Title:
METHOD FOR ASYMMETRIC SYNTHESIS OF CHIRAL CARBOXYLIC ACID COMPOUNDS USING THIOESTER HYDROLASE
Document Type and Number:
WIPO Patent Application WO/2019/026800
Kind Code:
A1
Abstract:
Provided is a method that asymmetrically synthesizes a chiral carboxylic acid, through an enzymatic hydrolysis reaction mediated by at least one acylCoA esterase selected from the group consisting of ACOT7 and ACOT13, from the racemate of a thioester compound having an asymmetric carbon at the α-position and represented by general formula (I).
[In the formula, R1, R2, R3, and R4 represent hydrogen or a substituent. R2 and R3 may form a substituted or unsubstituted cyclic structure together with the carbon atom to which they are bonded. However, R1, R2, R3, and CO-S-R4 are different from each other.]
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Inventors:
NIWA KAZUKI (JP)
GOSHIMA NAOKI (JP)
FUKUDA ERIKO (JP)
KATO DAI-ICHIRO (JP)
GOSHIMA NAOKI (JP)
FUKUDA ERIKO (JP)
KATO DAI-ICHIRO (JP)
Application Number:
PCT/JP2018/028295
Publication Date:
February 07, 2019
Filing Date:
July 27, 2018
Export Citation:
Assignee:
AIST (JP)
International Classes:
C12P41/00; C12N9/18
Foreign References:
| JP2006180825A | 2006-07-13 |
Other References:
DATABASE Database DDBJ/EMBL/GenBank [online] 25 June 2017 (2017-06-25), Database accession no. NP_009205
DATABASE Database DDBJ/EMBL/GenBank [online] 16 September 2016 (2016-09-16), Database accession no. NP_060943
KATO, D. ET AL.: "Comparison of Acyl-CoA Synthetic Activities and Enantioselectivity toward 2-Arylpropanoic Acids in Firefly Luciferases", BIOSCIENCE, BIOTECHNOLOGY, AND BIOCHEMISTRY, vol. 75, no. 9, 2011, pages 1758 - 1762, XP055678585
KATO DAIICHIRO: "Method for utilizing firefly luciferase as material production means", CHEMISTRY AND CHEMICAL INDUSTRY, vol. 65, no. 3, 1 January 2012 (2012-01-01), pages 225 - 226
DATABASE Database DDBJ/EMBL/GenBank [online] 16 September 2016 (2016-09-16), Database accession no. NP_060943
KATO, D. ET AL.: "Comparison of Acyl-CoA Synthetic Activities and Enantioselectivity toward 2-Arylpropanoic Acids in Firefly Luciferases", BIOSCIENCE, BIOTECHNOLOGY, AND BIOCHEMISTRY, vol. 75, no. 9, 2011, pages 1758 - 1762, XP055678585
KATO DAIICHIRO: "Method for utilizing firefly luciferase as material production means", CHEMISTRY AND CHEMICAL INDUSTRY, vol. 65, no. 3, 1 January 2012 (2012-01-01), pages 225 - 226
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
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