METFORMIN CAFFEIC ACID SALT, METHOD FOR PREPARING SAME, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND COMBINED FORMULATION COMPRISING SAME

Title:

METFORMIN CAFFEIC ACID SALT, METHOD FOR PREPARING SAME, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND COMBINED FORMULATION COMPRISING SAME

Document Type and Number:

WIPO Patent Application WO/2011/025270

Kind Code:

A2

Abstract:

The present invention relates to a metformin caffeic acid salt, to a method for preparing same, to a pharmaceutical composition comprising same, and to a combined formulation comprising same. The metformin caffeic acid salt of the present invention has superior stability, enables easy tabletting, and has low toxicity, thus can be valuably used in the treatment of glycosuria, diabetes, metabolic syndrome, diabetes complications, menstrual irregularities, hypertension, hyperlipidemia, fatty liver, coronary artery disease, osteoporosis, polycystic ovary syndrome, cancer, myalgia, symptoms of muscle cell cytotoxicity, rhabdomyolysis, climacterium, etc., and/or provides antioxidant activity.

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Inventors:

KIM SUNG WUK (KR)
JUN SUNG SOO (KR)
MIN CHANGHEE (KR)
KOO JA SEONG (KR)
KANG MIN SEOK (KR)
KIM YONG EUN (KR)

Application Number:

PCT/KR2010/005712

Publication Date:

March 03, 2011

Filing Date:

August 25, 2010

Export Citation:

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Assignee:

HANALL BIOPHARMA CO LTD (KR)
KIM SUNG WUK (KR)
JUN SUNG SOO (KR)
MIN CHANGHEE (KR)
KOO JA SEONG (KR)
KANG MIN SEOK (KR)
KIM YONG EUN (KR)

International Classes:

C07C279/26; A61K31/155; A61K31/192; C07C59/11

Domestic Patent References:

WO2008112167A1	2008-09-18
WO2005092311A1	2005-10-06

Foreign References:

KR100774774B1

2007-11-07

Other References:

HUANG, N-L ET AL.: 'Metformin inhibits TNF-alpha-induced IkB kinase phosphorylation, IkB-alpha degradation and IL-6 production in endothelialcells through PI3K-dependent AMPK phosphorylation' INTERNATIONAL JOURNAL OF CARDIOLOGY vol. 134, 15 May 2009, pages 169 - 175

Attorney, Agent or Firm:

AHN, So-Young (KR)
안소영 (KR)

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