Title:
METHOD AND COMPOSITIONS FOR INHIBITING PROTEIN KINMETHOD AND COMPOSITIONS FOR INHIBITING PROTEIN KINASES ASES
Document Type and Number:
WIPO Patent Application WO1996013259
Kind Code:
A3
Abstract:
A method for selectively inhibiting a kinase is disclosed, which comprises contacting a composition containing a kinase with a molecule of the formular alkanoyl; R2 is H, lower alkyl, or lower alkanoyl; R3 and R4 together represent a cis double bond or -O- or each of R3 and R4 independently represents H or OR; R5 is =O, =S, or -H, -OR; R6 and R7 together represent a double bond or -O- or each of R6 and R7 independently represents H or OR; R4 and R together represent a double bond or -O- or each of R8 and R9 independently represents H or OR; and each R independently represents H, lower alkyl, or lower alkanoyl.
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Inventors:
GIESE NEILL A
LOKKER NATHALIE
LOKKER NATHALIE
Application Number:
PCT/US1995/013882
Publication Date:
August 01, 1996
Filing Date:
October 26, 1995
Export Citation:
Assignee:
COR THERAPEUTICS INC (US)
International Classes:
A61K31/365; C12N9/99; A61K31/366; A61P35/02; C07D313/00; (IPC1-7): A61K31/365
Foreign References:
| EP0251813A2 | 1988-01-07 |
Other References:
J. CHUNG ET AL.: "Rapamycin-FKBP specifically blocks growth-dependent activation of and signalling by the 70kd S6 protein kinases.", CELL, vol. 69, no. 7, 1992, pages 1227 - 1236, XP000567055
R.G. ARORA ET AL.: "Inhibition of ochratoxin A teratogenesis by zearalenone and diethylstilbestrol.", FOOD CHEM. TOXICOL., vol. 21, no. 6, 1983, pages 779 - 783, XP000568648
R. THUST ET AL.: "Genotoxicity of Fusarium mycotoxins (nivalenol, fusarenon-x, t-2 toxin and zearalenone) in chinese hamster V79-E cells in vitro.", ARCH. GESCHWULSTFORSCH., vol. 53, no. 1, 1983, pages 9 - 15, XP000568651
D.T. ZAVA ET AL.: "Effects of plant and fungal estrogens on E-sensitive human breast cancer cells.", PROC. ANNU. MEET. AM. ASSOC. CANCER RES., vol. 35, 1994, pages 88, XP002001543
R.G. ARORA ET AL.: "Inhibition of ochratoxin A teratogenesis by zearalenone and diethylstilbestrol.", FOOD CHEM. TOXICOL., vol. 21, no. 6, 1983, pages 779 - 783, XP000568648
R. THUST ET AL.: "Genotoxicity of Fusarium mycotoxins (nivalenol, fusarenon-x, t-2 toxin and zearalenone) in chinese hamster V79-E cells in vitro.", ARCH. GESCHWULSTFORSCH., vol. 53, no. 1, 1983, pages 9 - 15, XP000568651
D.T. ZAVA ET AL.: "Effects of plant and fungal estrogens on E-sensitive human breast cancer cells.", PROC. ANNU. MEET. AM. ASSOC. CANCER RES., vol. 35, 1994, pages 88, XP002001543
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