Title:
METHOD FOR CHANGING HYDROGEL VOLUME AND HYDROGEL
Document Type and Number:
WIPO Patent Application WO/2023/127503
Kind Code:
A1
Abstract:
This invention relates to a method for changing hydrogel volume, the method comprising: a step A for bringing an ionic polymer into contact with a hydrogel, which has a site having decomposition activity for the ionic polymer and a cross-linking functional group that is capable of cross-linking with the ionic polymer through electrostatic interaction, to allow the cross-linking functional group to cross-link with the ionic polymer, and reducing the volume of the hydrogel; and a step B for decomposing the ionic polymer cross-linking with the hydrogel using the site having decomposition activity and discharging at least part of the ionic polymer decomposition product from the hydrogel so as to increase the volume of the hydrogel.
Inventors:
MATSUSAKI MICHIYA (JP)
NAKAMOTO MASAHIKO (JP)
KITANO SHIRO (JP)
NAKAMOTO MASAHIKO (JP)
KITANO SHIRO (JP)
Application Number:
PCT/JP2022/046100
Publication Date:
July 06, 2023
Filing Date:
December 14, 2022
Export Citation:
Assignee:
TOPPAN INC (JP)
UNIV OSAKA (JP)
UNIV OSAKA (JP)
International Classes:
C07K2/00; A61K9/06; A61K47/42; C12N11/04
Foreign References:
| US20170158836A1 | 2017-06-08 | |||
| JP2005304212A | 2005-10-27 |
Other References:
HE HONGKUN, AVERICK SAADYAH, MANDAL PRATITI, DING HANGJUN, LI SIPEI, GELB JEFF, KOTWAL NAOMI, MERKLE ARNO, LITSTER SHAWN, MATYJASZ: "Multifunctional Hydrogels with Reversible 3D Ordered Macroporous Structures", ADVANCED SCIENCE, vol. 2, no. 5, 1 May 2015 (2015-05-01), pages 1500069, XP093076309, ISSN: 2198-3844, DOI: 10.1002/advs.201500069
HOSHINO YU, JIBIKI TOSHIKI, NAKAMOTO MASAHIKO, MIURA YOSHIKO: "Reversible p K a Modulation of Carboxylic Acids in Temperature-Responsive Nanoparticles through Imprinted Electrostatic Interactions", APPLIED MATERIALS & INTERFACES, AMERICAN CHEMICAL SOCIETY, US, vol. 10, no. 37, 19 September 2018 (2018-09-19), US , pages 31096 - 31105, XP093076310, ISSN: 1944-8244, DOI: 10.1021/acsami.8b11397
LABIE HELENE; PERRO ADELINE; LAPEYRE VERONIQUE; GOUDEAU BERTRAND; CATARGI BOGDAN; AUZELY RACHEL; RAVAINE VALERIE: "Sealing hyaluronic acid microgels with oppositely-charged polypeptides: A simple strategy for packaging hydrophilic drugs with on-demand release", JOURNAL OF COLLOID AND INTERFACE SCIENCE, ACADEMIC PRESS,INC., US, vol. 535, 15 September 2018 (2018-09-15), US , pages 16 - 27, XP085537906, ISSN: 0021-9797, DOI: 10.1016/j.jcis.2018.09.048
NAKAMOTO MASAHIKO, KITANO SHIRO, MATSUSAKI MICHIYA: "BiomacromoleculeâFueled Transient Volume Phase Transition of a Hydrogel", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, VERLAG CHEMIE, HOBOKEN, USA, vol. 61, no. 33, 15 August 2022 (2022-08-15), Hoboken, USA, XP093076312, ISSN: 1433-7851, DOI: 10.1002/anie.202205125
HOSHINO YU, JIBIKI TOSHIKI, NAKAMOTO MASAHIKO, MIURA YOSHIKO: "Reversible p K a Modulation of Carboxylic Acids in Temperature-Responsive Nanoparticles through Imprinted Electrostatic Interactions", APPLIED MATERIALS & INTERFACES, AMERICAN CHEMICAL SOCIETY, US, vol. 10, no. 37, 19 September 2018 (2018-09-19), US , pages 31096 - 31105, XP093076310, ISSN: 1944-8244, DOI: 10.1021/acsami.8b11397
LABIE HELENE; PERRO ADELINE; LAPEYRE VERONIQUE; GOUDEAU BERTRAND; CATARGI BOGDAN; AUZELY RACHEL; RAVAINE VALERIE: "Sealing hyaluronic acid microgels with oppositely-charged polypeptides: A simple strategy for packaging hydrophilic drugs with on-demand release", JOURNAL OF COLLOID AND INTERFACE SCIENCE, ACADEMIC PRESS,INC., US, vol. 535, 15 September 2018 (2018-09-15), US , pages 16 - 27, XP085537906, ISSN: 0021-9797, DOI: 10.1016/j.jcis.2018.09.048
NAKAMOTO MASAHIKO, KITANO SHIRO, MATSUSAKI MICHIYA: "BiomacromoleculeâFueled Transient Volume Phase Transition of a Hydrogel", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, VERLAG CHEMIE, HOBOKEN, USA, vol. 61, no. 33, 15 August 2022 (2022-08-15), Hoboken, USA, XP093076312, ISSN: 1433-7851, DOI: 10.1002/anie.202205125
Attorney, Agent or Firm:
HASEGAWA Yoshiki et al. (JP)
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