Title:
METAL COMPLEX, INTERMEDIATE, AND PREPARATION METHOD AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/073962
Kind Code:
A1
Abstract:
Provided is a metal complex as represented by formula I. The metal complex may be used as a catalyst for asymmetric catalytic hydrogenation, is capable of efficiently catalyzing and synthesizing a series of chiral β-aryl amides having high optical purity, and is especially capable of asymmetrically catalyzing and hydrogenating a tetra-substituted enamide compound, chiral amides having high optical purity are synthesized, and the carrying amount of ligand may reach 100,000.
Inventors:
TANG WENJUN (CN)
XU SIYAO (CN)
XU SIYAO (CN)
Application Number:
PCT/CN2019/110401
Publication Date:
April 16, 2020
Filing Date:
October 10, 2019
Export Citation:
Assignee:
SHANGHAI INSITITUTE OF ORGANIC CHEMISTRY CHINESE ACAD OF SCIENCES (CN)
International Classes:
C07F15/00; B01J31/24; C07C231/12; C07C233/05; C07C233/06; C07C233/47
Domestic Patent References:
| WO2011056737A1 | 2011-05-12 |
Foreign References:
| CN105859783A | 2016-08-17 | |||
| CN104650145A | 2015-05-27 | |||
| CN107445999A | 2017-12-08 | |||
| CN103087105A | 2013-05-08 | |||
| CN201811178107A | 2018-10-10 |
Other References:
HB KAGANTP DANG, J. AM. CHEM. SOC., vol. 94, 1972, pages 6429
Z. ZHANGG. ZHUQ. JIANGD. XIAOX. ZHANG, J. ORG. CHEM., vol. 64, 1999, pages 1774 - 1775
W. TANGY. CHIX. ZHANG, ORG. LETT., vol. 4, 2002, pages 1695 - 1698
P. DUPAUC. BRUNEAUPH DIXNEUF, ADV. SYNTH. CATAL., vol. 343, 2001, pages 331 - 334
E. SALOMOS. ORGUEA. RIERAX. VERDAGUER, ANGEW. CHEM. INT. ED., vol. 55, 2016, pages 7988 - 7992
See also references of EP 3865494A4
Z. ZHANGG. ZHUQ. JIANGD. XIAOX. ZHANG, J. ORG. CHEM., vol. 64, 1999, pages 1774 - 1775
W. TANGY. CHIX. ZHANG, ORG. LETT., vol. 4, 2002, pages 1695 - 1698
P. DUPAUC. BRUNEAUPH DIXNEUF, ADV. SYNTH. CATAL., vol. 343, 2001, pages 331 - 334
E. SALOMOS. ORGUEA. RIERAX. VERDAGUER, ANGEW. CHEM. INT. ED., vol. 55, 2016, pages 7988 - 7992
See also references of EP 3865494A4
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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