Title:
MEMBRANE PERMEATION ENHANCER, MEMBRANE PERMEATION ENHANCEMENT METHOD, AND INTRACELLULAR DELIVERY METHOD
Document Type and Number:
WIPO Patent Application WO/2023/027006
Kind Code:
A1
Abstract:
Provided are: a membrane permeation enhancer that contains a surfactant having a steroid backbone, and enhances permeation of a complex of an intended substance and a membrane-permeable substance through a lipid bimolecular membrane; and a membrane permeation enhancement method using the membrane permeation enhancer. The present invention also provides: an intracellular delivery method for delivering an intended substance into a cell by bringing a complex of the intended substance and a membrane-permeable substance into contact with the cell in the presence of a membrane permeation enhancer; and a kit that is for intracellular delivery and that is suitably used in the intracellular delivery method.
Inventors:
SAKAI HIDEKI (JP)
SAKAMOTO KAZUTAMI (JP)
YOKOYAMA KIICHI (JP)
IGARASHI YUSAKU (JP)
AKAMATSU MASAAKI (JP)
SAKAI KENICHI (JP)
SAKAMOTO KAZUTAMI (JP)
YOKOYAMA KIICHI (JP)
IGARASHI YUSAKU (JP)
AKAMATSU MASAAKI (JP)
SAKAI KENICHI (JP)
Application Number:
PCT/JP2022/031507
Publication Date:
March 02, 2023
Filing Date:
August 22, 2022
Export Citation:
Assignee:
UNIV TOKYO SCIENCE FOUND (JP)
International Classes:
A61K47/28; C07K5/09; C07K5/11; C07K7/04; C12N15/09
Domestic Patent References:
| WO2021054351A1 | 2021-03-25 |
Foreign References:
| JP2005154413A | 2005-06-16 | |||
| JPH08507759A | 1996-08-20 |
Other References:
NAZARI MOZHGAN, KURDI MUSTAFA, HEERKLOTZ HEIKO: "Classifying Surfactants with Respect to Their Effect on Lipid Membrane Order", BIOPHYSICAL JOURNAL, ELSEVIER, AMSTERDAM, NL, vol. 102, no. 3, 1 February 2012 (2012-02-01), AMSTERDAM, NL, pages 498 - 506, XP093039040, ISSN: 0006-3495, DOI: 10.1016/j.bpj.2011.12.029
YAMAMOTO AKIRA: "Improvement of transmucosal absorption of peptide and protein drugs", DRUG DELIVERY SYSTEM, TOKYO, vol. 15, no. 6, 1 November 2000 (2000-11-01), Tokyo, pages 507 - 519, XP093039036, DOI: 10.2745/dds.15.507
YAMAMOTO AKIRA: "Improvement of transmucosal absorption of peptide and protein drugs", DRUG DELIVERY SYSTEM, TOKYO, vol. 15, no. 6, 1 November 2000 (2000-11-01), Tokyo, pages 507 - 519, XP093039036, DOI: 10.2745/dds.15.507
Attorney, Agent or Firm:
SHOBAYASHI Masayuki et al. (JP)
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