Title:
A METHOD OF ADMINISTERING AN ANTITUMOUR COMPOUND USING A POLYMER-CAMPTOTHECIN CONJUGATE
Document Type and Number:
WIPO Patent Application WO2001076597
Kind Code:
A3
Abstract:
Use of MAG-CPT, a polymer-bound conjugate described in WO99/17804, in the manufacture of a medicament for the treatment of a tumour by a dose schedule comprising administration of the said compound by intravenous infusion daily for three consecutive days every 4 weeks in an amount of from 15 to 100 mg/m<2>/day, or weekly for 2 or 3 consecutive weeks every 4 weeks in an amount of from 20 to 250 mg/m<2>/week, or as a single administration every week or every four weeks in an amount of from 20 to 240 mg/m<2>. The method is preferably for the treatment of solid tumours, such as cancer of the gastro-intestinal tract (e.g. colo-rectal, pancreatic, gastric and oesophageal), ovarian, mammary, prostatic, lung, kidney and melanoma.
Inventors:
GERLETTI PAOLA (IT)
PORRO MARIA GRAZIA (IT)
SPEED WILLIAM (IT)
PORRO MARIA GRAZIA (IT)
SPEED WILLIAM (IT)
Application Number:
PCT/EP2001/003765
Publication Date:
May 16, 2002
Filing Date:
April 03, 2001
Export Citation:
Assignee:
PHARMACIA & UPJOHN SPA (IT)
GERLETTI PAOLA (IT)
PORRO MARIA GRAZIA (IT)
SPEED WILLIAM (IT)
GERLETTI PAOLA (IT)
PORRO MARIA GRAZIA (IT)
SPEED WILLIAM (IT)
International Classes:
A61K9/00; A61K31/4745; A61K31/785; A61K47/26; A61K47/48; A61P35/00; A61K9/19; (IPC1-7): A61K31/437; A61K31/47; A61K31/785; A61K47/48; A61P35/00
Domestic Patent References:
| WO1999017805A1 | 1999-04-15 | |||
| WO1999017804A1 | 1999-04-15 | |||
| WO2001000240A2 | 2001-01-04 |
Foreign References:
| US5773522A | 1998-06-30 |
Other References:
CAIOLFA V R ET AL: "Polymer-bound camptothecin: initial biodistribution and antitumour activity studies", JOURNAL OF CONTROLLED RELEASE, ELSEVIER SCIENCE PUBLISHERS B.V., AMSTERDAM, NL, vol. 65, no. 1-2, March 2000 (2000-03-01), pages 105 - 119, XP004190316, ISSN: 0168-3659
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