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Title:
METHOD AND APPARATUS FOR DETECTING PENETRATION DEPTH OF RIBOFLAVIN IN CORNEA
Document Type and Number:
WIPO Patent Application WO/2023/092929
Kind Code:
A8
Abstract:
A method for detecting a penetration depth of riboflavin in a cornea, comprising: acquiring an optical section of RGB colors and converting into an image in a CIEL*a*b* color space, extracting a luminance component L* in the CIEL*a*b* color space, and performing binarization and Blob analysis to obtain an image with a non-cornea region removed therefrom; based on the image with the non-cornea region removed therefrom and a luminance component L* image, extracting boundary points of anterior and posterior corneal surfaces and performing curve fitting, so as to obtain anterior and posterior corneal surface curves; performing image fusion on the anterior and posterior corneal surface curves and the CIEL*a*b* color space to obtain a cornea region-only CIEL*a*b* color image; in the cornea region-only CIEL*a*b* color image, determining a riboflavin-penetrating region, and partitioning the riboflavin-penetrating region into riboflavin-penetrating sites, and performing curve fitting and noise reduction on the riboflavin-penetrating sites to obtain the riboflavin penetration depth and the corneal anterior and posterior surface curves. By means of implementing the present invention, the penetration depth of riboflavin in a cornea can be quantitatively detected in a visual and accurate manner.

Inventors:
ZHOU XINGTAO (CN)
HUANG JINHAI (CN)
WANG CUIZHI (CN)
YAO PEIJUN (CN)
HAN TIAN (CN)
LI MEIYAN (CN)
Application Number:
PCT/CN2022/087001
Publication Date:
November 09, 2023
Filing Date:
April 15, 2022
Export Citation:
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Assignee:
EYE AND EAR NOSE AND THROAT HOSPITAL AFFILIATED TO FUDAN UNIV (CN)
International Classes:
G06T7/00
Attorney, Agent or Firm:
WENZHOU MINGCHUANG INTELLECTUAL PROPERTY AGENCY CO., LTD (CN)
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