Title:
METHOD OF DESIGNING AGONISTS AND ANTAGONISTS TO IGF RECEPTOR
Document Type and Number:
WIPO Patent Application WO1999028347
Kind Code:
A8
Abstract:
The present invention relates to a method of designing compounds able to bind to a molecule of the insulin receptor family and to modulate the activity mediated by the receptor based on the 3-D structure coordinates of a IGF-1 receptor crystal of Figure 1.
Inventors:
TULLOCH PETER ARCHIBALD DI
BENTLEY JOHN DAVID (AU)
COSGROVE LEAH JANE (AU)
FRENKEL MAURICE JOHN (AU)
GARRETT THOMAS PETER JOHN (AU)
LAWRENCE LYNNE JEAN (AU)
LOU MEIZHEN (AU)
LOVRECZ GEORGE OSCAR (AU)
MCKERN NEIL MORETON (AU)
WARD COLIN WESLEY (AU)
BENTLEY JOHN DAVID (AU)
COSGROVE LEAH JANE (AU)
FRENKEL MAURICE JOHN (AU)
GARRETT THOMAS PETER JOHN (AU)
LAWRENCE LYNNE JEAN (AU)
LOU MEIZHEN (AU)
LOVRECZ GEORGE OSCAR (AU)
MCKERN NEIL MORETON (AU)
WARD COLIN WESLEY (AU)
Application Number:
PCT/AU1998/000998
Publication Date:
September 02, 1999
Filing Date:
November 27, 1998
Export Citation:
Assignee:
COMMW SCIENT IND RES ORG (AU)
TULLOCH PAUL ALEXANDER LM (AU)
BENTLEY JOHN DAVID (AU)
COSGROVE LEAH JANE (AU)
FRENKEL MAURICE JOHN (AU)
GARRETT THOMAS PETER JOHN (AU)
LAWRENCE LYNNE JEAN (AU)
LOU MEIZHEN (AU)
LOVRECZ GEORGE OSCAR (AU)
MCKERN NEIL MORETON (AU)
WARD COLIN WESLEY (AU)
TULLOCH PAUL ALEXANDER LM (AU)
BENTLEY JOHN DAVID (AU)
COSGROVE LEAH JANE (AU)
FRENKEL MAURICE JOHN (AU)
GARRETT THOMAS PETER JOHN (AU)
LAWRENCE LYNNE JEAN (AU)
LOU MEIZHEN (AU)
LOVRECZ GEORGE OSCAR (AU)
MCKERN NEIL MORETON (AU)
WARD COLIN WESLEY (AU)
International Classes:
C07B61/00; C07K14/65; C07K14/705; C07K14/71; G01N33/15; G01N33/50; G01N33/566; G06F17/50; G06F19/00; (IPC1-7): C07K14/705; C07K14/71; G06F17/50; G06F19/00; G06F159/00
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