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Title:
METHOD FOR DETECTING HEPATITIS B VIRUS T216C MUTATION BASED ON MICRO-DROPLET DIGITAL PCR TECHNOLOGY
Document Type and Number:
WIPO Patent Application WO/2022/068079
Kind Code:
A1
Abstract:
A method for detecting Hepatitis B virus (HBV) T216C mutation based on micro-droplet digital PCR technology. By combining micro-droplet digital PCR technology with an amplification mutation system method, i.e., making use of the advantages of high sensitivity and absolute quantification of a digital PCR in combination with the advantage of high specificity of an amplification refractory mutation system, a method capable of detecting a low-abundance HBV mutation situation early is developed, so as to better satisfy the requirements of clinical medication and scientific research.

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Inventors:
REN YANLI (CN)
CHEN ZHI (CN)
ZHU HAIHONG (CN)
HONG MENG (CN)
WU GUODI (CN)
Application Number:
PCT/CN2020/136277
Publication Date:
April 07, 2022
Filing Date:
December 14, 2020
Export Citation:
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Assignee:
UNIV ZHEJIANG (CN)
International Classes:
C12Q1/70; C12N15/11; C12Q1/6858; C12R1/93
Domestic Patent References:
WO2016146064A12016-09-22
WO2018023094A12018-02-01
WO2020033916A12020-02-13
Foreign References:
CN112280896A2021-01-29
CN110863054A2020-03-06
CN107604096A2018-01-19
CN110684862A2020-01-14
CN106381345A2017-02-08
Attorney, Agent or Firm:
HANGZHOU ZHONGCHENG PATENT AGENCY CO., LTD. (CN)
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