Title:
AXL＆C-MET DUAL INHIBITOR, AND PREPARATION METHOD AND USE
Document Type and Number:
WIPO Patent Application WO/2024/022095
Kind Code:
A1
Abstract:
Disclosed in the present invention are a class of Axl&c-Met dual inhibitors, and a preparation method therefor and the use thereof. The inhibitor is a compound as represented by formula (I) or a pharmaceutically acceptable salt, prodrug, hydrate or solvate thereof, wherein R1 is hydrogen, halogen, substituted or unsubstituted alkyl, alkoxy or haloalkoxy, substituted or unsubstituted cycloalkyl, or substituted or unsubstituted aryl; R2 is halogen, or substituted or unsubstituted alkyl; and the value of n is 1 or 2. The Axl&c-Met dual inhibitor of the present invention has excellent pharmacokinetic properties and is expected to be developed into an anti-tumor drug. In particular, the series of inhibitors have an effective blood-brain barrier penetration ability, have good exposure in brain tissues, and can be used for developing drugs for brain tumors such as brain glioma and brain metastatic tumors.
Inventors:
XIE JUN (CN)
JIANG CHUNYANG (CN)
LI HUI (CN)
PEI XINYU (CN)
SHU HAIYING (CN)
JIANG CHUNYANG (CN)
LI HUI (CN)
PEI XINYU (CN)
SHU HAIYING (CN)
Application Number:
PCT/CN2023/106523
Publication Date:
February 01, 2024
Filing Date:
July 10, 2023
Export Citation:
Assignee:
SHANGHAI SCIENPHARM CO LTD (CN)
International Classes:
C07D401/14; A61K31/444; A61K31/506; A61P35/00
Domestic Patent References:
| WO2020042618A1 | 2020-03-05 | |||
| WO2011139891A1 | 2011-11-10 | |||
| WO2016104617A1 | 2016-06-30 | |||
| WO2021198709A1 | 2021-10-07 |
Foreign References:
| US20140343103A1 | 2014-11-20 | |||
| CN101128199A | 2008-02-20 | |||
| CN110330479A | 2019-10-15 |
Attorney, Agent or Firm:
DUAN & DUAN LAW FIRM (CN)
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