Title:
A METHOD FOR DETECTING LYSOSOMAL STORAGE DISEASES
Document Type and Number:
WIPO Patent Application WO2003092601
Kind Code:
A3
Abstract:
A method for detecting lysosomal storage diseases including the steps of performing an assay for a single species of glycosaminoglycan contained in a specimen and correlating results of the assay with lysosomal storage diseases. A body fluid such as urine or blood can be employed as a specimen. The assay can be performed by use of a polypeptide that is capable of specifically binding to a glycosaminoglycan-containing molecule. The polypeptide may be an antibody, or a polypeptide having an antigen-binding site of an antibody.
Inventors:
OKAMURA KAZUO (JP)
MIYAURA SHUICHI (JP)
TOMATSU SHUNJI (US)
MIYAURA SHUICHI (JP)
TOMATSU SHUNJI (US)
Application Number:
PCT/US2003/013517
Publication Date:
September 02, 2004
Filing Date:
April 30, 2003
Export Citation:
Assignee:
SEIKAGAKU KOGYO CO LTD (JP)
UNIV SAINT LOUIS (US)
OKAMURA KAZUO (JP)
MIYAURA SHUICHI (JP)
TOMATSU SHUNJI (US)
UNIV SAINT LOUIS (US)
OKAMURA KAZUO (JP)
MIYAURA SHUICHI (JP)
TOMATSU SHUNJI (US)
International Classes:
G01N33/53; G01N33/66; G01N33/68; (IPC1-7): G01N33/53; G01N33/543
Foreign References:
| US5310646A | 1994-05-10 | |||
| JPH10153600A | 1998-06-09 |
Other References:
TANAKA ET AL: "Detection of urinary keratan sulfate with the use of monoclonal antibody", KETSUGO SOSHIKI, vol. 19, no. 3-4, 1987, pages 236 - 237, XP002978454
THUY ET AL: "A new quantitative assay for glycosaminoglycans", CLINICA CHIMICA ACTA, vol. 212, 1992, pages 17 - 26, XP002978288
THUY ET AL: "A new quantitative assay for glycosaminoglycans", CLINICA CHIMICA ACTA, vol. 212, 1992, pages 17 - 26, XP002978288
Download PDF: