Title:
METHOD FOR CONSTRUCTING ANIMAL MODEL OF LUNG CANCER
Document Type and Number:
WIPO Patent Application WO/2021/164042
Kind Code:
A1
Abstract:
Provided in the present application is a method for constructing an animal model of lung cancer. The method comprises atomizing lung cancer pathogenic substances into atomized particles, and causing the animals to inhale the atomized particles by means of inhaling to construct a desired animal model of lung cancer. By means of the method, standardized animal models of lung cancer that simulate the origin of lung cancer cells and the various stages and types of lung cancer during the development thereof can be constructed as needed by means of selecting atomized drugs, drug atomization particle size and the concentration of drugs, and animals, etc.
Inventors:
LI MENGFENG (CN)
SUN YAN (CN)
WU JUEHENG (CN)
CAI JUNCHAO (CN)
SUN YAN (CN)
WU JUEHENG (CN)
CAI JUNCHAO (CN)
Application Number:
PCT/CN2020/076640
Publication Date:
August 26, 2021
Filing Date:
February 25, 2020
Export Citation:
Assignee:
UNIV SUN YAT SEN (CN)
International Classes:
A01K67/027; C12N15/861
Other References:
HO-YOUNG LEE, LEE JANET I, HASSAN KHALED A, MAO LI, FORCE THOMAS, GILBERT BRIAN E, JACKS TYLER, KURIE JONATHAN M: "Inhibition of Oncogenic K-ras Signaling by Aerosolized Gene Delivery in a Mouse Model of Human Lung Cancer 1", CLINICAL CANCER RESEARCH, vol. 8, 17 September 2002 (2002-09-17), pages 2907 - 2975, XP055838745
HO-YOUNG LEE, YOUNG-AH SUH, JANET I. LEE, KHALED A. HASSAN, LI MAO, THOMAS FORCE, BRIAN E. GILBERT, TYLER JACKS, JONATHAN M. KURIE: "Inhibition of Oncogenic K-ras Signaling by Aerosolized Gene Delivery in a Mouse Model of Human Lung Cancer 1", CLINICAL CANCER RESEARCH, vol. 8, 1 September 2002 (2002-09-01), pages 2971 - 2975, XP055838772
JACKSON E.L. ET AL.: "Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras", GENES ＆ DEVELOPMENT, vol. 15, no. 24, 31 December 2001 (2001-12-31), XP002584752, ISSN: 0890-9369
张修彦 等 (ZHANG, XIUYAN ET AL.): "肺腺瘤小鼠模型的建立及其血生化, 血常规, 尿常规, 病理检测 (Establishment of a mouse model of pulmonary adenoma and its routine examination of blood and urine, blood biochemistry and pathology)", 中国比较医学杂志 (CHINESE JOURNAL OF COMPARATIVE MEDICINE), vol. 28, no. 11, 30 November 2018 (2018-11-30), ISSN: 1671-7856
DUPAGE MICHEL, DOOLEY ALISON L, JACKS TYLER: "Conditional mouse lung cancer models using adenoviral or lentiviral delivery of Cre recombinase", NATURE PROTOCOLS, NATURE PUBLISHING GROUP, GB, vol. 4, no. 7, 1 July 2009 (2009-07-01), GB, pages 1064 - 1072, XP055838787, ISSN: 1754-2189, DOI: 10.1038/nprot.2009.95
HAMMOUD Z., TAN B., BADVE S., BIGSBY R. M: "Estrogen promotes tumor progression in a genetically defined mouse model of lung adenocarcinoma", ENDOCRINE RELATED CANCER, PUBLISHED FOR THE SOCIETY OF ENDOCRINOLOGY BY THE JOURNAL OF ENDOCRINOLOGY LTD., vol. 15, no. 2, 1 June 2008 (2008-06-01), pages 475 - 483, XP055838789, ISSN: 1351-0088, DOI: 10.1677/ERC-08-0002
HO-YOUNG LEE, YOUNG-AH SUH, JANET I. LEE, KHALED A. HASSAN, LI MAO, THOMAS FORCE, BRIAN E. GILBERT, TYLER JACKS, JONATHAN M. KURIE: "Inhibition of Oncogenic K-ras Signaling by Aerosolized Gene Delivery in a Mouse Model of Human Lung Cancer 1", CLINICAL CANCER RESEARCH, vol. 8, 1 September 2002 (2002-09-01), pages 2971 - 2975, XP055838772
JACKSON E.L. ET AL.: "Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras", GENES ＆ DEVELOPMENT, vol. 15, no. 24, 31 December 2001 (2001-12-31), XP002584752, ISSN: 0890-9369
张修彦 等 (ZHANG, XIUYAN ET AL.): "肺腺瘤小鼠模型的建立及其血生化, 血常规, 尿常规, 病理检测 (Establishment of a mouse model of pulmonary adenoma and its routine examination of blood and urine, blood biochemistry and pathology)", 中国比较医学杂志 (CHINESE JOURNAL OF COMPARATIVE MEDICINE), vol. 28, no. 11, 30 November 2018 (2018-11-30), ISSN: 1671-7856
DUPAGE MICHEL, DOOLEY ALISON L, JACKS TYLER: "Conditional mouse lung cancer models using adenoviral or lentiviral delivery of Cre recombinase", NATURE PROTOCOLS, NATURE PUBLISHING GROUP, GB, vol. 4, no. 7, 1 July 2009 (2009-07-01), GB, pages 1064 - 1072, XP055838787, ISSN: 1754-2189, DOI: 10.1038/nprot.2009.95
HAMMOUD Z., TAN B., BADVE S., BIGSBY R. M: "Estrogen promotes tumor progression in a genetically defined mouse model of lung adenocarcinoma", ENDOCRINE RELATED CANCER, PUBLISHED FOR THE SOCIETY OF ENDOCRINOLOGY BY THE JOURNAL OF ENDOCRINOLOGY LTD., vol. 15, no. 2, 1 June 2008 (2008-06-01), pages 475 - 483, XP055838789, ISSN: 1351-0088, DOI: 10.1677/ERC-08-0002
Attorney, Agent or Firm:
YOGO PATENT AND TRADEMARK AGENCY LIMITED COMPANY (CN)
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