Title:
METHOD FOR ADJUSTING EFFECTIVE SIZE OF SOLID-STATE NANOPORE IN SOLID-STATE NANOPORE SYSTEM
Document Type and Number:
WIPO Patent Application WO/2019/109253
Kind Code:
A1
Abstract:
A method for adjusting an effective size of a solid-state nanopore (1) in a solid-state nanopore system. The solid-state nanopore system comprises an electrolyte solution (4), a semiconductor substrate (3), and a voltage assembly (5). The semiconductor substrate (3) is provided with the solid-state nanopores (1), and is disposed in the electrolyte solution (4), icons are adsorbed to wall surfaces of the solid-state nanopores (1) to form a double electric layer (2), and the voltage assembly (5) is electrically connected to the semiconductor substrate (3). The method comprises: applying preset voltages of different voltage values on a semiconductor substrate (3) by means of a voltage assembly (5), so as to obtain effective sizes of solid-state nanopores (1) of different sizes. The method can be reversible, has a high efficiency and low costs, produces no harm, does not affect surface features of the solid-state nanopores (1) due to introduction of a foreign material, and does not have a negative effect on the lengths of the solid-state nanopores (1) and the like, and the form retention of the solid-state nanopores (1) is good; and the method has simple operation steps, saves time and labor and has good controllability, and the adjustment can be automatically implemented in real time.
Inventors:
LIU ZEWEN (CN)
CHEN QI (CN)
WANG YIFAN (CN)
CHEN QI (CN)
WANG YIFAN (CN)
Application Number:
PCT/CN2017/114642
Publication Date:
June 13, 2019
Filing Date:
December 05, 2017
Export Citation:
Assignee:
UNIV TSINGHUA (CN)
International Classes:
B01D67/00; G01N27/413
Domestic Patent References:
| WO2005105272A1 | 2005-11-10 |
Foreign References:
| CN104411386A | 2015-03-11 | |||
| CN201917552U | 2011-08-03 | |||
| CN105573359A | 2016-05-11 | |||
| CN106570297A | 2017-04-19 | |||
| CN102687028A | 2012-09-19 |
Attorney, Agent or Firm:
TSINGYIHUA INTELLECTUAL PROPERTY LLC (CN)
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