Title:
METHOD FOR ACQUIRING CELL-FREE FETAL DNA CONCENTRATION, ACQUISITION DEVICE, STORAGE MEDIUM, AND ELECTRONIC DEVICE
Document Type and Number:
WIPO Patent Application WO/2020/063052
Kind Code:
A1
Abstract:
Disclosed are a method for acquiring a cell-free fetal DNA concentration, an acquisition device, a storage medium, and an electronic device. The method comprises: acquiring sequencing data of a sample under test, wherein the sample under test is obtained from a pregnant mother; establishing a joint probability distribution model of a maternal and fetal genotype, wherein the joint probability distribution model comprises one or more factors affecting a read heterozygosity level, and the read heterozygosity level is a ratio of the number of SNP sites covered by different bases to the total number of SNP sites in the sequencing data; and substituting values for the one or more factors and the acquired value for the heterozygosity level in the joint probability distribution model, performing maximum likelihood estimation on the joint probability distribution model, and obtaining a cell-free fetal DNA concentration. The method solves the problem of the prior art in which fetal DNA concentration testing has high costs.
Inventors:
GUAN YONGTAO (CN)
XU HANLI (CN)
ZHANG JINGBO (CN)
WANG WEIWEI (CN)
WU QIXI (CN)
FANG NAN (CN)
BAI LING (CN)
WANG JIANWEI (CN)
XU HANLI (CN)
ZHANG JINGBO (CN)
WANG WEIWEI (CN)
WU QIXI (CN)
FANG NAN (CN)
BAI LING (CN)
WANG JIANWEI (CN)
Application Number:
PCT/CN2019/096367
Publication Date:
April 02, 2020
Filing Date:
July 17, 2019
Export Citation:
Assignee:
BEIJING USCI MEDICAL DEVICES CO LTD (CN)
International Classes:
G16B30/00
Foreign References:
| CN109461473A | 2019-03-12 | |||
| CN106591451A | 2017-04-26 | |||
| CN107133491A | 2017-09-05 | |||
| CN104846089A | 2015-08-19 | |||
| US20050192763A1 | 2005-09-01 |
Attorney, Agent or Firm:
KANGXIN PARTNERS, P.C. (CN)
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