Title:
METHOD OF CONTROLLING CELL PROLIFERATION BY USING NOVEL FUNCTION OF MYELOID LEUKEMIA FACTOR MLF1 AND UTILIZATION OF THE SAME
Document Type and Number:
WIPO Patent Application WO/2004/104200
Kind Code:
A1
Abstract:
It is clarified that a myeloid leukemia factor MLF1 has a potent ability to regulate cell proliferation. Using this function, the expression dose of the MLF1 protein is altered or the function of the expressed MLF1 protein is controlled in cells the proliferation of which is to be controlled. More specifically speaking, to regulate the cell proliferation, the expression dose of the MLF1 protein in the cells is elevated. To promote the cell proliferation, the expression dose of the MLF1 protein in the cells is lowered or the function of the above-described MLF1 protein expressed in the cells is regulated or inhibited. This method is applicable in various fields such as drug discovery, medical treatments and studies.
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Inventors:
KATO NORIKO (JP)
KATO JUN-YA (JP)
KATO JUN-YA (JP)
Application Number:
PCT/JP2003/014868
Publication Date:
December 02, 2004
Filing Date:
November 21, 2003
Export Citation:
Assignee:
JAPAN SCIENCE & TECH AGENCY (JP)
KATO NORIKO (JP)
KATO JUN-YA (JP)
KATO NORIKO (JP)
KATO JUN-YA (JP)
International Classes:
A01K67/027; A61K38/00; A61K38/17; A61K45/00; A61K48/00; A61P35/00; C07K14/47; C12N5/10; C12N15/09; C12N15/12; G01N33/50; (IPC1-7): C12N15/12; A61K38/00; A61P35/00; G01N33/50
Other References:
UMEHARA M. et al., "Leukemia-assocaited factor MLF1 regulates the cell cycle through the JAB1/COP9 signalosome.," The 25th annual meeting of the molecular biology society of Japan, Program ans Abstracts, Pacifico Yokohama, December 11-14, 2002, page 825, 2P-0761
YONEDA-KATO N, et al.," Apoptosis induced by the myelodysplastic syndrome-associated NPM-MLF1 chimeric protein.," Oncogene 1999, Vol. 18, No. 25, pages 3716 - 3724
Database Medline, ACC. 11021751, MATSUMOTO N, et al.," Elevated MLF1 expression correlates with malignant progression from myelodysplastic syndrome,." & Leukemia 2000, Vol. 14, No. 10, pages 1757 - 1765
Database BIOSIS on DIALOG, ACC. No. 200300357054, LIM R. et al., Myeloid leukemia factor 1 associates with 14-3-3zeta and a novel adaptor madm. & Blood 2002, Nov., Vol. 100, No. 11, Abstract No. 2920
Database BIOSIS on DIALOG, ACC No. 20000046945, YONEDA-KATO et al., NPM-MLF1 fusion protein downregulates p27skip1 through the novel Jab-mediated pathway., & Blood 1999, Vol. 94, No. 10, Suppl. 1, Part 1, page 484a
OHNO K. et al., "Characterization of a Drosophila homologue of the human myelodysplasia/myeloid leukemia factor (MLF).," Gene 2000, Vol. 260, No. 1-2, Pages 133 - 143
YONEDA-KATO N, et al.," Apoptosis induced by the myelodysplastic syndrome-associated NPM-MLF1 chimeric protein.," Oncogene 1999, Vol. 18, No. 25, pages 3716 - 3724
Database Medline, ACC. 11021751, MATSUMOTO N, et al.," Elevated MLF1 expression correlates with malignant progression from myelodysplastic syndrome,." & Leukemia 2000, Vol. 14, No. 10, pages 1757 - 1765
Database BIOSIS on DIALOG, ACC. No. 200300357054, LIM R. et al., Myeloid leukemia factor 1 associates with 14-3-3zeta and a novel adaptor madm. & Blood 2002, Nov., Vol. 100, No. 11, Abstract No. 2920
Database BIOSIS on DIALOG, ACC No. 20000046945, YONEDA-KATO et al., NPM-MLF1 fusion protein downregulates p27skip1 through the novel Jab-mediated pathway., & Blood 1999, Vol. 94, No. 10, Suppl. 1, Part 1, page 484a
OHNO K. et al., "Characterization of a Drosophila homologue of the human myelodysplasia/myeloid leukemia factor (MLF).," Gene 2000, Vol. 260, No. 1-2, Pages 133 - 143
Attorney, Agent or Firm:
Hara, Kenzo (Daiwa Minamimorimachi Building 2-6,
Tenjinbashi 2-chome Kita, Kita-k, Osaka-shi Osaka, JP)
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