METHOD FOR CONTROLLING THE CHAPERONE ACTIVITY OF PEROXIREDOXINS USING IRRADIATION

WIPO Patent Application WO/2012/057508

A2

The present invention relates to a method for increasing chaperone activity by irradiating peroxiredoxin (Prx) proteins. More particularly, the present invention may be useful for preparing recombinant proteins imparting resistance against various environmental stresses by increasing the chaperone activity of peroxiredoxin, since it has been observed that irradiated peroxiredoxin has enhanced chaperone activity characteristics, wherein an α-helix structure decreases while a β-sheet structure increases, from analysis results of a protein structure change and chaperone activity after irradiating two types of peroxiredoxins (2-Cys, 3-Cys) which are two active cysteine motifs of peroxiredoxin.

CHUNG BYUNG YEOUP (KR)
LEE SEUNG SIK (KR)
AN BYUNG CHULL (KR)
LEE EUN MI (KR)
LEE JAE TAEK (KR)
BAI HYOUNG-WOO (KR)

PCT/KR2011/007998

May 03, 2012

October 25, 2011

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KOREA ATOMIC ENERGY RES (KR)
CHUNG BYUNG YEOUP (KR)
LEE SEUNG SIK (KR)
AN BYUNG CHULL (KR)
LEE EUN MI (KR)
LEE JAE TAEK (KR)
BAI HYOUNG-WOO (KR)

C07K1/107; A01N65/00; C07K14/415

JANG, H. H. ET AL. FEBS LETTERS vol. 580, 2006, pages 351 - 355
JHANG, B. ET AL. WORLD J. GASTROENTEROL. vol. 9, no. 12, 2003, pages 2726 - 2731
LEE, K. ET AL. BIOCHEM. BIOPHYS. RES. COMMUN. vol. 296, 2002, pages 337 - 342

LEE, Won Hee (642-16Yoksam-dong,Kangnam-ku, Seoul 135-080, KR)

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