Title:
METHOD FOR ASSISTING DIAGNOSIS OF PARKINSON'S DISEASE, BIOMARKER, REAGENT KIT, AND DEVICE
Document Type and Number:
WIPO Patent Application WO/2021/107155
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing: a method for assisting the diagnosis of Parkinson's disease in a simple manner; a biomarker; a reagent kit; and a device. The present invention relates to: a method for assisting the diagnosis of Parkinson's disease, the method comprising measuring the amount of an extracellular vesicle having phosphatidylserine and tetraspanin or both of the amount of an extracellular vesicle having phosphatidylserine and tetraspanin and the amount of an extracellular vesicle having tetraspanin and determining that a subject is affected by Parkinson's disease by employing, as a measure, the amount of the extracellular vesicle having phosphatidylserine and tetraspanin or the ratio of the amount of the extracellular vesicle having phosphatidylserine and tetraspanin to the amount of the extracellular vesicle having tetraspanin; a biomarker; a reagent kit; and a device.
Inventors:
NISHIBU TAKAHIRO (JP)
IMAWAKA NAOKO (JP)
HIRAYASU KAZUNARI (JP)
UKEKAWA RYO (JP)
SASAMOTO KODAI (JP)
ONODERA SATOSHI (JP)
IMAWAKA NAOKO (JP)
HIRAYASU KAZUNARI (JP)
UKEKAWA RYO (JP)
SASAMOTO KODAI (JP)
ONODERA SATOSHI (JP)
Application Number:
PCT/JP2020/044400
Publication Date:
June 03, 2021
Filing Date:
November 27, 2020
Export Citation:
Assignee:
FUJIFILM WAKO PURE CHEMICAL CORP (JP)
FUJIFILM WAKO SHIBAYAGI CORP (JP)
FUJIFILM WAKO SHIBAYAGI CORP (JP)
International Classes:
G01N33/92; C12M1/34; C12Q1/06; G01N33/53; G01N33/68
Domestic Patent References:
| WO2016088689A1 | 2016-06-09 | |||
| WO2017032871A1 | 2017-03-02 | |||
| WO2018145211A1 | 2018-08-16 | |||
| WO2016088689A1 | 2016-06-09 |
Foreign References:
| JP2017525976A | 2017-09-07 | |||
| JP2016161480A | 2016-09-05 | |||
| JP2016550673A | 2014-10-24 | |||
| JP2017520760A | 2017-07-27 |
Other References:
OHMICHI, TAKUMA ET AL.: "Quantification of brain- derived extracellular vesicles in plasma as a biomarker to diagnose Parkinson's diseases", PARKINSONISM AND RELATED DISORDERS, vol. 61, April 2019 (2019-04-01), pages 82 - 87, XP085669225, DOI: 10.1016/j.parkreldis.2018.11.021
MUSTAPIC M ET AL., FRONT. NEUROSCI., vol. 11, 2017, pages 278
NATURE REVIEWS IMMUNOLOGY, vol. 9, August 2009 (2009-08-01), pages 581 - 593
NAOTO AOKI ET AL., STUDY OF OBESITY, vol. 13, no. 2, 2007
"Immunoassay", 2014, KODANSHA LTD.
MUSTAPIC M ET AL., FRONT. NEUROSCI., vol. 11, 2017, pages 278
NATURE REVIEWS IMMUNOLOGY, vol. 9, August 2009 (2009-08-01), pages 581 - 593
NAOTO AOKI ET AL., STUDY OF OBESITY, vol. 13, no. 2, 2007
"Immunoassay", 2014, KODANSHA LTD.
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