Title:
METHOD FOR CONTROLLING GENESIS AND/OR DIFFERENTIATION OF EMBRYO
Document Type and Number:
WIPO Patent Application WO/2012/117968
Kind Code:
A1
Abstract:
The problem addressed by the present invention is to provide a method for controlling the genesis and/or differentiation of an embryo by easily and rapidly controlling the obstruction of activation of the Wnt signal without using a genetic engineering method. As a solution, the present invention is a method for controlling the genesis and/or differentiation of an embryo by combining a first effect and another effect on a fertilized egg in vitro using a low-molecular weight organic compound having an effect activating the Wnt signal and a low-molecular weight organic compound having an effect obstructing the Wnt signal. A representative compound of the low-molecular weight organic compound having an effect obstructing the Wnt signal is methyl 2-hydroxy-3,6-dimethyl-4-(3-phenylpropioloyloxy) benzoate.
Inventors:
NISHIYA NAOYUKI (JP)
KAWANO TOMIKAZU (JP)
HATANAKA MINORU (JP)
UEHARA YOSHIMASA (JP)
KAWANO TOMIKAZU (JP)
HATANAKA MINORU (JP)
UEHARA YOSHIMASA (JP)
Application Number:
PCT/JP2012/054585
Publication Date:
September 07, 2012
Filing Date:
February 24, 2012
Export Citation:
Assignee:
IWATE MEDICAL UNIVERSITY (JP)
NISHIYA NAOYUKI (JP)
KAWANO TOMIKAZU (JP)
HATANAKA MINORU (JP)
UEHARA YOSHIMASA (JP)
NISHIYA NAOYUKI (JP)
KAWANO TOMIKAZU (JP)
HATANAKA MINORU (JP)
UEHARA YOSHIMASA (JP)
International Classes:
C12N5/073; C07C65/105; C07C65/19; C07C65/28
Other References:
LIU J ET AL.: "A small-molecule agonist of the Wnt signaling pathway.", ANGEW. CHEM. INT. ED., vol. 44, 2005, pages 1987 - 1990
ZHONG H ET AL.: "Characterization and development of novel small-molecules inhibiting GSK3 and activating Wnt signaling.", MOL. BIOSYST., vol. 5, 2009, pages 1356 - 1360
CHEN W ET AL.: "Development of small molecules targeting the Wnt pathway for the treatment of colon cancer: a high-throughput screening approach.", AM. J. PHYSIOL., vol. 299, 2010, pages G293 - G300
MEIJER L ET AL.: "GSK-3-selective inhibitors derived from tyrian purple indirubins.", CHEM. BIOL., vol. 10, 2003, pages 1255 - 1266
DATABASE DATABASE 2008, "2-hydroxy-4-[(1-oxo-3-phenyl-2-propyn-1-yl) amino] benzoic acid,", Database accession no. 1017053-12-1
ZHONG H ET AL.: "Characterization and development of novel small-molecules inhibiting GSK3 and activating Wnt signaling.", MOL. BIOSYST., vol. 5, 2009, pages 1356 - 1360
CHEN W ET AL.: "Development of small molecules targeting the Wnt pathway for the treatment of colon cancer: a high-throughput screening approach.", AM. J. PHYSIOL., vol. 299, 2010, pages G293 - G300
MEIJER L ET AL.: "GSK-3-selective inhibitors derived from tyrian purple indirubins.", CHEM. BIOL., vol. 10, 2003, pages 1255 - 1266
DATABASE DATABASE 2008, "2-hydroxy-4-[(1-oxo-3-phenyl-2-propyn-1-yl) amino] benzoic acid,", Database accession no. 1017053-12-1
Attorney, Agent or Firm:
TSUJITA Takashi et al. (JP)
Yukifumi Tsujita (JP)
Yukifumi Tsujita (JP)
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