Title:
METHOD FOR DESIGNING DNA-BINDING PROTEINS OF THE ZINC-FINGER CLASS
Document Type and Number:
WIPO Patent Application WO1999042474
Kind Code:
A3
Abstract:
The invention is directed to the design of DNA-binding proteins (DBP's) with capabilities of binding to any predetermined target double-stranded DNA sequence. Disclosed are the rules for design of the proteins; an algorithm for screening for the optimal DBP's; a computer system employing the rules and the algorithm; general formulae encompassing the proteins; and methods of use of the proteins.
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Inventors:
MICHAELS GEORGE S
MIKELSAAR RAIK-HIIO
FELDMANN RICHARD J
MIKELSAAR RAIK-HIIO
FELDMANN RICHARD J
Application Number:
PCT/US1999/003692
Publication Date:
October 21, 1999
Filing Date:
February 19, 1999
Export Citation:
Assignee:
GENOME DYNAMICS INC (US)
International Classes:
C07B61/00; C07K1/00; C07K14/00; C07K14/47; C12N15/09; G06F17/50; (IPC1-7): C07K1/00; C07K14/47; G06F17/50; C07K14/00
Domestic Patent References:
| WO1996032475A2 | 1996-10-17 | |||
| WO1990007862A2 | 1990-07-26 |
Other References:
BERG E.A.: "Proposed dtructure for the zinc-binding domains from transcripton factor IIIA and related proteins", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 85, January 1988 (1988-01-01), WASHINGTON US, pages 99 - 102, XP002112926
KLEVIT E.A.: "Recognition of DNA by Cys2,His2 zinc fingers", SCIENCE, vol. 253, 1991, LANCASTER, PA US, pages 1367,1393, XP002112927
POMERANTZ E.A.: "STRUCTURE-BASED DESIGN OF A DIMERIC ZINC FINGER PROTEIN", BIOCHEMISTRY, vol. 37, no. 4, 27 January 1998 (1998-01-27), EASTON, PA US, pages 965 - 970, XP002112928
GOGOS E.A.: "Sequence discrimination by alteratively spliced isoforms of a DNA binding zinc finger domain", SCIENCE, vol. 257, 25 September 1992 (1992-09-25), LANCASTER, PA US, pages 1951 - 1955, XP002112929
KLEVIT E.A.: "Recognition of DNA by Cys2,His2 zinc fingers", SCIENCE, vol. 253, 1991, LANCASTER, PA US, pages 1367,1393, XP002112927
POMERANTZ E.A.: "STRUCTURE-BASED DESIGN OF A DIMERIC ZINC FINGER PROTEIN", BIOCHEMISTRY, vol. 37, no. 4, 27 January 1998 (1998-01-27), EASTON, PA US, pages 965 - 970, XP002112928
GOGOS E.A.: "Sequence discrimination by alteratively spliced isoforms of a DNA binding zinc finger domain", SCIENCE, vol. 257, 25 September 1992 (1992-09-25), LANCASTER, PA US, pages 1951 - 1955, XP002112929
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