METHOD FOR CONTROLLING MEMBRANE POTENTIAL-DEPENDENT ION CHANNEL THROUGH TYPE I TASTE RECEPTORS (T1RS)

WIPO Patent Application WO/2023/238955

A1

The present invention pertains to a method for controlling a membrane potential-dependent ion channel (VGSC or the like) through a type I taste receptor present in a nerve cell or the like.　In the present invention, it has been found that an Aβ peptide, or a sweet amino acid or an umami substance specifically binds to a type I taste receptor on the surface of a nerve cell to exert an agonist-like or antagonist-like action, thereby amplifying or suppressing a VGSC active current.　Moreover, with the binding of an Aβ peptide or the like to a type I taste receptor, the amplification of a VGSC active current occurs, the overactivity of nerve cells causing epileptiform attack occurs, and a large number of substances, which can effectively suppress the amplification of the VGSC active current, among ligand substances that specifically bind to the type I taste receptor, can be found.　The present invention provides: a type I taste receptor-specific ligand substance that can control the amplification or suppression of a VGSC active current; and a pharmaceutical composition for preventing or treating various neurodegenerative diseases, such as Alzheimer's disease (AD), due to the amplification of a VGSC active current caused by the binding of an Aβ peptide or the like to a type I taste receptor. Moreover, a method for using, as a target receptor, a type I taste receptor present in a nerve cell or the like to screen a ligand substance for controlling a VGSC or the like in the cell is also provided.　Furthermore, the present invention provides a method in which a solution that reproduces the type and concentration of an Aβ peptide contained in the cerebrospinal fluid and serum of a patient with Alzheimer-type dementia is used, and the Aβ peptide contained in the CFS and serum of the patient assesses pathology. Specifically, provided is: a method for assessing the form and dynamic state of cells and the activity of a neurite by using an optical microscope; or a method for assessing the impedance change in a vascular epithelial cell.

SAITO MITSUYOSHI (JP)
SAITO MARIKO (JP)

PCT/JP2023/021634

December 14, 2023

June 09, 2023

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ION CHAT RES CORPORATE (JP)
SAITO MITSUYOSHI (JP)

A61K31/192; A61K45/00; A61K31/198; A61K31/216; A61K31/428; A61K31/70; A61K31/7004; A61K31/7016; A61K31/7076; A61K31/708; A61K38/05; A61K39/395; A61P9/00; A61P21/02; A61P25/00; A61P25/04; A61P25/08; A61P25/14; A61P25/16; A61P25/28; A61P43/00; C07K16/28; C12Q1/02; G01N33/15

JP2005505262A

2005-02-24

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SAEKI, Takuro et al. (JP)

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