Title:
METHOD FOR DESALTING AND PURIFYING 1,3-PROPANEDIOL FERMENTATION BROTH
Document Type and Number:
WIPO Patent Application WO/2023/109027
Kind Code:
A1
Abstract:
Disclosed is a method for desalting and purifying a 1,3-propanediol fermentation broth. The method comprises: sequentially subjecting a 1,3-propanediol fermentation broth to filtration, sterilization and concentration to obtain a primary concentrated solution; carrying out specific chromatographic separation desalination on the obtained primary concentrated solution by means of using a chromatographic separation system to obtain a desalted solution; concentrating the obtained desalted solution to obtain a secondary concentrated solution, and then purifying the obtained secondary concentrated solution to obtain 1,3-propanediol. By means of the specific chromatographic separation desalination process, the 1,3-propanediol fermentation broth can be directly subjected to chromatographic separation desalination after being subjected to ultrafiltration in the early stage, the nanofiltration membrane filtration procedure is reduced, and the extraction process of 1,3-propanediol is simplified; moreover, the product yield of 1,3-propanediol in the desalination process of the 1,3-propanediol fermentation broth can reach 98% or above, the chromatographic separation desalination rate is increased to 90% or above, the residual amount in a distillation kettle is significantly reduced, the product yield of 1,3-propanediol in a distillation process is improved, and the product quality is significantly improved.
Inventors:
LUO JI'AN (CN)
LIU BIN (CN)
ZHANG YEXING (CN)
SHI GUOZHU (CN)
ZHANG YUN (CN)
ZHU XIAOFEI (CN)
WU WENXUE (CN)
LIU BIN (CN)
ZHANG YEXING (CN)
SHI GUOZHU (CN)
ZHANG YUN (CN)
ZHU XIAOFEI (CN)
WU WENXUE (CN)
Application Number:
PCT/CN2022/096617
Publication Date:
June 22, 2023
Filing Date:
June 01, 2022
Export Citation:
Assignee:
SUZHOU SUZHEN BIOENGINEERING CO LTD (CN)
International Classes:
C07C29/80; C07C29/76; C07C31/20
Foreign References:
| CN114276217A | 2022-04-05 | |||
| CN108117481A | 2018-06-05 | |||
| CN101117306A | 2008-02-06 | |||
| CN106748648A | 2017-05-31 | |||
| US20020133049A1 | 2002-09-19 | |||
| US6428992B1 | 2002-08-06 |
Attorney, Agent or Firm:
SUZHOU CREATOR PATENT & TRADEMARK AGENCY, LTD. (CN)
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