Title:
METHOD AND APPARATUS FOR DETECTING PENETRATION DEPTH OF RIBOFLAVIN IN CORNEA
Document Type and Number:
WIPO Patent Application WO/2023/092929
Kind Code:
A8
Abstract:
A method for detecting a penetration depth of riboflavin in a cornea, comprising: acquiring an optical section of RGB colors and converting into an image in a CIEL*a*b* color space, extracting a luminance component L* in the CIEL*a*b* color space, and performing binarization and Blob analysis to obtain an image with a non-cornea region removed therefrom; based on the image with the non-cornea region removed therefrom and a luminance component L* image, extracting boundary points of anterior and posterior corneal surfaces and performing curve fitting, so as to obtain anterior and posterior corneal surface curves; performing image fusion on the anterior and posterior corneal surface curves and the CIEL*a*b* color space to obtain a cornea region-only CIEL*a*b* color image; in the cornea region-only CIEL*a*b* color image, determining a riboflavin-penetrating region, and partitioning the riboflavin-penetrating region into riboflavin-penetrating sites, and performing curve fitting and noise reduction on the riboflavin-penetrating sites to obtain the riboflavin penetration depth and the corneal anterior and posterior surface curves. By means of implementing the present invention, the penetration depth of riboflavin in a cornea can be quantitatively detected in a visual and accurate manner.
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Inventors:
ZHOU XINGTAO (CN)
HUANG JINHAI (CN)
WANG CUIZHI (CN)
YAO PEIJUN (CN)
HAN TIAN (CN)
LI MEIYAN (CN)
HUANG JINHAI (CN)
WANG CUIZHI (CN)
YAO PEIJUN (CN)
HAN TIAN (CN)
LI MEIYAN (CN)
Application Number:
PCT/CN2022/087001
Publication Date:
November 09, 2023
Filing Date:
April 15, 2022
Export Citation:
Assignee:
EYE AND EAR NOSE AND THROAT HOSPITAL AFFILIATED TO FUDAN UNIV (CN)
International Classes:
G06T7/00
Attorney, Agent or Firm:
WENZHOU MINGCHUANG INTELLECTUAL PROPERTY AGENCY CO., LTD (CN)
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