Title:
MERCAPTO-GROUP MODIFIED MACROMOLECULE DERIVATIVE AND CROSS-LINKED MATERIAL
Document Type and Number:
WIPO Patent Application WO/2008/071058
Kind Code:
A1
Abstract:
A mercapto-group modified macromolecule derivative having the general formula of (I) or (II), as well as the disulfide bond cross-linked material and a material cross-linked by a mercapto-reactive crosslinker that made from the derivative, wherein R1 and R2 are alkylene groups, substituted alkylene groups, aromatic groups or polyether groups and the like, respectively. R1 and R2 may have same or different chemical structure, and P is a residue of a macromolecule whose side chain has carboxyl group. The mercapto-group modified macromolecule derivative has a molecular weight of from 1000 to 5,000,000. The mercapto-group modified macromolecule derivative having the general formula of (I) or (II) of the present invention has a side chain with flexible chemical structure and adjustable properties, and has a number of advantages, such as mild reaction condition, high production yield, high degree of modifying, and the modifying degree being controllable and so on. The cross-linked material made from the mercapto-group modified macromolecule derivative of the present invention can be used to inhibit cell attachment and be used as the matrix for cell attachment growth.
Inventors:
SONG CHAN (CN)
Application Number:
PCT/CN2007/002864
Publication Date:
June 19, 2008
Filing Date:
September 29, 2007
Export Citation:
Assignee:
BIOREGEN BIOMEDICAL SHANGHAI C (CN)
SONG CHAN (CN)
SONG CHAN (CN)
International Classes:
C08B37/00; C08G18/00; C08H1/00; C08H99/00; A61K31/728; C07B43/06; C07C241/04; C07K1/107
Domestic Patent References:
| WO2004037164A2 | 2004-05-06 | |||
| WO2005056608A1 | 2005-06-23 | |||
| WO2004003716A1 | 2004-01-08 |
Foreign References:
| US20040038934A1 | 2004-02-26 | |||
| EP1683812A1 | 2006-07-26 | |||
| US20060110458A1 | 2006-05-25 | |||
| JPS6357569A | 1988-03-12 |
Other References:
XIAO Z. ET AL.: "Disulfide Cross-Linked Hyaluronan Hydrogels", BIOMACROMOLECULES, vol. 3, no. 6, 2002, pages 1304 - 1311, XP002975311
SHU ET AL., BIOMACROMOLECULES, vol. 3, 2002, pages 1304
BIOMACROMOLECULES, vol. 3, 2002, pages 1304
SHU ET AL., BIOMATERIALS, vol. 24, 2003, pages 3825
SHU, BIOMACROMOLECULES, vol. 3, 2002, pages 1304
SHU, BIOMACROMOLECULES, vol. 3, 2002, pages 1304
SHU ET AL., BIOMACROMOLECULES, vol. 3, 2002, pages 1304
BIOMACROMOLECULES, vol. 3, 2002, pages 1304
SHU ET AL., BIOMATERIALS, vol. 24, 2003, pages 3825
SHU, BIOMACROMOLECULES, vol. 3, 2002, pages 1304
SHU, BIOMACROMOLECULES, vol. 3, 2002, pages 1304
Attorney, Agent or Firm:
DING & ASSOCIATES PATENT TRADEMARK & LAW (Zhang Jiang High-Tech ZonePu Dong, Shanghai 3, CN)
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