Title:
MERKEL CELL ACTIVATOR, SYNAPTIC VESICLE ENHANCER, NEUROTRANSMITTER RELEASE ACCELERATOR, METHOD FOR ASSESSING NEUROTRANSMITTER RELEASE ACTIVITY OF MERKEL CELLS, AND METHOD FOR SCREENING FOR NEUROTRANSMITTER RELEASE ACCELERATOR FOR MERKEL CELLS
Document Type and Number:
WIPO Patent Application WO/2022/202714
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide skin care focusing on the sense of touch. It was found that sandalore and an analog thereof have an action of activating Merkel cells. Provided is a Merkel cell activator containing sandalore and an analog thereof. It was also found that an activated Merkel cell contains a large number of synaptic vesicles. Provided is a synaptic vesicle enhancer containing sandalore and an analog thereof. It was also found that the neurotransmitter release activity of Merkel cells can be assessed by measuring, under a fluorescence microscope, changes in fluorescent luminance value before and after depolarization stimulation to Merkel cells that have taken in a fluorescent tracer. Provided is a method for screening for a neurotransmitter release accelerator for Merkel cells.
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Inventors:
TOJYO MOE (JP)
KAJIYA KENTARO (JP)
SAKAGUCHI SAITO (JP)
KAJIYA KENTARO (JP)
SAKAGUCHI SAITO (JP)
Application Number:
PCT/JP2022/012849
Publication Date:
September 29, 2022
Filing Date:
March 18, 2022
Export Citation:
Assignee:
SHISEIDO CO LTD (JP)
International Classes:
A61K31/045; A61K8/34; A61P17/00; A61P25/00; A61P25/02; A61P43/00; A61Q19/00; C12N5/071; C12Q1/02; G01N33/15; G01N33/483; G01N33/50
Foreign References:
| JP2011098898A | 2011-05-19 | |||
| JP2019519502A | 2019-07-11 | |||
| JP2017518324A | 2017-07-06 | |||
| JP2019519502A | 2019-07-11 |
Other References:
HOFFMAN BENJAMIN U.; BABA YOSHICHIKA; GRIFFITH THEANNE N.; MOSHAROV EUGENE V.; WOO SEUNG-HYUN; ROYBAL DANIEL D.; KARSENTY GERARD; : "Merkel Cells Activate Sensory Neural Pathways through Adrenergic Synapses", NEURON, ELSEVIER, AMSTERDAM, NL, vol. 100, no. 6, 1 January 1900 (1900-01-01), AMSTERDAM, NL, pages 1401, XP085562541, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2018.10.034
NATURE, vol. 509, 2014, pages 622 - 626
J INVESTIGATIVE DERMATOLOGY, vol. 134, 2014, pages 2823 - 2832
NAT COMMUN., vol. 9, no. 1, 18 September 2018 (2018-09-18), pages 3624
JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 134, 2014, pages 2823 - 2832
NEURON, vol. 100, no. 6, 2018, pages 1401 - 1413
SCIENCE, vol. 360, no. 6388, 4 May 2018 (2018-05-04), pages 530 - 533
SCI TRANSL MED., vol. 10, no. 462, 2018, pages 9892
PLOS GENET, vol. 12, no. 7, 14 July 2016 (2016-07-14), pages 1006151
NATURE, vol. 509, 2014, pages 622 - 626
J INVESTIGATIVE DERMATOLOGY, vol. 134, 2014, pages 2823 - 2832
NAT COMMUN., vol. 9, no. 1, 18 September 2018 (2018-09-18), pages 3624
JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 134, 2014, pages 2823 - 2832
NEURON, vol. 100, no. 6, 2018, pages 1401 - 1413
SCIENCE, vol. 360, no. 6388, 4 May 2018 (2018-05-04), pages 530 - 533
SCI TRANSL MED., vol. 10, no. 462, 2018, pages 9892
PLOS GENET, vol. 12, no. 7, 14 July 2016 (2016-07-14), pages 1006151
Attorney, Agent or Firm:
AOKI, Atsushi et al. (JP)
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