METABOLITES OF SELECTIVE ANDROGEN RECEPTOR MODULATORS AND METHODS OF USE THEREOF

WIPO Patent Application WO2005113565

A3

This invention provides metabolites of a class of androgen receptor targeting agents (ARTA). The SARM compounds and their metabolites, either alone or as a composition, are useful for a) male contraception; b) treatment of a variety of hormone-related conditions, for example conditions associated with Androgen Decline in Aging Male (ADAM), such as fatigue, depression, decreased libido, sexual dysfunction, erectile dysfunction, hypogonadism, osteoporosis, hair loss, anemia, obesity, sarcopenia, osteopenia, osteoporosis, benign prostate hyperplasia, alterations in mood and cognition and prostate cancer; c) treatment of conditions associated with Androgen Decline in Female (ADIF), such as sexual dysfunction, decreased sexual libido, hypogonadism, sarcopenia, osteopenia, osteoporosis, alterations in cognition, and mood, depression, anemia, hair loss, obesity, endometriosis, breast cancer, uterine cancer and ovarian cancer; d) treatment and/or prevention of acute and/or chronic muscular wasting conditions; e) preventing and/or treating dry eye conditions; f) oral androgen replacement therapy; g) decreasing the incidence of, halting or causing a regression of prostate cancer; and/or h) inducing apoptosis in a cancer cell.

DALTON JAMES T (US)
MILLER DUANE D (US)
YIN DONGHUA (US)
HE YALI (US)

PCT/US2005/017588

July 27, 2006

March 19, 2005

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UNIV TENNESSEE RES FOUNDATION (US)
DALTON JAMES T (US)
MILLER DUANE D (US)
YIN DONGHUA (US)
HE YALI (US)

A61K31/275; A61K31/70; C07C233/05; C07C233/87; C07C235/24; C07C255/49; C07F7/22; C07G3/00

US4636505A	1987-01-13
US6019957A	2000-02-01

See also references of EP 1750694A4

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