Title:
METAL RADIOLABELED PET IMAGING AGENTS
Document Type and Number:
WIPO Patent Application WO2005087275
Kind Code:
A3
Abstract:
The invention relates to radiolabeled PET agents including a radioisotope, a chelator and a specific ligand. The radioisotope may include 60Cu, 62Cu, 61Cu, 64Cu and 68Ga. Generator-produced 68Ga radioisotopes may be used. Specific chelators include N2S2 moieties and N3S moieties. Specific ligands may include purine and pyrimidine bases, particularly adenine and guanine, a sugar-containing base, particularly glucosamine, galactosamine, or mannosamine, or a nitroimidazole analogue, such as a 2-nitroimidazole or a 5-nitroimidazole, particularly metronidazole. Radiolabeled agents may be formed by first forming a chelator-ligand complex, which may be stored until it is needed, at which time the radioisotope may be added. Radiolabeled agents may be used in traditional PET imaging or in dynamic PET imaging.
Inventors:
CHAO K S CLIFFORD (US)
YANG DAVID J (US)
YANG DAVID J (US)
Application Number:
PCT/US2005/007686
Publication Date:
June 08, 2006
Filing Date:
March 09, 2005
Export Citation:
Assignee:
UNIV TEXAS (US)
CHAO K S CLIFFORD (US)
YANG DAVID J (US)
CHAO K S CLIFFORD (US)
YANG DAVID J (US)
International Classes:
A61K51/04
Domestic Patent References:
| WO2000043004A1 | 2000-07-27 | |||
| WO2001091807A2 | 2001-12-06 | |||
| WO2004044227A2 | 2004-05-27 |
Other References:
HEPPELER A ET AL: "RECEPTOR TARGETING FOR TUMOR LOCALISATION AND THERAPY WITH RADIOPETIDES", CURRENT MEDICINAL CHEMISTRY, BENTHAM SCIENCE PUBLISHERS BV, BE, vol. 7, no. 9, 2000, pages 971 - 994, XP000982225, ISSN: 0929-8673
HENZE M ET AL: "PET imaging of somatostatin receptors using [68GA]DOTA-D-Phe1-Tyr3-Octreotide: first results in patients with meningiomas", JOURNAL OF NUCLEAR MEDICINE, NEW YORK, NY, US, vol. 42, no. 7, July 2001 (2001-07-01), pages 1053 - 1056, XP002245466, ISSN: 0161-5505
HOFMANN M ET AL: "Biokinetics and imaging with the somatostatin receptor PET radioligand <68>Ga-DOTATOC: Preliminary data", EUROPEAN JOURNAL OF NUCLEAR MEDICINE 2001 GERMANY, vol. 28, no. 12, 2001, pages 1751 - 1757, XP002351670, ISSN: 0340-6997
PAGANI M ET AL: "Alternative positron emission tomography with non-conventional positron emitters: Effects of their physical properties on image quality and potential clinical applications", EUROPEAN JOURNAL OF NUCLEAR MEDICINE 1997 GERMANY, vol. 24, no. 10, 1997, pages 1301 - 1327, XP002351671, ISSN: 0340-6997
GOODWIN D A ET AL: "Rapid synthesis and quality control of <68>Ga-labeled chelates for clinical use", NUCLEAR MEDICINE AND BIOLOGY 1994 UNITED KINGDOM, vol. 21, no. 6, 1994, pages 897 - 899, XP002351672, ISSN: 0969-8051
HENZE M ET AL: "PET imaging of somatostatin receptors using [68GA]DOTA-D-Phe1-Tyr3-Octreotide: first results in patients with meningiomas", JOURNAL OF NUCLEAR MEDICINE, NEW YORK, NY, US, vol. 42, no. 7, July 2001 (2001-07-01), pages 1053 - 1056, XP002245466, ISSN: 0161-5505
HOFMANN M ET AL: "Biokinetics and imaging with the somatostatin receptor PET radioligand <68>Ga-DOTATOC: Preliminary data", EUROPEAN JOURNAL OF NUCLEAR MEDICINE 2001 GERMANY, vol. 28, no. 12, 2001, pages 1751 - 1757, XP002351670, ISSN: 0340-6997
PAGANI M ET AL: "Alternative positron emission tomography with non-conventional positron emitters: Effects of their physical properties on image quality and potential clinical applications", EUROPEAN JOURNAL OF NUCLEAR MEDICINE 1997 GERMANY, vol. 24, no. 10, 1997, pages 1301 - 1327, XP002351671, ISSN: 0340-6997
GOODWIN D A ET AL: "Rapid synthesis and quality control of <68>Ga-labeled chelates for clinical use", NUCLEAR MEDICINE AND BIOLOGY 1994 UNITED KINGDOM, vol. 21, no. 6, 1994, pages 897 - 899, XP002351672, ISSN: 0969-8051
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