Title:
MESENCHYMAL STEM CELLS AS IMMUNOSUPPRESSANTS
Document Type and Number:
WIPO Patent Application WO1999051275
Kind Code:
A3
Abstract:
The present invention provides a method to modulate immune responses using antigen presenting human mesenchymal stem cells to induce specific T cell anergy. The present invention also provides a method to modulate immune responses using human mesenchymal stem cells as a platform to express molecules which will induce T cell anergy.
Inventors:
MOSCA JOSEPH D
MCINTOSH KEVIN R
MCINTOSH KEVIN R
Application Number:
PCT/US1999/005350
Publication Date:
December 09, 1999
Filing Date:
March 12, 1999
Export Citation:
Assignee:
OSIRIS THERAPEUTICS INC (US)
International Classes:
A61K45/00; A61K48/00; A61P37/02; A61P37/06; C07K14/705; C12N5/0775; A61K35/12; A61K38/00; A61K39/00; (IPC1-7): A61K48/00
Foreign References:
| US5591625A | 1997-01-07 |
Other References:
MOSCA, J. D. ET AL: "Human marrow-derived mesenchymal stem cells interact with mature T-lymphocytes.", MOLECULAR BIOLOGY OF THE CELL, (NOV., 1997) VOL. 8, NO. SUPPL., PP. 69A. MEETING INFO.: 37TH ANNUAL MEETING OF THE AMERICAN SOCIETY FOR CELL BIOLOGY WASHINGTON, D.C., USA DECEMBER 13-17, 1997, XP002118099
KIRK A D ET AL: "CTLA4 -Ig and anti-CD40 ligand prevent renal allograft rejection in primates.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, (1997 AUG 5) 94 (16) 8789-94., XP002118100
M KEANE-MOORE ET AL: "Human mesenchymal stem cells can be genetically modifed to function as antigen presenting cells", BLOOD, vol. 92, no. 10, 15 November 1998 (1998-11-15), pages 338A, XP002094072, ISSN: 0006-4971
KLYUSHNENKOVA, E. ET AL: "Human Mesenchymal Stem Cells suppress allogeneic T cell responses in vitro: Implications for allogeneic transplantation.", BLOOD, (NOV. 15, 1998) VOL. 92, NO. 10 SUPPL. 1 PART 1-2, PP. 642A. MEETING INFO.: 40TH ANNUAL MEETING OF THE AMERICAN SOCIETY OF HEMATOLOGY MIAMI BEACH, FLORIDA, USA DECEMBER 4-8, 1998, XP002118101
KIRK A D ET AL: "CTLA4 -Ig and anti-CD40 ligand prevent renal allograft rejection in primates.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, (1997 AUG 5) 94 (16) 8789-94., XP002118100
M KEANE-MOORE ET AL: "Human mesenchymal stem cells can be genetically modifed to function as antigen presenting cells", BLOOD, vol. 92, no. 10, 15 November 1998 (1998-11-15), pages 338A, XP002094072, ISSN: 0006-4971
KLYUSHNENKOVA, E. ET AL: "Human Mesenchymal Stem Cells suppress allogeneic T cell responses in vitro: Implications for allogeneic transplantation.", BLOOD, (NOV. 15, 1998) VOL. 92, NO. 10 SUPPL. 1 PART 1-2, PP. 642A. MEETING INFO.: 40TH ANNUAL MEETING OF THE AMERICAN SOCIETY OF HEMATOLOGY MIAMI BEACH, FLORIDA, USA DECEMBER 4-8, 1998, XP002118101
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