Title:
METABOLICALLY ENGINEERED CELLS FOR THE PRODUCTION OF POLYUNSATURATED FATTY ACIDS
Document Type and Number:
WIPO Patent Application WO2005118814
Kind Code:
A9
Abstract:
The present invention relates to the construction and engineering of cells, more particularly microorganisms for producing PUFAs with four or more double bonds from non-fatty acid substrates through heterologous expression of an oxygen requiring pathway. The invention especially involves improvement of the PUFA content in the host organism through fermentation optimization, e.g. decreasing the temperature and/or designing an optimal medium, or through improving the flux towards fatty acids by metabolic engineering, e.g. through over-expression of fatty acid synthases, over-expression of other enzymes involved in biosynthesis of the precursor for PUFAs, or codon optimization of the heterologous genes, or expression of heterologous enzymes involved in the biosynthesis of the precursor for PUFAs.
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Inventors:
FOERSTER JOCHEN (DK)
GUNNARSSON NINA KATARINA (DK)
NIELSEN JENS BREDAL (DK)
GUNNARSSON NINA KATARINA (DK)
NIELSEN JENS BREDAL (DK)
Application Number:
PCT/DK2005/000372
Publication Date:
February 09, 2006
Filing Date:
June 03, 2005
Export Citation:
Assignee:
FLUXOME SCIENCES AS (DK)
FOERSTER JOCHEN (DK)
GUNNARSSON NINA KATARINA (DK)
NIELSEN JENS BREDAL (DK)
FOERSTER JOCHEN (DK)
GUNNARSSON NINA KATARINA (DK)
NIELSEN JENS BREDAL (DK)
International Classes:
A23L1/30; A61K8/36; A61K8/67; A61Q19/00; C11B1/00; C12N9/02; C12N9/10; C12N15/52; C12P7/64; (IPC1-7): C12N15/52; C12N15/53; C12N15/54; C12N9/02; C12N9/10; C12N1/19; C12P7/64; A23L1/30; A23D9/00; A23K1/16; A61K7/00
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