Title:
METHOD FOR CONTROLLING STIFFNESS OF DNA ORIGAMI STRUCTURE
Document Type and Number:
WIPO Patent Application WO/2020/209392
Kind Code:
A1
Abstract:
The present invention relates to a method for controlling only stiffness of a DNA origami structure with no cross-sectional shape variations occurring in the structure. The present invention enjoys the advantage of finely overcoming the shortcoming of the conventional technique that most of staple DNA sets should be changed or an entirety of staple DNA sets should be reconstituted in a structure fabricated by the conventional DNA origami technique when cross-section shapes or arrangement patterns of DNA strands are modified in order to change stiffness in a part or the entirety of the structure.
Inventors:
KIM DO NYUN (KR)
LEE CHAN SEOK (KR)
KIM KYUNG SOO (KR)
LEE CHAN SEOK (KR)
KIM KYUNG SOO (KR)
Application Number:
PCT/KR2019/004124
Publication Date:
October 15, 2020
Filing Date:
April 08, 2019
Export Citation:
Assignee:
SEOUL NAT UNIV R&DB FOUNDATION (KR)
International Classes:
C12Q1/6825; C07H21/04; C12Q1/6869
Foreign References:
| KR20180108125A | 2018-10-04 |
Other References:
KIM, GYEONGSU ET AL.: "Stiffness Control for DNA Nanotube through Motif Batch of DNA gap", 2018 THE KOREAN SOCIETY OF MECHANICAL ENGINEER (KSME) CAE AND APPLIED MECHANICS DIVISION SPRING CONFERENCE, 27 April 2018 (2018-04-27), pages 1 - 2
KIM, K. S. ET AL.: "Controlling the flexibility of DNA nanostructures via gap design", FNANO18, 16 April 2018 (2018-04-16)
LEE, CHANSEOK ET AL.: "Efficient Shape Design of DNA Origami Nanostructures through Local Stiffness Control", 2017 THE KOREAN SOCIETY OF MECHANICAL ENGINEER (KSME) CONFERENCCE, November 2017 (2017-11-01), pages 1648 - 1649
LEE, J. Y. ET AL.: "Investigating the sequence-dependent mechanical properties of DNA nicks for applications in twisted DNA nanostructure design", NUCLEIC ACIDS RESEARCH, vol. 47, no. 1, pages 93 - 102, XP055747846, [retrieved on 20181122]
LEE, C. ET AL.: "Polymorphic design of DNA origami structures through mechanical control of modular components", NATURE COMMUNICATIONS, vol. 8, pages 1 - 8, XP055747849, [retrieved on 20171212]
ZHOU, L. ET AL.: "DNA origami compliant nanostructures with tunable mechanical properties", ACS NANO, vol. 8, no. 1, 2014, pages 27 - 34, XP055747851
KIM, DO-NYUN ET AL.: "DNA Origami Nano Technology", JOURNAL OF THE KSME, vol. 56, no. 5, May 2016 (2016-05-01), pages 39 - 42
KIM, K. S. ET AL.: "Controlling the flexibility of DNA nanostructures via gap design", FNANO18, 16 April 2018 (2018-04-16)
LEE, CHANSEOK ET AL.: "Efficient Shape Design of DNA Origami Nanostructures through Local Stiffness Control", 2017 THE KOREAN SOCIETY OF MECHANICAL ENGINEER (KSME) CONFERENCCE, November 2017 (2017-11-01), pages 1648 - 1649
LEE, J. Y. ET AL.: "Investigating the sequence-dependent mechanical properties of DNA nicks for applications in twisted DNA nanostructure design", NUCLEIC ACIDS RESEARCH, vol. 47, no. 1, pages 93 - 102, XP055747846, [retrieved on 20181122]
LEE, C. ET AL.: "Polymorphic design of DNA origami structures through mechanical control of modular components", NATURE COMMUNICATIONS, vol. 8, pages 1 - 8, XP055747849, [retrieved on 20171212]
ZHOU, L. ET AL.: "DNA origami compliant nanostructures with tunable mechanical properties", ACS NANO, vol. 8, no. 1, 2014, pages 27 - 34, XP055747851
KIM, DO-NYUN ET AL.: "DNA Origami Nano Technology", JOURNAL OF THE KSME, vol. 56, no. 5, May 2016 (2016-05-01), pages 39 - 42
Attorney, Agent or Firm:
LEECHAE INTELLECTUAL PROPERTY (KR)
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