Title:
MEMANTINE DERIVATIVE, PHARMACEUTICAL COMPOSITION THEREOF AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/012565
Kind Code:
A1
Abstract:
The present invention provides a memantine derivative or a stereoisomer, solvate or pharmaceutically acceptable salt thereof, a pharmaceutical composition thereof, and a use in preparing a drug for preventing and/or treating central nervous system diseases, especially Alzheimer's disease, Parkinson's disease or other neurodegenerative diseases. The compound of the present invention has low water solubility, can be well made into a suspension preparation, and has a low dissolution rate in a living body. After a single administration, it can achieve the effect of drug efficacy lasting for several weeks, thereby reducing the number of medication administrations to a patient. This not only improves patient compliance, but also ensures curative effects, and has good application prospects.
Inventors:
LI DEYAO (CN)
ZHOU YIQIAN (CN)
YOU HUAJIN (CN)
GUO QI (CN)
GAO BO (CN)
ZHANG LIJUN (CN)
ZHANG JIANCUN (CN)
ZHOU YIQIAN (CN)
YOU HUAJIN (CN)
GUO QI (CN)
GAO BO (CN)
ZHANG LIJUN (CN)
ZHANG JIANCUN (CN)
Application Number:
PCT/CN2023/107438
Publication Date:
January 18, 2024
Filing Date:
July 14, 2023
Export Citation:
Assignee:
GUANGZHOU HENOVCOM BIOSCIENCE CO LTD (CN)
International Classes:
A61K31/13; C07C271/24; A61K31/16; A61P25/16; A61P25/28
Foreign References:
| CN109152752A | 2019-01-04 | |||
| CN108892771A | 2018-11-27 | |||
| CN107573375A | 2018-01-12 | |||
| US20100144868A1 | 2010-06-10 |
Attorney, Agent or Firm:
GUANGZHOU SINO PATENT & TRADEMARK AGENT CO., LTD. (CN)
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