0.048 0.038 0,082 0,034 0.017 0.039 0.040

3000 0.013 0.041 0.034 0, 107 0,034 0.018 0.036 0.040 3200 0.013 0.037 0.034 0, 121 0,033 0.018 0.037 0.039

3400 0.023 0.056 0.071 0,059 0,034 0.020 0.038 0.036

3600 0.044 0.075 0.129 0,042 0.035 0.021 0.039 0.034

3800 0.074 0.062 0.012 0.028 0.035 0.022 0.038 0.033

4000 0.070 0.008 -0.002 0.031 0.036 0.017 0.037 0.034

4200 0.105 -0.002 0.000 0.026 0.037 0.017 0.035 0.033

4400 0.016 -0.002 0.000 0.019 0.035 0.018 0,035 0.033

4600 0.002 0.001 -0.003 0.021 0.033 0.017 0,036 0.032

4800 0.000 -0.004 0.002 0.024 0.035 0.018 0.036 0.034

5000 -0.001 0.002 0.004 0.023 0.034 0.017 0.035 0.034

Sample Depth, Top OI Btm Side l Side 2 Top Btm Side Side AO Treatment μ OI OI OI TV! TVI 1 TO 2

TVl

2.3.4 o 0.060 0.016 0.026 0,062 0,044 0.027 0.038 0.058 VE-Phosphite-R

200 0.054 0.016 0.033 0,084 0,044 0.025 0.039 0.058

400 0.033 0.014 0.032 0,060 0,044 0.024 0.039 0.058

600 0.033 0.018 0.077 0,045 0.042 0.024 0.039 0.054

800 0.020 0.027 0.150 0.038 0.039 0.024 0.036 0.052

1000 0.017 0.023 0.140 0.027 0.038 0.023 0,036 0.049

3200 0.013 0.023 0. 3 13 0.020 0.037 0.022 0,036 0.047

1400 0.012 0.020 0.045 0.026 0.037 0.020 0,038 0.046

1600 0.013 0.015 0.030 0.038 0.035 0.020 0.038 0.044

1800 0.013 0.010 0.025 0.042 0.035 0.017 0.037 0.042

2000 0.013 0.009 0.016 0.049 0.034 0.017 0.038 0.041

2200 0.015 0.010 0.019 0.037 0.034 0.016 0.036 0.038

2400 0.015 0.008 0.015 0.037 0,034 0.036 0.037 0.039

2600 0.011 0.008 0.025 0,021 0,034 0.016 0.036 0.033

2800 0.016 0.006 0.022 0,017 0,034 0.017 0.037 0.035

3000 0.020 0.008 0.033 0,032 0,034 0.016 0.037 0.037

3200 0.033 0.008 0.071 0,032 0,034 0.016 0.038 0.035

3400 0.068 0.008 0.029 0,058 0.034 0.016 0.038 0.037

3600 0.051 0.015 -0.003 0.096 0.035 0.017 0.035 0.037

3800 0.090 0.052 -0.013 0.308 0.036 0.018 0,037 0.037

4000 0.118 0.065 -0.012 0.021 0.037 0.020 0,035 0.036

4200 0.019 0.060 -0.013 0.011 0.035 0.021 0,036 0.036

4400 0.006 0.075 -0.008 0.010 0.033 0.022 0.035 0.035

4600 0.005 0.018 -0.010 0.007 0.033 0.022 0.036 0.034

4800 0.002 0.000 -0.017 0.011 0.033 0.018 0.035 0.033

5000 0.007 -0.001 -0.014 0.005 0,034 0.038 0.036 0.032

Example 3. [00113] Four sections of a GUR 1050 compression molded bar were treated as follows: Sample 3.1.1 : No coating.

Sample 3.1.2: Coated with a solution of 10% vitamin E (VE) dissolved in isopropanol.

Sample 3.1.3 : Coated with a solution of 10% vitamin E-phosphite (VEP) dissolved in dichloromethane.

Sample 3.1.4: Coated with a solution of 10% recovered vitamin E-phosphite (VEP-R) dissolved in dichloromethane.

[00114] The recovered VEP was obtained by a secondary cleaning of the glassware used for synthesis of the VEP, which had some increased exposure to oxygen during recovery as compared to the VEP which was maintained under an inert environment until application to the UHMWPE section.

[00115] All sections were melted at 150 °C for 14 hours in air, followed by slow cooling

(16 hours) to ambient temperature, in air. Following the initial melting treatment, the sections were heated to 120 °C for 14 hours in air, irradiated warm (120 °C) in air with 75 kGy using a 10 MeV electron beam. After cooling in air, the sections were melted at 150 °C for 14 hours in air, followed by slow cooling (16 hours) to ambient temperature, in air.

[00116] The Samples were sectioned, then films were prepared with a microtome from top to bottom of each sectioned form, and from side to side of each sectioned form, and analyzed for trans-vinyl index and oxidation index per ASTM F2381-10 and ASTM F2102-13, respectively.

[00117] Table 3 illustrates oxidation index to a depth of 5 mm as measured from the top, bottom, and both sides of Samples 3.1.1-3.1.4.

[00118] Table 3. Oxidation index for Samples 3. 1.1-3.1 ,4,

1800 0.1.55 0.163 0,215 0. 139 0,030 0.004 0,028 0,027

2000 0.132 0.143 0, 190 0. 117 0,030 0.005 0,029 0,027

2200 0.126 0.135 0.185 0.102 0.030 ' 0.004 0.029 0,026

2400 0.121 0.134 0.170 0.097 0.030 0.005 0.030 0.028

2600 0.105 0.124 0.158 0.087 0.031 0.005 0.029 0.029

2800 0, 111 0.1 15 0.151 0.082 0.031 0,007 0.030 0.030

3000 0,099 0.106 0.140 0.073 0.028 0,003 0.030 0.029

3200 0, 104 0.103 0.132 0.066 0.032 0,006 0.032 0.030

3400 0.095 0.099 0.123 0.059 0.031 0.006 0.031 0.030

3600 0.088 0.085 0.125 0.043 0.032 0.007 ' 0.031 0.030

3800 0.087 0.083 0.118 0.043 0.032 0.009 0.032 0.031

4000 0.076 0.074 0.122 0.035 0.032 0.008 0.032 0.031

4200 0.068 0.073 0, 106 0.020 0,032 0.008 0,032 0,031

4400 0.063 0.072 0,098 0.022 0,032 0.006 0,033 0,032

4600 0.051 0.069 0,096 0.017 0,032 0.009 0,032 0.031

4800 0.047 0.069 0.087 0.014 0.032 ' δ.δϊϊ 0.032 0.032

5000 0.047 0.062 0.091 0.005 0.033 ' 0.009 0.034 0.032

Sample Depth, μ Top OI Btm Side 1 Side 2 Top Btm Side 1 Side 2 AO

OI OI OI TVI TVI TVI TVI Treatment

3.1.2 0 5.981 0.760 3.147 2.090 0.046 0,009 0.085 0.020 Vitamin E

200 1.817 0.024 4.505 0.201 0.021 0,007 0.030 0.028

400 0.316 0.023 0.633 0.086 0.032 0.004 ^' 0.031 0.028

600 0.126 0.026 0.174 0.058 0.034 0.007 ' 0.039 0.030

800 0.065 0.029 0.129 0.058 0.034 0.005 0.036 0.028

1000 0.050 0.024 0, 116 0.031 0,032 0.006 0,036 0,027

1200 0.048 0.026 0.078 0.044 0,033 0.006 0,034 0,028

1400 0.039 0.024 0.073 0.035 0,033 0.006 0,035 0,029

1600 0.037 0.014 0,059 0.032 0,033 0.005 0,034 0,036

1800 0.025 0.013 0.053 0.031 0.033 ' 0.007 0.033 0.030

2000 0.033 0.017 0.050 0.029 0.031 ' 0.008 0.035 0.030

2200 0.018 0.019 0.041 0.032 0.034 0.007 0.034 0.032

2400 0,015 0.014 0.043 0.029 0.033 0,008 0.034 0.032

2600 0,016 0.019 0.039 0.026 0.035 0,007 0.032 0.031

2800 0,004 0.015 0.033 0.022 0.032 0,008 0.033 0.031

3000 0,006 0.024 0.032 0.020 0.032 0,009 0.033 0.032

3200 0.012 -0.002 0.031 0.021 0.033 0.009 ' 0.032 0.031

3400 0.013 0.019 0.024 0.017 0.034 0.012 ' 0.032 0.032

3600 0.013 0.007 0.025 0.020 0.033 0.010 0.032 0.032

3800 0.016 0.018 0,025 0.019 0,033 0.01 1 0,032 0,033

4000 0.008 0.019 0,023 0.018 0,033 0.021 0,032 0,033

4200 0.000 0.026 0,022 0.022 0,033 0.011 0,032 0,033

4400 0.009 0.024 0.026 0.023 0,036 0.012 0,032 0,033 4600 0.009 0.023 0,026 0.018 0,034 0.012 0,035 0,033

4800 0.007 0.017 0,034 0.025 0,033 0.013 0.032 0,034

5000 0.017 0.017 0.055 0.022 0.033 ' 0.012 0.033 0,033

Sample Depth, μ Top OI Btm Side 1 Side 2 Top Btm Side 1 Side 2 AO

OI OI OI TVl TVI TVI TVI Treatment

3.1.3 0 0,044 6.389 30, 174 -0.039 0.032 0,048 0.052 0.029 VE-

200 0.035 4.050 3.421 -0.024 0.033 0,044 0.038 0.028 Phosphite

400 0.030 1.381 1.282 -0.025 0.032 0,030 ' 0.044 0.028

600 0.023 0.618 0.700 -0.017 0.032 0.02Ϊ ' 0.045 0.029

800 0.021 0.346 0.907 -0.005 0.035 0.015 0.046 0.030

1000 0.022 0.275 0.736 0.011 0.033 0.014 0.046 0.029

1200 0.018 0.259 0,440 2.696 0,033 0.014 0,043 0,037

1400 0.017 0.262 0,324 1.661 0,033 0.014 0,041 0,043

1600 0.020 0.288 0,267 0.393 0,032 0.015 0,040 0,035

1800 0.019 0.299 0.221 0.211 0,033 ' 6.6 Ϊ6 0.039 0,032

2000 0.023 0.295 0.228 0.210 0,033 ' 6.6 Ϊ6 0.037 0,032

2200 0.023 0.259 0.238 0.122 0.032 0.015 0.038 0.031

2400 0.037 0.187 0.255 0.172 0.032 0.013 0.036 0.033

2600 0,040 0.156 0.219 0.01.1 0.032 0,011 0.036 0.030

2800 0.126 0.134 0.255 -0.030 0.032 0,011 0.034 0.029

3000 1.000 0.1 18 0.256 -0.035 0.035 0,010 0.034 0.029

3200 0.402 0.114 0.241 -0.044 0.036 0.0 i 1 ^' 0.033 0.029

3400 0.238 0.102 0.246 -0.040 0.036 o.oio ' 0.032 0.029

3600 0.060 0.096 0.232 -0.046 0.034 0.0 i i 0.032 0.030

3800 0.042 0.095 0.244 -0.045 0,035 0.01 1 0,03 3 0,031

4000 0.027 0.087 0,237 -0.044 0,035 0.012 0,03 3 0,031

4200 0.017 0.087 0,222 -0.045 0,034 0.011 0,03 1 0,032

4400 0.010 0.078 0,250 -0.041 0,034 0.011 0,03 1 0,032

4600 0.005 0.069 0.241 -0.039 0,034 ' 6.6 Ϊ3 0.030 0,031

4800 0.005 0.073 0.230 -0.044 0,034 ' 6.6ΓΪ 0.030 0,031

5000 0.000 0.061 0.200 -0.042 0.034 0.012 0.031 0.032

Sample Depth, μ Top OI Btm Side 1 Side 2 Top Btm Side 1 Side 2 AO

OI OI OI TVI TVI TVI TVI Treatment

3.1.4 0 0.079 0.078 0.091 0.059 0.047 0.015 0.032 0.055 VE-

200 0.057 0.067 0.053 0.060 0.035 6.015 ' 0.030 0.053 Phospiiite-R

400 0.049 0.060 0.051 0.055 0.034 0.0 i 6 0.030 0.051

600 0.051 0.053 0.047 0.049 0.034 0.016 0.032 0.049

800 0.052 0.050 0,044 0.050 0,035 0.015 0,03 3 0,048

1000 0.048 0.046 0,040 0.048 0,036 0.014 0,032 0,045

1200 0.047 0.045 0,046 0.046 0,035 0.014 0,032 0,043

1400 0.045 0.049 0.043 0.047 0,034 ' 6.6 Ϊ3 0.032 0,042

1600 0.044 0.059 0.039 0.064 0,034 ' 6.6 Ϊ3 0.032 0,042 1800 0.044 0.204 0,042 0.3 14 0,036 0.017 0.033 0,041

2000 0.039 1.610 0,052 0.389 0,036 0.046 0,034 0.041

2200 0.037 0.572 0.079 0.411 0,034 ' 6.031 0.034 0.039

2400 0.041 0.341 0.665 0.240 0.034 6.023 0.039 0.037

2600 0.045 0.306 0.410 0.207 0.034 0.026 0.036 0.037

2800 0,041 0.229 0.258 0.289 0.035 0,019 0.035 0.039

3000 0,046 0.065 0.286 0.142 0.036 0,012 0.036 0.037

3200 0,043 0.032 0.202 0.052 0.033 0,009 0.037 0.035

3400 0.047 0.018 0.041 0.037 0.035 0,010 0.034 0.035

3600 0.569 0.023 0.027 0.035 0.037 0.009 ' 0.034 0.036

3800 0.461 0.018 0.041 0.029 0.038 0.009 0.035 0.035

4000 0.097 0.021 0.085 0.033 0.034 0.009 0.033 0.035

4200 0.030 0.020 0,068 0.084 0,033 0.009 0.035 0,034

4400 0.022 0.038 0,082 0.355 0,037 0.011 0.038 0,034

4600 0.031 0.011 0,03 1 0.094 0,037 0.011 0,037 0,035

4800 0.138 0.015 0.010 0.033 0,035 ' ο.οϊϊ 0.036 0,035

5000 0.075 0.015 0.004 0.016 0,035 ' ο.οϊϊ 0.036 0,036

Example 4.

Four sections of a GUR 1050 compression molded bar were treated as follows: Sample 4.1.1 : No coating.

Sample 4.1.2: Coated with a solution of 10% vitamin E (VE) dissolved in isopropanol.

Sample 4.1.3 : Coated with a solution of 10% vitamin E-phosphite (VEP) dissolved in dichloromethane.

Sample 4.1.4: Coated with a solution of 10% recovered vitamin E-phosphite (VEP-R) dissolved in dichloromethane.

[00120] The recovered VEP was obtained by a secondary cleaning of the glassware used for synthesis of the VEP, which had some increased exposure to oxygen during recovery as compared to the VEP which was maintained under an inert environment until application to the UHMWPE section.

[00121] All sections were individually placed in a metallized mylar bag under nitrogen purge to prevent oxygen infiltration. The bagged sections were then melted at 150 °C for 14 hours in air, followed by slow cooling (16 hours) to ambient temperature. Following the initial melting treatment, the bagged sections were heated to 120 °C for 14 hours, irradiated warm (120 °C) with 75 kGy using a 10 MeV electron beam. After cooling in the mylar bags purged with nitrogen, the sections were removed from the inert atmosphere and were melted at 150 °C for 14 hours in air, followed by slow cooling (16 hours) to ambient temperature, in air.

[00122] The Samples were sectioned, then films were prepared with a microtome from top to bottom of each sectioned form, and from side to side of each sectioned form, and analyzed for trans-vinyl index and oxidation index per ASTM F2381-10 and ASTM F2102-13, respectively.

[00123] Table 4 illustrates oxidation index to a depth of 5 mm as measured from the top, bottom, and both sides of Samples 4.1.1-4.1.4.

00124] Table 4. Oxidation index for Samples 4. 1.1-4.1 ,4.

4.1.2 0 -0.017 0.043 0.006 -0.080 0.028 0.003 0.030 0,03 ! Vitaniiti E

200 -0.030 0.034 0.018 -0.079 0.035 0.004 0.025 0,033

400 -0.029 0.031 0.025 -0.075 0.036 0.004 0.028 0.033

600 -0.028 0.035 0.016 -0.077 0.032 0.005 0.027 0.032

800 -0.034 0.030 0.017 -0.070 0.030 0.005 0,029 0.031

1000 -0.016 0.021 -0.006 -0.062 0.034 0.004 0,025 0.033

1200 -0.028 0.033 -0.010 -0.065 0.033 0.005 0,025 0.032

1400 -0.019 0.027 -0.025 -0.062 0.034 0.005 0,027 0.034

1600 -0.040 0.021 -0.031 -0.059 0.031 0.006 0,027 0.032

1800 -0.052 0.021 -0.023 -0.046 0.031 0.006 0.027 0.032

2000 -0.063 0.017 -0.027 -0.055 0.032 0.005 0.026 0.032

2200 -0.051 0.023 -0.038 -0.045 0.03 3 0.006 0.026 0,032

2400 -0.043 0.01.9 -0,027 -0.054 0.034 0.006 0.028 0,032

2600 -0.037 0.021 -0,022 -0.070 0.037 0.006 0.028 0,032

2800 -0.047 0.022 -0,024 -0.065 0.034 0.008 0.028 0,032

3000 -0.028 0.021 -0.034 -0.068 0.035 0.007 0.032 0,033

3200 -0.025 0.022 -0.039 -0.059 0.033 0.007 0.030 0.032

3400 -0.032 0.019 -0.038 -0.078 0.034 0.008 0.029 0.032

3600 -0.032 0.027 -0.037 -0.062 0.033 0.008 0,029 0.032

3800 -0.033 0.025 -0.023 -0.045 0.036 0.008 0,028 0.033

4000 -0.053 0.021 -0.027 -0.069 0.034 0.008 0,029 0.031

4200 -0.042 0.021 -0.036 -0.051 0.034 0.009 0,030 0.031

4400 -0.051 0.023 -0.026 -0.079 0.036 0.010 0,030 0.031

4600 -0.039 0.020 -0.037 -0.082 0.035 0.010 0.030 0.032

4800 -0.034 0.018 -0.024 -0.087 0.035 0.010 0.030 0.031

5000 -0.032 0.020 -0.034 -0.087 0.035 0.030 0.028 0,032

Sample Depth, Top BtilB Side 1 Side 2 Top BtilB Side 1 Side 2 AO

μ OI OI OI OI TVI TVI TVI TVI Treatment

4.1.3 o 0.013 -0.039 0.058 -0.002 0.037 0.019 0.031 0,039 VE-

200 0.004 -0.047 0.042 -0.010 0.037 0.020 0.029 0.030 Phosphite

400 0.002 -0.029 0.047 -0.005 0.036 0.020 0,030 0.031

600 0,009 -0.004 0.041 0,001 0.040 0.022 0,030 0.032

800 0,011 0.010 0.042 0,001 0.036 0.021 0,029 0.030

1000 0,008 0.010 0.039 -0.001 0.035 0.021 0,029 0.031

1200 0,004 0.010 0.035 0,006 0.037 0.019 0,030 0.031

1400 0.009 0.006 0.030 0.007 0.036 0.018 0,030 0.031

1600 0.002 0.006 0.027 0.008 0.036 0.017 0.033 0.031

1800 0.005 0.000 0.026 0.007 0.036 0.035 0.032 0,030

2000 0.004 -0.002 0.025 0.009 0.035 0.034 0.031 0,030

2200 -0.003 -0.003 0.022 0.01 1 0.035 0.013 0.032 0,03 !

2400 0.000 -0.008 0.023 0.014 0.035 0.012 0.032 0,03 !

2600 -0.001 0.004 0.03 1 0.011 0.035 0.014 0.033 0,030

Example 5. [00125] Four sections of a GUR 1050 compression molded bar were treated as follows: Sample 5.1.1 : No coating.

Sample 5.1.2: Coated with a solution of 10% vitamin E (VE) dissolved in isopropanol.

Sample 5.1.3 : Coated with a solution of 10% vitamin E-phosphite (VEP) dissolved in dichloromethane.

Sample 5.1.4: Coated with a solution of 10% recovered vitamin E-phosphite (VEP-R) dissolved in dichloromethane.

[00126] The recovered VEP was obtained by a secondary cleaning of the glassware used for synthesis of the VEP, which had some increased exposure to oxygen during recovery as compared to the VEP which was maintained under an inert environment until application to the UHMWPE section.

[00127] All sections were melted at 150 °C for 14 hours in air, followed by slow cooling

(16 hours) to ambient temperature, in air. Following the initial melting treatment, the sections were irradiated in air with 100 kGy using a 10 MeV electron beam. After cooling in air, the sections were melted at 150 °C for 14 hours in air, followed by slow cooling ( 16 hours) to ambient temperature, in air.

[00128] The Samples were sectioned, then films were prepared with a microtome from top to bottom of each sectioned form, and from side to side of each sectioned form, and analyzed for trans-vinyl index and oxidation index per ASTM F2381-10 and ASTM F2102-13, respectively.

[00129] Table 5 illustrates oxidation index to a depth of 5 mm as measured from the top, bottom, and both sides of Samples 5.1.1-5.1.4.

[00130] Table 5. Oxidation index for Samples 5. 1.1-5.1 ,4.

Sample Depth, Top Btm Side 1 Side 2 Top Btm Side Side 2 TV! AO Treatment

μ OI OI OI OI TVI TVI 1

TVI

5.1.1 o 8.399 4.524 9.204 7.441 0,047 0.043 0.047 0.049 None

200 3.758 2.601 3.853 5.347 0.032 0.034 0.035 0.040

400 1.027 1.207 1.090 1.632 0.033 0.035 0.035 0.042

600 0,512 0.624 0.547 0,789 0.034 0.037 0,036 0.046

800 0.313 0.363 0.331 0,496 0.034 0.036 0,036 0.046

1000 0.318 0.236 0.331 0,293 0.037 0.036 0,036 0.046

1200 0.276 0.172 0.303 0,245 0.036 0.038 0.036 0.045

1400 0.181 0.137 0.218 0,202 0.036 0.037 0.037 0.045 1600 0.151 0.119 0.186 0.190 0,035 0.038 0.035 0,044

1800 0.137 0.103 0.162 0.178 0,036 0.038 0.034 0,043

2000 0.124 0.084 0.142 0.165 0.036 0.037 0.035 0.043

2200 0.112 0.074 0.123 0.152 0.036 0.038 0.034 0.042

2400 0.114 0.063 0.11 1 0.141 0.036 0.038 0.033 0.041

2600 0,092 0.055 0.118 0, 146 0.036 0.040 0,033 0.040

2800 0,087 0.039 0.110 0, 133 0.035 0.039 0,032 0.040

3000 0,077 0.037 0.105 0, 126 0.036 0.038 0.033 0.039

3200 0.079 0.029 0.097 0.109 0.036 0.038 0.032 0.038

3400 0.052 0.021 0.091 0.113 0.036 0.038 0.033 0.038

3600 0.063 0.009 0.092 0.097 0,035 0.038 0.032 0,038

3800 0.064 -0.004 0.088 0.089 0,037 0.039 0.033 0,037

4000 0.052 -0.001 0.079 0.087 0,036 0.040 0.032 0,037

4200 0.055 -0.030 0.072 0.079 0,035 0.039 0.033 0,037

4400 0.053 -0.010 0.066 0.075 0,036 0.040 0.033 0,037

4600 0.046 -0.004 0.062 0.075 0.037 0.039 0.033 0.036

4800 0.043 -0.002 0.062 0.075 0.037 0.040 0.032 0.036

5000 0.042 -0.010 0.060 0,071 0.036 0.040 0.033 0.036

Sample Depth, Top Btm SMe l Side 2 Top Btm Side Side 2 TVI AO Treatment μ OI OI OI OI TVI TVI 1

TVI

5.1.2 0 8.242 3.529 4.698 7, 104 0.053 0.080 0.030 0.053 Vitamin F.

200 1.660 3.127 0.694 2.071 0.025 0.027 0.032 0.023

400 0.370 0.521 0.235 0.402 0.035 0.031 0.041 0.033

600 0.204 0.230 0.179 0.212 0,035 0.036 0.036 0,037

800 0.166 0.150 0.162 0.128 0,036 0.038 0.051 0,037

1000 0.136 0.121 0.167 0.120 0,036 0.038 0.036 0,038

1200 0.119 0.108 0.161 0.102 0,036 0.038 0.036 0,042

1400 0.106 0.095 0.121 0.079 0,036 0.039 0.036 0,037

1600 0.095 0.088 0.103 0.075 0.037 0.038 0.035 0.037

1800 0.087 0.071 0.108 0.069 0.070 0.037 0.036 0.038

2000 0.075 0.066 0.106 0,060 0.037 0.038 0.037 0.037

2200 0.071 0.062 0.090 0,055 0.036 0.037 0,037 0.039

2400 0,060 0.054 0.078 0,048 0.037 0.037 0,036 0.038

2600 0,054 0.048 0.077 0,043 0.037 0.038 0.036 0.038

2800 0,046 0.038 0.070 0,037 0.036 0.037 0.036 0.038

3000 0.041 0.033 0.068 0.030 0.037 0.041 0.036 0.038

3200 0.040 0.027 0.066 0.018 0.038 0.038 0.038 0.038

3400 0.041 0.019 0.065 0.019 0,037 0.038 0.035 0,038

3600 0.038 0.014 0.068 0.016 0,038 0.038 0.037 0,039

3800 0.040 0.009 0.073 0.012 0,038 0.038 0.037 0,039

4000 0.043 0.008 0.065 0.007 0,038 0.040 0.039 0,040 4200 0.051 0.011 0.069 0.003 0,037 0.038 0.037 0,038

4400 0.055 0.011 0.073 0.004 0,037 0.037 0.038 0,038

4600 0.047 0.000 0.065 0.003 0,038 0.039 0.038 0,038

4800 0.045 -0.009 0.062 0.000 0.038 0.039 0.038 0.038

5000 0.042 0.006 0.058 -0.004 0.038 0.039 0.038 0.038

Sample Depth, Top Btm Side 1 Side 2 Top Btm Side Side 2 TVI AO Treatment μ OI OI OI OI TVI TVI 1

TVI

5.1.3 0 5.334 -0.009 0.175 -0.015 0.047 0.031 0.067 0.043 VE-Phosphite

200 2.343 -0.013 0.037 -0.019 0.032 0.031 0.054 0.045

400 0.752 -0.013 0.027 -0.016 0.041 0.030 0.054 0.043

600 0.493 -0.018 0.024 -0.020 0.043 0.029 0.053 0.036

800 0.385 -0.033 0.01 3 -0.019 0,044 0.029 0.051 0,036

1000 0.392 -0.021 0.005 -0.024 0,044 0.029 0.047 0,034

1200 0.477 -0.024 0.012 -0.024 0,043 0.033 0.048 0,033

1400 0.550 -0.025 0.006 -0.033 0,049 0.031 0.050 0,035

1600 0.433 -0.030 0.016 -0.037 0,044 0.029 0.047 0,034

1800 0.248 -0.024 0.015 -0.010 0.042 0.032 0.047 0.035

2000 0.221 -0.029 0.032 -0.003 0.042 0.032 0.048 0.034

2200 0, 192 -0.035 0.042 -0.001 0.042 0.032 0,048 0.036

2400 0.249 -0.030 0.540 0, 167 0.044 0.032 0.048 0.033

2600 0,098 -0.041 0.499 0,325 0.043 0.034 0.046 0.035

2800 0.029 -0.033 0.233 0,291 0.043 0.032 0.046 0.036

3000 0.030 -0.036 0.217 0, 160 0.046 0.030 0.045 0.036

3200 0.025 -0.034 0.290 0.011 0.042 0.032 0.048 0.033

3400 0.025 -0.035 0.064 -0.001 0.042 0.031 0.044 0.034

3600 0.028 -0.041 0.415 -0.015 0,041 0.031 0.039 0,032

3800 0.045 -0.033 0.127 -0.0 8 0,042 0.030 0.039 0.031

4000 0.021 -0.034 0.072 0.036 0,043 0.032 0.041 0,032

4200 0.021 -0.043 0.073 0.093 0,043 0.033 0.042 0,033

4400 0.019 -0.041 0.053 0.023 0,043 0.032 0.041 0,034

4600 0.027 -0.035 0.004 -0.025 0.043 0.032 0.040 0.032

4800 0,015 -0.034 -0.009 -0.029 0.040 0.031 0,043 0.033

5000 0,018 -0.034 -0.010 -0.034 0.044 0.030 0,040 0.032

Sample Depth, Top Btm Side 1 Side 2 Top Btm Side Side 2 TVI AO Treatment μ OI OI OI OI TVI TVI 1

TVI

5.1.4 0 0.053 -0.026 0.147 0.065 0.040 0.028 0.062 0.051 VE-Phosphite-R

200 0.041 -0.054 0.002 0.008 0.036 0.023 0.047 0.049

400 0.034 -0.043 0.002 0.000 0,036 0.024 0.047 0,047

600 0.017 -0.033 -0,005 -0.017 0,037 0.027 0.046 0,046

800 0.016 -0.031 -0,022 -0.029 0,036 0.028 0.044 0,045

1000 0.021 -0.030 -0,027 -0.035 0,037 0.027 0.043 0,044 1200 0.017 -0.032 -0,026 -0.040 0,037 0.028 0.042 0,042

1400 0.013 -0.033 -0,029 -0.041 0,037 0.027 0.041 0,042

1600 0.023 -0.035 -0.035 -0.041 0,040 0.030 0.041 0,042

1800 0.022 -0.043 -0.034 -0.037 0.038 0.027 0.038 0.041

2000 0.147 -0.042 -0.025 -0.025 0.039 0.027 0.039 0.041

2200 0,539 -0.038 -0.023 -0.025 0.042 0.028 0.039 0.041

2400 0,345 -0.042 -0.020 -0.020 0.041 0.028 0.037 0.042

2600 0,460 -0.037 -0.003 0,066 0.043 0.028 0,038 0.041

2800 0.296 -0.047 0.117 1,216 0.043 0.028 0.038 0.037

3000 0.059 -0.045 0.430 0,398 0.038 0.028 0.037 0.039

3200 0.005 -0.036 0.298 0.285 0.037 0.029 0.037 0.041

3400 -0.001 -0.043 0.295 0.126 0.037 0.028 0.040 0.041

3600 0.000 -0.044 0.023 -0.001 0,037 0.029 0.035 0,038

3800 0.001 -0.048 -0,020 -0.010 0,038 0.027 0.034 0,037

4000 0.072 -0.041 -0,008 -0.004 0,037 0.030 0.033 0,038

4200 0.209 -0.049 0.056 -0.011 0,035 0.033 0.031 0,037

4400 0.037 -0.043 0.077 -0.034 0,039 0.029 0.032 0,036

4600 -0.001 -0.046 0.023 -0.046 0.038 0.029 0.034 0.035

4800 -0.007 -0.070 -0.028 -0.049 0.038 0.032 0.033 0.034

5000 -0.009 -0.047 -0.044 -0.052 0.037 0.029 0.032 0.034

Example 6.

isopropanol.

Sample 6.1.3 : Coated with a solution of 10% vitamin E-phosphite (VEP) dissolved in dichloromethane.

Sample 6.1.4: Coated with a solution of 10% recovered vitamin E-phosphite (VEP-R) dissolved in dichloromethane.

[00132] The recovered VEP was obtained by a secondary cleaning of the glassware used for synthesis of the VEP, which had some increased exposure to oxygen during recovery as compared to the VEP which was maintained under an inert environment until application to the UHMWPE section.

[00133] All sections were individually placed in a metallized mylar bag under nitrogen purge to prevent oxygen infiltration. The bagged sections were then melted at 150 °C for 14 hours in air, followed by slow cooling (16 hours) to ambient temperature. Following the initial melting treatment, the bagged sections were irradiated with 100 kGy using a 10 MeV electron beam. After cooling in the mylar bags purged with nitrogen, the sections were removed from the inert atmosphere and were melted at 150 °C for 14 hours in air, followed by slow cooling (16 hours) to ambient temperature, in air.

[00134] The Samples were sectioned, then films were prepared with a microtome from top to bottom of each sectioned form, and from side to side of each sectioned form, and analyzed for trans-vinyl index and oxidation index per ASTM F2381-10 and ASTM F2102-13, respectively.

[00135] Table 6 illustrates oxidation index to a depth of 5 mm as measured from the top, bottom, and both sides of Samples 6.1.1-6.1.4.

[00136] Table 6. Oxidation index for Samples 6.1.1 -6.1.4.

4800 0,021 -0,004 -0.003 -0.015 0.039 0,040 0.039 0.034

5000 0,016 -0,008 -0.004 -0.009 0.038 0.040 0.039 0.035

Sample Depth, Top Btm Side 1 Side 2 Top Btm Side Side 2 TVI AO

μ OI OI OI OI TVI TVI 1 Treatment

TVI

6.1.2 0 1 1,339 3.188 0.039 0,067 0.061 0.11 1 0,041 0.057 Vitamin E

200 6.656 1.836 0,038 0,059 0.065 0.045 0,042 0.054

400 4.394 0.275 0,014 0,044 0.033 0.042 0,040 0.052

600 0.711 0.162 0.004 0,030 0.031 0.042 0,039 0.050

800 0.279 0.128 -0.006 0,019 0.038 0.042 0,038 0.048

1000 0.189 0.103 -0.010 0.012 0.039 0.043 0.036 0.048

1200 0.158 0.077 -0.013 0.006 0.039 0.041 0.036 0.046

1400 0, 120 0.061 -0,015 0.010 0.039 0,042 0.035 0.046

1600 0, 104 0.052 -0,022 0.004 0.038 0,043 0.034 0.044

1800 0,090 0.044 -0.017 0.004 0.039 0.042 0.034 0.043

2000 0.077 0.018 -0.019 0.004 0.038 0.041 0.034 0.044

2200 0.072 0.023 -0.041 0.002 0.039 0.040 0.033 0.044

2400 0.067 0.024 -0.022 0.002 0.037 0.041 0.034 0.042

2600 0.058 0.017 -0.022 0.001 0.038 0.041 0.033 0.042

2800 0.054 0.032 -0.019 0,008 0.038 0.042 0,032 0.042

3000 0.047 0.011 -0.017 0,014 0.037 0.042 0,032 0.041

3200 0.048 0.007 -0.020 0,041 0.038 0.041 0,032 0.041

3400 0.034 0.004 -0.019 0,091 0.037 0.041 0,032 0.039

3600 0.034 0.000 -0.014 0, 101 0.037 0.041 0,032 0.039

3800 0.033 -0.002 -0.005 0.086 0.038 0.041 0.032 0.041

4000 0.016 -0.009 0.047 0.086 0.038 0.042 0.031 0.042

4200 0,027 -0,005 0.057 0.028 0.038 0,042 0.032 0.041

4400 0,002 -0,009 0.095 0.011 0.040 0.042 0.034 0.041

4600 0,016 -0,010 -0.008 0.003 0.038 0.042 0.033 0.039

4800 0.007 -0,014 -0.023 -0.008 0.037 0.043 0.031 0.039

5000 -0.001 -0,009 -0.032 -0.004 0.039 0.043 0.032 0.038

Sample Depth, Top Btm Side 1 Side 2 Top Btm Side Side 2 TO AO

μ OI OI OI OI TVI TVI 1 Treatment

TVI

6.1.3 0 0.066 0.029 2,329 2,905 0.044 0.040 0, 146 0.028 VE-Phosphite

200 0.046 0.010 5,314 0,510 0.034 0.032 0,037 0.040

400 0.046 0.041 0,911 0,261 0.038 0.038 0,034 0.049

600 0.036 0.030 0.274 0.148 0.036 0.039 0.044 0.051

800 0.028 0.026 0.159 0.128 0.038 0.040 0.044 0.050

1000 0,033 0.023 0. 3 13 0.1 10 0.038 0.038 0.044 0.050

1200 0,032 0.021 0.098 0.095 0.036 0,040 0.043 0.049

1400 0,027 0.016 0.081 0.078 0.037 0.038 0.043 0.048

1600 0,027 0.011 0.074 0.072 0.036 0.038 0.044 0.048 1800 0,025 0.012 0.058 0.067 0.036 0.038 0.042 0.048

2000 0,023 0.010 0.057 0.056 0.035 0.043 0.042 0.047

2200 0,020 0.018 0.042 0.043 0.037 0.040 0.041 0.047

2400 0.018 0.021 0.034 0.021 0.037 0.040 0.040 0.046

2600 0.018 0.052 0.031 0.029 0.037 0.039 0.041 0.047

2800 0.01 1 0.056 0,026 0,029 0.038 0.041 0,040 0.046

3000 0.012 0.051 0,018 0,017 0.038 0.042 0,040 0.045

3200 0.014 0.037 0,034 0,017 0.037 0.044 0,040 0.044

3400 0.019 0.101 0.009 0,009 0.038 0.043 0,039 0.045

3600 0.038 0.040 0.012 0,005 0.038 0.043 0,038 0.044

3800 0,076 0.009 0.011 0.005 0.036 0.043 0.039 0.045

4000 0,066 -0.001 0.007 -0.002 0.039 0.040 0.039 0.045

4200 0, 101 -0,006 0.015 0.001 0.038 0,042 0.038 0.044

4400 0,054 -0,006 0.014 -0.007 0.040 0,040 0.039 0.044

4600 0,016 -0,015 0.016 -0.004 0.039 0.043 0.038 0.044

4800 0,012 -0.012 0.008 -0.008 0.040 0.042 0.039 0.044

5000 0.007 -0.011 -0.002 -0.009 0.039 0.041 0.038 0.043

Sample Depth, Top Btm Side 1 Side 2 Top Btra Side Side 2 TO AO

μ OI OI OI OI TVI TVI 1 Treatment

TVI

6.1.4 0 0.3 14 0.023 0,087 0,029 0.043 0.036 0,057 0.053 VE-

200 0.098 0.051 0,042 0,021 0.035 0.036 0,049 0.048 Phospihite-R

400 0.064 0.045 0.035 0,004 0.037 0.038 0,048 0.046

600 0.050 0.037 0.024 -0.003 0.038 0.036 0,048 0.045

800 0.045 0.036 0.017 -0.013 0.037 0.036 0.049 0.047

1000 0.044 0.035 0.002 -0.032 0.036 0.038 0.048 0.043

1200 0,031 0.024 -0.003 -0.015 0.036 0.037 0.046 0.044

1400 0,031 0.025 0.008 -0.029 0.036 0.037 0.046 0.044

1600 0,030 0.023 -0.003 -0.027 0.036 0.037 0.044 0.043

1800 0,028 0.023 0.003 -0.023 0.036 0.037 0.045 0.041

2000 0,023 0.018 -0.006 -0.021 0.036 0.038 0.044 0.042

2200 0.027 0.012 -0.010 -0.027 0.035 0.038 0.044 0.041

2400 0.023 0.033 -0.012 -0.022 0.034 0.048 0,042 0.040

2600 0.021 0.035 -0.012 -0.023 0.036 0.039 0,042 0.042

2800 0.017 0.034 -0.015 -0.039 0.038 0.040 0,042 0.040

3000 0.018 0.036 -0.010 -0.023 0.038 0.038 0,042 0.040

3200 0.019 0.013 -0.012 -0.017 0.037 0.039 0,041 0.039

3400 0.018 0.028 -0.009 -0.016 0.037 0.040 0,041 0.039

3600 0,016 0.105 -0.008 -0.016 0.038 0.038 0.041 0.039

3800 0,012 0.319 -0,012 -0.014 0.038 0,036 0.041 0.039

4000 0,015 0.218 -0,013 -0.010 0.038 0,042 0.041 0.039

4200 0,009 0.036 -0.013 0.001 0.039 0.042 0.041 0.039 4400 0,019 0.001 -0,023 0.317 0.040 0,040 1 0.039 0.035

4600 0,027 -0,003 -0.020 0.328 0.038 0,039 1 0.040 0.038

4800 0, 188 -0.007 -0.012 0.027 0.035 0.040 1 0.041 0.040

5000 0.201 -0.009 -0.01 1 0.000 0.038 0.040 0.041 0.040

[00137] Table 7 illustrates average oxidation index and average trans vinyl index, along with standard deviations, for all of the samples in Examples 1-6.

[00138] Table 7. Average oxidation index and average trans vinyl index for Example 1-6, where "TB" indicates top to bottom, and where "SS" indicates side to side.

The terms and expressions that have been employed are used as terms of description and not of limitation, and there is no intention in the use of such terms and expressions of excluding any equivalents of the features shown and described or portions thereof, but it is recognized that various modifications are possible within the scope of the embodiments of the present invention. Thus, it should be understood that although the present invention has been specifically disclosed by specific embodiments and optional features, modification and variation of the concepts herein disclosed may be resorted to by those of ordinary skill in the art, and that such modifications and variations are considered to be within the scope of embodiments of the present invention. Ad diti onal Emb odiments .

[00140] The following exemplary embodiments are provided, the numbering of which is not to be construed as designating levels of importance:

[00141] Embodiment 1 provides a method of melt-stabilizing ultra high molecular weight polyethylene (UHMWPE), the method comprising:

coating a solid material comprising UHMWPE with an antioxidant, to provide an antioxidant-coated solid material;

pre-irradiatively heating the antioxidant-coated solid material to diffuse the antioxidant therein, to provide an antioxidant-diffused solid material;

irradiating the antioxidant-diffused solid material, to provide an irradiated solid material; post-i rradiatively heating the irradiated solid material, the heating sufficient to melt at least part of the UHMWPE, to provide a heated material; and

solidifying the heated material, to provide a melt-stabilized material.

[00142] Embodiment 2 provides the method of Embodiment 1, wherein about 1 wt% to about 100 wt% of the solid material comprising the UHMWPE is the UHMWPE,

[00143] Embodiment 3 provides the method of any one of Embodiments 1-2, wherein the solid material comprising the UHMWPE is a monolith.

[00144] Embodiment 4 provides the method of any one of Embodiments 1-3, wherein about 90 wt% to about 100 wt¾ of the solid material comprising the UHMWPE is the

UHMWPE,

[00145] Embodiment 5 provides the method of any one of Embodiments 1-4, wherein coating the solid material with the antioxidant comprises coating the solid material with a liquid composition comprising the antioxidant, wherein about 1 wt% to about 100 wt% of the liquid composition is the antioxidant.

[00146] Embodiment 6 provides the method of any one of Embodiments 1-5, wherein coating the solid material with the antioxidant includes coating about 1% to about 100% of a surface of the solid material.

[00147] Embodiment 7 provides the method of any one of Embodiments 1-6, wherein coating the solid material with the antioxidant includes coating about 90% to about 100% of a surface of the solid material. [00148] Embodiment 8 provides the method of any one of Embodiments 1-7, wherein the coating is sufficient to contact at least some of the UHMWPE and the antioxidant.

[00149] Embodiment 9 provides the method of any one of Embodiments 1-8, wherein the coating is sufficient to penetrate a surface layer of the solid material.

[00150] Embodiment 10 provides the method of Embodiment 9, wherein the surface layer of the solid material comprises a layer of about 1 mm deep.

[00151] Embodiment 1 provides the method of any one of Embodiments 9-10, wherein the surface layer of the solid material comprises a layer of about 1 mm deep to about 10 mm deep.

[00152] Embodiment 12 provides the method of any one of Embodiments 1-11, wherein the coating is sufficient to provide a weight gain of about 0.000,01 g/cm ² surface area to about 0.01 g/cm ² surface area.

[00153] Embodiment 13 provides the method of any one of Embodiments 1-12, wherein the coating is sufficient to provide a weight gain of about 0.000, 1 g/cm ² surface area to about 0.1 g/cm ² surface area.

[00154] Embodiment 14 provides the method of any one of Embodiments 1-13, wherein the diffusion of the antioxidant in the antioxidant-coated solid material is sufficient to form a substantially homogenous distribution of the antioxidant in a surface layer of the antioxidant- diffused solid material.

[00155] Embodiment 15 provides the method of Embodiment 14, wherein the surface layer of the antioxidant-diffused solid material comprises a layer of about 1 mm deep.

[00156] Embodiment 16 provides the method of any one of Embodiments 14-15, wherein the surface layer of the antioxidant-diffused solid material comprises a layer of about 1 mm deep to about 10 mm deep.

[00157] Embodiment 17 provides the method of any one of Embodiments 1-16, wherein the diffusion of the antioxidant in the antioxidant-coated solid material is sufficient to allow the antioxidant to penetrate to a depth of at least about 1 mm from a surface of the antioxidant- diffused solid material.

[00158] Embodiment 18 provides the method of Embodiment 17, wherein the diffusion of the antioxidant in the antioxidant-coated solid material is sufficient to allow the antioxidant to penetrate to a depth of at least about 10 mm from a surface of the antioxidant-diffused solid material

[00159] Embodiment 19 provides the method of any one of Embodiments 1- 8, comprising cooling the antioxidant-diffused solid material prior to the irradiating.

[00160] Embodiment 20 provides the method of any one of Embodiments 1 -19, wherein the pre-irradiative heating comprises heating to about 50 °C to about 300 °C.

[00161] Embodiment 21 provides the method of any one of Embodiments 1-20, wherein the pre-irradiative heating comprises heating to about 80 °C to about 250 °C.

[00162] Embodiment 22 provides the method of any one of Embodiments 1-21, wherein the pre-irradiative heating comprises heating sufficiently to melt at least part of the IJHM WPE.

[00163] Embodiment 23 provides the method of any one of Embodiments 1-22, wherein the pre-irradiative heating comprises heating for about 1 minute to about 7 days.

[00164] Embodiment 24 provides the method of any one of Embodiments 1-23, wherein the pre-irradiative heating comprises heating for about 1 hour to about 48 hours.

[00165] Embodiment 25 provides the method of any one of Embodiments 1-24, wherein the pre-irradiative heating comprises preheating before the irradiating.

[00166] Embodiment 26 provides the method of any one of Embodiments 1-25, wherein the pre-irradiative heating comprises preheating to at or above a preheat temperature to provide a preheated antioxidant-diffused solid material, wherein irradiating the antioxidant-diffused solid material comprises irradiating the preheated antioxidant-diffused solid material.

[00167] Embodiment 27 provides the method of any one of Embodiments 1-26, wherein after the pre-irradiative heating, further comprising preheating the antioxidant-diffused solid material at or above a preheat temperature to provide a preheated antioxidant-diffused solid material, wherein irradiating the antioxidant-diffused solid material comprises irradiating the preheated antioxidant-diffused solid material.

[00168] Embodiment 28 provides the method of Embodiment 27, comprising cooling the antioxidant-diffused solid material prior to the preheating.

[00169] Embodiment 29 provides the method of any one of Embodiments 27-28, wherein the preheating comprises heating to about 50 °C to about 300 °C.

[00170] Embodiment 30 provides the method of any one of Embodiments 27-29, wherein the preheating comprises heating to about 1 10 °C to about 130 °C. [00171] Embodiment 3 provides the method of any one of Embodiments 27-30, wherein the preheating comprises heating to a temperature below the melting point of the UHMWPE.

[00172] Embodiment 32 provides the method of any one of Embodiments 27-31, wherein the preheating comprises heating for about 1 minute to about 7 days.

[00173] Embodiment 33 provides the method of any one of Embodiments 27-32, wherein the preheating comprises heating for about 1 hour to about 48 hours.

[00174] Embodiment 34 provides the method of any one of Embodiments 1-33, wherein the irradiating comprises maintaining a minimum temperature during the irradiating.

[00175] Embodiment 35 provides the method of any one of Embodiments 1-34, wherein the irradiating comprises at least one of an electron-beam irradiating and gamma irradiating.

[00176] Embodiment 36 provides the method of any one of Embodiments 1-35, wherein the irradiating comprises irradiating with a dose of about 1 kGy to about 100,000 kGy.

[00177] Embodiment 37 provides the method of any one of Embodiments 1-36, wherein the irradiating comprises irradiating with a dose of about 50 kGy to about 200 kGy,

[00178] Embodiment 38 provides the method of any one of Embodiments 1-37, wherein the irradiating comprises irradiating with a dose rate of about 0,001 mGy/h to about 500 MGy/h.

[00179] Embodiment 39 provides the method of any one of Embodiments 1-38, wherein the irradiating compri ses irradiating with a dose rate of about 1 mGy/h to about 50 MGy/h.

[00180] Embodiment 40 provides the method of any one of Embodiments 1-39, wherein the post-irradiative heating comprises heating to about 50 °C to about 300 °C.

[00181] Embodiment 41 provides the method of any one of Embodiments 1-40, wherein the post-irradiative heating comprises heating to about 80 °C to about 250 °C.

[00182] Embodiment 42 provides the method of any one of Embodiments 1 -41, wherein the post-irradiative heating comprises heating for about 1 minute to about 7 days.

[00183] Embodiment 43 provides the method of any one of Embodiments 1-42, wherein the post-irradiative heating comprises heating for about 1 hour to about 48 hours.

[00184] Embodiment 44 provides the method of any one of Embodiments 1-43, wherein the post-irradiative heating is performed in an environment comprising oxygen.

[00185] Embodiment 45 provides the method of Embodiment 44, wherein the

environment comprising oxygen is about 1 vol% to about 50 vol% oxygen. [00186] Embodiment 46 provides the method of any one of Embodiments 44-45, wherein the environment comprising oxygen is about 10 vol% to about 30 vol% oxygen.

[00187] Embodiment 47 provides the method of any one of Embodiments 1-46, wherein the antioxidant is a free-radical scavenger,

[00188] Embodiment 48 provides the method of any one of Embodiments 1 -47, wherein the antioxidant is at least one of a tocopherol, a tocopherol phosphite, a tocotrienol, vitamin E, vitamin E acetate, a protected vitamin E, a rosemary oil, pentaerythritol tetrakis(3-(3,5-di-tert- butyl-4-hydroxyphenyl)propionate), butanedioic acid dimethyl ester/4-hydroxy-2,2,6,6- tetramethyl-l-piperidine ethanol copolymer, tannic acid, bilberry extract, vitamin C, a carotene, a flavonoid, an isoflavonoid, a neoflavonoid, a lignin, quinine, ubiquinone, vitamin K l , a metal, glutathione, propyl gallate, octyl gallate, !auryl gallate, resveratrol, rosmarinic acid, rutin, 5- aminosalicylic acid, butylated hydroxy anisole, butylated hydroxy toluene, a phenolic compound, and a monomelic or polymeric hindered amine stabilizer.

[00189] Embodiment 49 provides the method of any one of Embodiments 1 -48, wherein the antioxidant is at least one of vitamin E, vitamin E acetate, pentaerythritol tetrakis(3-(3,5-di- tert-butyl-4-hydroxyphenyl)propionate), butanedioic acid dimethyl ester/4-hydroxy-2,2,6,6- tetramethyl-l-piperidine ethanol copolymer, tannic acid, and bilberry extract.

[00190] Embodiment 50 provides the method of any one of Embodiments 1-49, wherein the antioxidant is at least one of racemic alpha-tocopherol, RRR-alpha-tocopherol, SRR-alpha- tocopherol, SSR-alpha-tocopherol, SRS-alpha-tocopherol, SSS-alpha-tocopherol, RSR-alpha- tocopherol, RRS-alpha-tocopherol, RSS-alpha-tocopherol, racemic beta-tocopherol, RRR-beta- tocopheroi, SRR-beta-tocopherol, SSR-beta-tocopherol, SRS-beta-tocopherol, SSS-beta- tocopherol, RSR-beta-tocopherol, RRS-beta-tocopherol, RSS-beta-tocopherol, racemic gamma- tocopherol, RRR-gamma-tocopherol, SRR-gamma-tocopherol, SSR-gamma-tocopherol, SRS- gamma-tocopherol, SSS-gamma-tocopherol, RSR-gamma-tocopherol, RRS-gamma-tocopherol, RSS-gamma-tocopherol, racemic delta-tocopherol, RRR-delta-tocopherol, SRR-delta- tocopherol, SSR-delta-tocopherol, SRS-delta-tocopherol, SSS-delta-tocopherol, RSR-delta- tocopherol, RRS-delta-tocopherol, and RSS-delta-tocopherol.

[00191] Embodiment 51 provides the method of any one of Embodiments 1-50, wherein the antioxidant is a hindered amine stabilizer or a hindered phenol stabilizer. 00192 Embodiment 52 provides the method of Embodiment 51, wherein the hindered amine stabilizer is at least one of a 2,2,6,6-tetra((C ₁ -Cs ₀ )hydrocarbyl)-4-piperidyl diester of HOC(0)-(C]-C ₅ o)hydrocarbyl-C(0)OH, a 2,2,6,6-tetramethyl-4-piperidyl diester of HOC(O)- (C i-C5o)hydrocarbyl-C(0)OH, bis(2,2,6,6-tetramethyl-4-piperidyl) sebacate, l,2,2,6,6~penta((Ci~ C5o)hydrocarbyl)-4-piperidyl diester of HOC(O)-(C -C5 ₀ )hydrocarbyl-C(O)OH, a 1 ,2,2,6,6- pentamethyl-4-piperidyl diester of HOC(O)-(C ₁ -C ₅₀ )hydrocarbyl-C(O)OH, 2,2,6,6- tetramethylpiperidine, wherein each (Ci-C5o)hydrocarbyl is independently selected, is substituted or unsubstituted, and is interrupted by 0, 1, 2, or 3 -O- groups.

[00193] Embodiment 53 provides the method of any one of Embodiments 5 -52, wherein the hindered amine stabilizer or hindered phenol stabilizer has a molecular weight of about 100 to about 2,000.

[00194] Embodiment 54 provides the method of any one of Embodiments 1-53, wherein the antioxidant is a protected tocopherol or tocotrienol having the structure: r a salt thereof, or

OR ^a , or a salt thereof,

wherein

at each occurrence, R ^a is independently chosen from -H, -E, and substituted or unsub sti tuted (C i ~C ₁₀ )hy drocarby 1 ,

E has the structure:

or

R', R ⁸ , and R ⁹ are each independently chosen from -H, substituted or unsubstituted (Ci-Cio)afkyl, and substituted or unsubstituted (C ₁ -C ₁₀ )alkenyl.

[00195] Embodiment 55 provides the method of Embodiment 54, further comprising converting at least some of protected tocopherol or tocotrienol to a compound of the formula E- OH.

[00196] Embodiment 56 provides the method of any one of Embodiments 1 -55, wherein the antioxidant is a hindered amine stabilizer-protected tocopherol or tocotrienol of formula (I):

or a salt thereof,

wherein

R ^! , R\ R ³ , and R ⁴ are each, independently, hydrogen or (Ci-(>!o)alkyl,

R ³ is chosen from hydrogen, (Ci-Cio)aikyi, -0% and -OR ¹¹ wherein R ^u is hydrogen or (Ci-Cio)alkyl,

E has the structure:

wherein R ⁷ , R ⁸ , and R ⁹ are each independently chosen from ~H, substituted bstituted (Ci-Cio)alkyl, and substituted or unsubstituted (Ci-Cio)alkenyf, and

Y represents the group:

wherein R is hydrogen, (Ci-Cio)alkyl, -E, or a radical of the formula:

[00197] Embodiment 57 provides the composition of Embodiment 56, wherein the one or more compounds of the formula (I) are substantially uniformly distributed throughout the ultrahigh molecular weight polyethylene.

[00198] Embodiment 58 provides the composition of any one of Embodiments 56-57, wherein E-O- is a vitamin E radical.

[00199] Embodiment 59 provides the composition of any one of Embodiments 56-58, wherein R ⁶ -0~ is a vitamin E radical.

[00200] Embodiment 60 provides the composition of any one of Embodiments 56-59, wherein R ⁶ is a radical of the formula:

[00201] Embodiment 61 provides the composition of any one of Embodiments 56-60, wherein R ¹ , R ² , R ³ , R , and R ⁵ are each, independently, (Ci-Cio)alkyl.

[00202] Embodiment 62 provides the composition of any one of Embodiments 56-61, wherein R ¹ , R ² , R ^J , R ⁴ , and R ⁵ are each methyl,

[00203] Embodiment 63 provides the composition of any one of Embodiments 56-62, wherein Y represents the group:

R ⁶

O"

vV .

[00204] Embodiment 64 provides the method of any one of Embodiments 56-63, further comprising converting at least some of the compound of the formula (I) to a compound of the formula E-OH, after the irradiating step.

[00205] Embodiment 65 provides the method of any one of Embodiments 1-64, wherein the iixadiated solid material has a first concentration of free-radicals, and the melt-stabilized material has a second concentration of free-radicals.

[00206] Embodiment 66 provides the method of Embodiment 65, wherein the first concentration of free-radicals is at least about 1 x 10 ^l5 spins/g.

[00207] Embodiment 67 provides the method of any one of Embodiments 65-66, wherein the first concentration of free-radicals is about 1 x 10 ¹⁵ spins/gram to about 1 x 10 ²⁰ spins/g.

[00208] Embodiment 68 provides the method of any one of Embodiments 65-67, wherein the second concentration of free-radicals is less than about 1 x 10 ¹⁵ spins/g.

[00209] Embodiment 69 provides the method of any one of Embodiments 65-68, wherein the second concentration of free-radicals is about 1 x 10 ⁵ spins/g to about I x lO ¹⁵ spins/g.

[00210] Embodiment 70 provides the method of any one of Embodiments 65-69, wherein the second concentration of free-radicals is about 1% to about 0.000, 1 % of the first

concentration of free-radicals,

[00211] Embodiment 71 provides the method of any one of Embodiments 65-70, wherein the second concentration of free-radicals is about 0.1% to about 0.001% of the first concentration of free-radicals. [00212] Embodiment 72 provides the method of any one of Embodiments 1-71, wherein the UliMWPE in a surface layer of the melt-stabilized material has an oxidation index that does not exceed 1.

[00213] Embodiment 73 provides the method of Embodiment 72, wherein the surface layer of the melt-stabilized material has an oxidation index of about 0,001 to about 1.

[00214] Embodiment 74 provides the method of any one of Embodiments 72-73, wherein the surface layer of the melt-stabilized material comprises a layer of about 0 mm deep to about 1 mm deep,

[00215] Embodiment 75 provides the method of any one of Embodiments 72-74, wherein the surface layer of the melt-stabilized material comprises a layer of about 1 mm deep to about 10 mm deep.

[ 00216] Embodiment 76 provides the melt-stabilized material of any one of Embodiments 1-75.

[00217] Embodiment 77 provides an orthopedic implant comprising the melt-stabilized material of any one of Embodiments 1-75.

[00218] Embodiment 78 provides a method of preparing an orthopedic implant comprising forming an orthopedic implant from the melt- stabilized material of any one of Embodiments 1- 75,

[00219] Embodiment 79 provides a method of melt-stabilizing ultra high molecular weight polyethylene (UHMWPE), the method comprising:

coating a solid material comprising UHMWPE with a protected vitamin E antioxidant, to provide an antioxidant-coated solid material, wherein the protected vitamin E antioxidant is at least one of at least one of a protected tocopherol or tocotrienol having the structure: r _{a sa} |† thereo or u ^t * , or a salt thereof.

wherein at each occurrence, R ^a is independently chosen from -H, -E, and substituted or unsub sti tuted (C i ~C ₁₀ )hy drocarby 1 ,

E has the structure:

R', R ⁸ , and R ⁹ are each independently chosen from -H, substituted or unsubstituted (Ci-Cjojalkyl, and substituted or un substituted (Ci-Cio)alkenyl, and

a hindered amine stabilizer-protected tocopherol or tocotrienol of formula (I):

(I)

or a salt thereof;

wherein

R ¹ , R ² , R ³ , and R ⁴ are each, independently, hydrogen or (Ci-Cio)ai

R ⁵ is chosen from hydrogen, (Ci-Cio)alkyl, -0% and -OR ¹¹ wherein R ^{! 1} is hydrogen or (Ci-Cio)alkyl, and

Y represents the group:

wherein R ⁶ is hydrogen, (Ci-CioMkyl, -E, or a radical of the formula:

pre-irradiatively heating the antioxidant-coated solid material to diffuse the antioxidant therein, to provide an antioxidant-diffused solid material,

irradiating the antioxidant-diffused solid material, to provide an irradiated solid material; post-irradiatively heating the irradiated solid material, the heating sufficient to melt at least part of the UHMWPE, to provide a heated material; and

solidifying the heated material, to provide a melt-stabilized material.

[00220] Embodiment 80 provides a melt-stabilized ultra high molecular weight polyethylene (UHMWPE) material made by a method comprising:

coating a solid material comprising UHMWPE with an antioxidant, to provide an antioxidant-coated solid material;

pre-irradiatively heating the antioxidant-coated solid material to diffuse the antioxidant therein, to provide an antioxidant-diffused solid material,

irradiating the antioxidant-diffused solid material, to provide an irradiated solid material; post-irradiatively heating the irradiated solid material, the heating sufficient to melt at least part of the UHMWPE, to provide a heated material; and

solidifying the heated material, to provide the melt-stabilized material.

[00221] Embodiment 8 provides the method or composition of any one or any combination of Embodiments 1-80 optionally configured such that all elements or options recited are available to use or select from.