Title:
MEMBRANE-ASSOCIATED TYROSINE AND THREONINE KINASE INHIBITOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/061343
Kind Code:
A1
Abstract:
The present disclosure relates to a PKMYT1 inhibitor compound represented by formula (I) or a pharmaceutically acceptable salt thereof, a preparation method therefor, a pharmaceutical composition containing the compound or the pharmaceutically acceptable salt thereof, and use thereof in preventing or treating a PKMYT1-related disease. X1 to X5, R1 to R4, R7, and R8 in formula (I) are as defined in the specification.
Inventors:
ZHU DONGXING (CN)
XUE JIANBIN (CN)
WANG WEIKUN (CN)
LIU LANG (CN)
HUAN XIANG (CN)
ZHOU YIKE (CN)
WANG TAO (CN)
ZHU WEI (CN)
LI ZHENGTAO (CN)
XUE JIANBIN (CN)
WANG WEIKUN (CN)
LIU LANG (CN)
HUAN XIANG (CN)
ZHOU YIKE (CN)
WANG TAO (CN)
ZHU WEI (CN)
LI ZHENGTAO (CN)
Application Number:
PCT/CN2023/120664
Publication Date:
March 28, 2024
Filing Date:
September 22, 2023
Export Citation:
Assignee:
SIMCERE ZAIMING PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D487/16; A61K31/395; A61K31/437; A61P35/00; C07D471/16; C07D471/22; C07D487/22
Domestic Patent References:
| WO2021195781A1 | 2021-10-07 | |||
| WO2021195782A1 | 2021-10-07 | |||
| WO2011103430A1 | 2011-08-25 |
Foreign References:
| CN112996794A | 2021-06-18 | |||
| CN103772395A | 2014-05-07 |
Attorney, Agent or Firm:
INSIGHT INTELLECTUAL PROPERTY LTD. (CN)
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