METHOD FOR ASSESSING QUALITY OF VACCINE AND PROTECTION DURATION OF VACCINE

WIPO Patent Application WO/2023/125741

A1

A method for assessing the quality of a vaccine and the protection duration of the vaccine. Body fluids of the human body before and after vaccination are measured by means of MALDI-TOF MS mass spectrometry, and immune response fingerprint spectra consisting of 5-200 mass spectrum peaks are acquired respectively. A model classifier is created on the basis of changes between the spectrum from before an immune response and the spectrum from after the immune response with the combination of a machine learning method, and molecular immune changes of a human serum sample to be measured are analyzed, so as to determine whether the sample is vaccinated and an immune protection effect is generated, thus assessing the quality of the vaccine and/or the protection duration of the vaccine. Meanwhile, changes of various molecular immune responses in the body fluids can be measured. In addition to ensuring high specificity, the accuracy and sensitivity of measurement are effectively increased, experiment operations are simplified, the measurement time is reduced, and measurement costs are reduced.

MA QINGWEI (CN)
XU BIN (CN)
LU QIAN (CN)

PCT/CN2022/143102

July 06, 2023

December 29, 2022

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BEIJING YIXINBOCHUANG BIOTECHNOLOGY CO LTD (CN)

G01N33/68; G01N27/626; G16B5/00; G16B40/10

WO2008157518A1	2008-12-24
WO2021143501A1	2021-07-22

CN111307926A	2020-06-19
CN111007140A	2020-04-14
CN106557667A	2017-04-05
CN108896682A	2018-11-27

MENG, JUN ET AL.: "Construction of Gastric Cardia Adenocarcinoma Diagnostic Model Using MALDI-TOF MS Serum Protein Profiling", CHINA ONCOLOGY, vol. 20, no. 12, 20 December 2010 (2010-12-20), XP009547386

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