Title:
METALLO-β-LACTAMASE INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2007/034924
Kind Code:
A1
Abstract:
Disclosed is a metallo-β-lactamase inhibitor which can inactivate a β-lactam antibiotic and recover the anti-bacterial activity of the β-lactam antibiotic. A maleic acid derivative having a structure of the general formula (I) has an inhibitory activity against metallo-β-lactamase. The use of the compound (I) in combination with a β-lactam antibiotic enables to recover the anti-bacterial activity of the β-lactam antibiotic against a bacterium capable of producing mettalo-β-lactamase.
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Inventors:
CHIKAUCHI KEN (JP)
KURAZONO MIZUYO (JP)
ABE TAKAO (JP)
HIRAIWA YUKIKO (JP)
MORINAKA AKIHIRO (JP)
KUDO TOSHIAKI (JP)
KURAZONO MIZUYO (JP)
ABE TAKAO (JP)
HIRAIWA YUKIKO (JP)
MORINAKA AKIHIRO (JP)
KUDO TOSHIAKI (JP)
Application Number:
PCT/JP2006/318879
Publication Date:
March 29, 2007
Filing Date:
September 22, 2006
Export Citation:
Assignee:
MEIJI SEIKA KAISHA (JP)
CHIKAUCHI KEN (JP)
KURAZONO MIZUYO (JP)
ABE TAKAO (JP)
HIRAIWA YUKIKO (JP)
MORINAKA AKIHIRO (JP)
KUDO TOSHIAKI (JP)
CHIKAUCHI KEN (JP)
KURAZONO MIZUYO (JP)
ABE TAKAO (JP)
HIRAIWA YUKIKO (JP)
MORINAKA AKIHIRO (JP)
KUDO TOSHIAKI (JP)
International Classes:
A61K31/194; A61K31/225; A61K31/341; A61K31/351; A61K31/4164; A61K31/4406; A61K31/445; A61K31/4453; A61K31/495; A61K31/5375; A61K45/00; A61P31/04; A61P43/00; C07C57/145; C07C57/26; C07C57/42; C07C57/48; C07C57/50; C07C59/42; C07C59/46; C07C59/52; C07C59/60; C07C59/68; C07C65/00; C07C69/60; C07C69/618; C07C69/675; C07C69/736; C07C217/22; C07C233/65; C07C235/06; C07C237/06; C07C279/08; C07C323/54
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DATABASE CAPLUS [online] XP003010784, Database accession no. (2004:42625)
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CHEM. COMMUN., 1998, pages 1609
BIOCHEM. J., vol. 331, 1998, pages 703
CLIN. MICROBIOL.REV., vol. 18, 2005, pages 306
ACTA CHEM. SCAND., vol. 18, 1964, pages 1276
BIOORG. MED. CHEM., vol. 8, 2000, pages 571
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ANGEW. CHEM., vol. 102, 1990, pages 1164
"The Dictionary of Pharmaceutical Additives", JAPAN PHARMACEUTICAL EXCIPIENTS COUNCIL
T. W. GREENE ET AL.: "Protective Groups in Organic Synthesis", 1999, WILEY
E. S. RATEMI ET AL., J. ORG. CHEM., vol. 61, 1996, pages 6296
M. J. KATES ET AL., J. ORG. CHEM., vol. 61, 1996, pages 4164
H. HAGIWARA ET AL., SYNTHETIC COMMUN., vol. 14, 1984, pages 1193
S. B. SINGH ET AL., BIOORG. MED. CHEM., vol. 8, 2000, pages 571
A. M. DESPANDE ET AL., SYNTHESIS, vol. 5, 2001, pages 702
See also references of EP 1941873A4
DATABASE CAPLUS [online] FOTIN V.V. ET AL.: "Reactions of alpha-bromo esters with zinc and acyl chlorides in the presence of dioxane", XP003010783, Database accession no. (2000:213420)
DATABASE CAPLUS [online] XP003010784, Database accession no. (2004:42625)
DATABASE CAPLUS [online] GOSSAUER A. ET AL.: "Syntheses of bile pigments. V. Stereospecific total synthesis of diastereomeric mesobilirhodins and isomesobilirhodins", XP003010785, Database accession no. (1977:534900)
BIOL. PHARM. BULL., vol. 20, 1997, pages 1136
FEMS MICROBIOLOGY LETTERS, vol. 157, 1997, pages 171
ANTIMICROB. AGENTS CHEMOTHER., vol. 41, 1997, pages 135
CHEM. COMMUN., 1998, pages 1609
BIOCHEM. J., vol. 331, 1998, pages 703
CLIN. MICROBIOL.REV., vol. 18, 2005, pages 306
ACTA CHEM. SCAND., vol. 18, 1964, pages 1276
BIOORG. MED. CHEM., vol. 8, 2000, pages 571
J. AM. CHEM. SOC., vol. 77, no. 6702, 1955
J. ORG. CHEM., vol. 49, 1984, pages 1985
TETRAHEDRON LETT., vol. 29, 1988, pages 3869
NORD. PULP PAP. RES. J., vol. 9, 1994, pages 84
ANGEW. CHEM., vol. 102, 1990, pages 1164
"The Dictionary of Pharmaceutical Additives", JAPAN PHARMACEUTICAL EXCIPIENTS COUNCIL
T. W. GREENE ET AL.: "Protective Groups in Organic Synthesis", 1999, WILEY
E. S. RATEMI ET AL., J. ORG. CHEM., vol. 61, 1996, pages 6296
M. J. KATES ET AL., J. ORG. CHEM., vol. 61, 1996, pages 4164
H. HAGIWARA ET AL., SYNTHETIC COMMUN., vol. 14, 1984, pages 1193
S. B. SINGH ET AL., BIOORG. MED. CHEM., vol. 8, 2000, pages 571
A. M. DESPANDE ET AL., SYNTHESIS, vol. 5, 2001, pages 702
See also references of EP 1941873A4
Attorney, Agent or Firm:
YOSHITAKE, Kenji et al. (Room 323 Fuji Bldg., 2-3, Marunouchi 3-chom, Chiyoda-ku Tokyo, JP)
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