Title:
METHOD FOR BIOCATALYTIC SYNTHESIS OF SITAGLIPTIN AND INTERMEDIATE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/214084
Kind Code:
A1
Abstract:
Provided is a method for biocatalytic synthesis of Sitagliptin and intermediates thereof, in particular, provided are compounds of Formula (I) and Formula (II), or pharmaceutically acceptable salts thereof, a polypeptide capable of catalyzing conversion of a compound of Formula (I) to a compound of Formula (II), a nucleic acid encoding the polypeptide, a vector and a cell comprising the nucleic acid. In addition, also provided are a method for producing a compound of Formula (II) and Sitagliptin by using the polypeptide and the compound of Formula (I), and a method for preparing the polypeptide.
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Inventors:
WU FAHAO (CN)
YANG WEN (CN)
LI GANG (CN)
SHI HONGWEI (CN)
GAO YANGZHE (CN)
LIU LILI (CN)
YUAN ZHIFA (CN)
YANG WEN (CN)
LI GANG (CN)
SHI HONGWEI (CN)
GAO YANGZHE (CN)
LIU LILI (CN)
YUAN ZHIFA (CN)
Application Number:
PCT/CN2018/097354
Publication Date:
November 14, 2019
Filing Date:
July 27, 2018
Export Citation:
Assignee:
CHINA SINOPHARM INT CORPORATION (CN)
NANJING REDWOOD FINE CHEMICAL CO LTD (CN)
NANJING REDWOOD FINE CHEMICAL CO LTD (CN)
International Classes:
C07D233/56; C07D295/182; C12N9/10; C12N15/54; C12P13/00
Domestic Patent References:
| WO2011135586A2 | 2011-11-03 |
Foreign References:
| CN105294479A | 2016-02-03 | |||
| CN102405281A | 2012-04-04 | |||
| CN102597226A | 2012-07-18 | |||
| CN107286164A | 2017-10-24 | |||
| CN102277322A | 2011-12-14 | |||
| CN102702205A | 2012-10-03 |
Other References:
XU, FENG ET AL.: "Mechanistic Evidence for an a-Oxoketene Pathway in the Formation of beta- Ketoamides/Esters via Meldrum's Acid Adducts", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 126, no. 40, 16 September 2004 (2004-09-16), pages 13002 - 13009, XP055650906, ISSN: 0002-7863
DATABASE REGISTRY CAS; 31 October 2017 (2017-10-31), retrieved from STN Database accession no. RN2137101-64-3
DATABASE REGISTRY CAS; 31 October 2017 (2017-10-31), retrieved from STN Database accession no. RN2137101-64-3
Attorney, Agent or Firm:
CCPIT PATENT AND TRADEMARK LAW OFFICE (CN)
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