Title:
METABOLIC ENGINEERING FOR ENHANCED PRODUCTION OF CHITIN AND CHITOSAN IN MICROORGANISMS
Document Type and Number:
WIPO Patent Application WO2004092391
Kind Code:
A3
Abstract:
Disclosed is a fermentation method for the production of commercially useful amounts of chitin and/or chitosan by a biosynthetic process. Also disclosed are genetically modified microorganisms useful in such a method and a microbial biomass containing chitin and/or chitosan produced by such a method.
Inventors:
DENG MING-DE
MCMULLIN THOMAS W
GRUND ALAN D
MCMULLIN THOMAS W
GRUND ALAN D
Application Number:
PCT/US2004/011286
Publication Date:
November 24, 2005
Filing Date:
April 12, 2004
Export Citation:
Assignee:
ARKION LIFE SCIENCES LLC (US)
International Classes:
C07H21/04; C12N1/18; C12N1/20; C12N9/00; C12N9/10; C12N9/24; C12N9/80; C12N9/88; C12N15/00; C12N15/52; C12P19/04; C12P19/26; C12P19/28; C12P21/06; C12P; (IPC1-7): C12P21/06; C07H21/04; C12N1/20; C12N9/00; C12N15/00
Other References:
LAGORCE A. ET AL.: "Involvement of GFA1, which encodes glutamine-fructose-6-phosphate amidotransferase, in the activation of the chitin synthesis pathway in response to cell-wall defects in S.cerevisiae", EUR J BIOCHEM., vol. 269, no. 6, 6 March 2002 (2002-03-06), pages 1697 - 1707, XP002989688
KURANDA M.J. ET AL: "Cloning and heterologous expression of glycosidase genes from S.cerevisiae", NATL.ACAD.SCI., vol. 84, May 1987 (1987-05-01), pages 2585 - 2589, XP008051824
SMITH R. ET AL: "Isolation and characterization of the GFA1 gene encoding the glutamine:fructose-6-phosphate amidotransferase of C. albicans.", J.BATERIOL., vol. 178, no. 8, April 1996 (1996-04-01), pages 2320 - 2327, XP002102817
MISHRA C. ET AL.: "Cloning and expression of two chitin deacetylase genes of S.cerevisiae.", YEAST, vol. 13, March 1997 (1997-03-01), pages 327 - 336, XP000879300
KURANDA M.J. ET AL: "Cloning and heterologous expression of glycosidase genes from S.cerevisiae", NATL.ACAD.SCI., vol. 84, May 1987 (1987-05-01), pages 2585 - 2589, XP008051824
SMITH R. ET AL: "Isolation and characterization of the GFA1 gene encoding the glutamine:fructose-6-phosphate amidotransferase of C. albicans.", J.BATERIOL., vol. 178, no. 8, April 1996 (1996-04-01), pages 2320 - 2327, XP002102817
MISHRA C. ET AL.: "Cloning and expression of two chitin deacetylase genes of S.cerevisiae.", YEAST, vol. 13, March 1997 (1997-03-01), pages 327 - 336, XP000879300
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