Title:
METHOD FOR DETECTING NEUROLOGICAL DISEASE ASSOCIATED WITH COGNITIVE DYSFUNCTION BY MEASURING EPHA4 EXTRACELLULAR DOMAIN
Document Type and Number:
WIPO Patent Application WO/2012/147798
Kind Code:
A1
Abstract:
A method for detecting a neurological disease associated with cognitive dysfunction is characterized in that the EphA4 extracellular domain is measured from a biological specimen taken from a subject.
Inventors:
OBARA TAKASHI (JP)
INOUE EIJI (JP)
INOUE EIJI (JP)
Application Number:
PCT/JP2012/061097
Publication Date:
November 01, 2012
Filing Date:
April 25, 2012
Export Citation:
Assignee:
EISAI R&D MAN CO LTD (JP)
OBARA TAKASHI (JP)
INOUE EIJI (JP)
OBARA TAKASHI (JP)
INOUE EIJI (JP)
International Classes:
G01N33/53; C12N9/64; C12N15/09
Domestic Patent References:
| WO2008150010A1 | 2008-12-11 | |||
| WO2009069808A1 | 2009-06-04 | |||
| WO2008150010A1 | 2008-12-11 | |||
| WO2009069808A1 | 2009-06-04 |
Other References:
INOUE EIJI ET AL.: "Synaptic activity prompts y-secretase-mediated cleavage of EphA4 and dendritic spine formation", J. CELL BIOL., vol. 185, no. 3, 4 May 2009 (2009-05-04), pages 551 - 564, XP055132106
EISAKU ESUMI ET AL.: "Expression of receptor type tyrosine kinase EphA4 in the spinal cord of autopsy and normal cases", SHINKEI HENSEI SHIKKAN NI KANSURU KENKYUHAN 2000 NENDO KENKYU HOKOKUSHO, 2001, pages 48 - 50, XP008171385
AOKI M. ET AL.: "EphA Receptors Direct the Differentiation of Mammalian Neural Precursor Cells through a Mitogen-activated Protein Kinase-dependent Pathway", J. BIOL. CHEM., vol. 279, no. 31, 30 July 2004 (2004-07-30), pages 32643 - 32650, XP055132110
EIJI INOUE ET AL.: "Alzheimer's Disease (AD) No ni Okeru EphA4/gamma-secretase Signal no Henka", DEMENT. JPN., vol. 25, no. 3, 15 November 2011 (2011-11-15), pages 339, XP008171389
MURAI KK; NGUYEN LN; IRIE F; YAMAGUCHI Y; PASQUALE EB: "Control of hippocampal dendritic spine morphology through ephrin- A3/EphA4 signaling", NAT NEUROSCI., vol. 6, no. 2, February 2003 (2003-02-01), pages 153 - 60, XP009140405, DOI: doi:10.1038/nn994
INOUE E; DEGUCHI-TAWARADA M; TOGAWA A; MATSUI C; ARITA K; KATAHIRA-TAYAMA S; SATO T; YAMAUCHI E; ODA Y; TAKAI Y: "Synaptic activity prompts gamma-secretase-mediated cleavage of EphA4 and dendritic spine formation", J CELL BIOL., vol. 185, no. 3, 4 May 2009 (2009-05-04), pages 551 - 64, XP055112350
MURAI KK ET AL., NAT NEUROSCI., vol. 6, no. 2, February 2003 (2003-02-01), pages 153 - 60
AOTO, J ET AL., BRAIN RES., November 2006 (2006-11-01)
EISAKU ESUMI ET AL.: "Expression of receptor type tyrosine kinase EphA4 in the spinal cord of autopsy and normal cases", SHINKEI HENSEI SHIKKAN NI KANSURU KENKYUHAN 2000 NENDO KENKYU HOKOKUSHO, 2001, pages 48 - 50, XP008171385
AOKI M. ET AL.: "EphA Receptors Direct the Differentiation of Mammalian Neural Precursor Cells through a Mitogen-activated Protein Kinase-dependent Pathway", J. BIOL. CHEM., vol. 279, no. 31, 30 July 2004 (2004-07-30), pages 32643 - 32650, XP055132110
EIJI INOUE ET AL.: "Alzheimer's Disease (AD) No ni Okeru EphA4/gamma-secretase Signal no Henka", DEMENT. JPN., vol. 25, no. 3, 15 November 2011 (2011-11-15), pages 339, XP008171389
MURAI KK; NGUYEN LN; IRIE F; YAMAGUCHI Y; PASQUALE EB: "Control of hippocampal dendritic spine morphology through ephrin- A3/EphA4 signaling", NAT NEUROSCI., vol. 6, no. 2, February 2003 (2003-02-01), pages 153 - 60, XP009140405, DOI: doi:10.1038/nn994
INOUE E; DEGUCHI-TAWARADA M; TOGAWA A; MATSUI C; ARITA K; KATAHIRA-TAYAMA S; SATO T; YAMAUCHI E; ODA Y; TAKAI Y: "Synaptic activity prompts gamma-secretase-mediated cleavage of EphA4 and dendritic spine formation", J CELL BIOL., vol. 185, no. 3, 4 May 2009 (2009-05-04), pages 551 - 64, XP055112350
MURAI KK ET AL., NAT NEUROSCI., vol. 6, no. 2, February 2003 (2003-02-01), pages 153 - 60
AOTO, J ET AL., BRAIN RES., November 2006 (2006-11-01)
Attorney, Agent or Firm:
KOBAYASHI Hiroshi et al. (JP)
Kobayashi 浩 (JP)
Kobayashi 浩 (JP)
Download PDF:
Claims:
Previous Patent: AUTOMATIC WINDING DEVICE FOR FILAMENTOUS MATERIAL AND AUTOMATIC WINDING METHOD
Next Patent: ELECTRONIC DEVICE
Next Patent: ELECTRONIC DEVICE