METHANOL-INDUCIBLE PROMOTER AND USE THEREOF IN PREPARATION OF L-ALANYL-L-GLUTAMINE

Title:

METHANOL-INDUCIBLE PROMOTER AND USE THEREOF IN PREPARATION OF L-ALANYL-L-GLUTAMINE

Document Type and Number:

WIPO Patent Application WO/2023/184539

Kind Code:

A1

Abstract:

Provided are a methanol-inducible promoter and the use thereof in the preparation of L-alanyl-L-glutamine. A nucleotide sequence encoding the methanol-inducible promoter is as shown in SEQ ID NO: 6. Further disclosed is a fusion gene, which comprises the methanol-inducible promoter and amino acid ester acyltransferase, wherein the nucleotide sequence of the amino acid ester acyltransferase is as shown in SEQ ID NO: 25.

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Inventors:

LIN LICHUN (CN)
PI LI (CN)
SUN YUE (CN)
XING PANPAN (CN)
SU HAIXIA (CN)
ZHA LIYAN (CN)
HE JIAJUN (CN)
ZHU YUHAN (CN)
CHEN LEI (CN)
LI XIAOBO (CN)
YE MIAO (CN)
WEI ZIXIANG (CN)

Application Number:

PCT/CN2022/085076

Publication Date:

October 05, 2023

Filing Date:

April 02, 2022

Export Citation:

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Assignee:

WUHAN GRAND HOYO CO LTD (CN)

International Classes:

C12N1/21; C07K5/062

Foreign References:

CN105358706A	2016-02-24
CN108642074A	2018-10-12
CN113549619A	2021-10-26
US6171828B1	2001-01-09

Other References:

HOHENBLUM H, ET AL.: "Effects of Gene Dosage, Promoters, and Substrates on Unfolded Protein Stress of Recombinant Pichia Pastoris", BIOTECHNOLOGY AND BIOENGINEERING, vol. 85, no. 4, 20 February 2004 (2004-02-20), pages 368 - 369, XP009118820, DOI: 10.1002/bit.10904

Attorney, Agent or Firm:

SHANGHAI BESHINING LAW OFFICE (CN)

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