Title:
METHOD FOR DETECTING NTRK3 FUSANT
Document Type and Number:
WIPO Patent Application WO/2015/012397
Kind Code:
A1
Abstract:
Provided are a method for elucidating a polynucleotide, which is a novel responsible gene of cancer, and detecting said polynucleotide or polypeptide coded thereby on the basis of the finding, a kit and primer set for the detection, a method for screening an inhibitor of the polypeptide, and a pharmaceutical composition for cancer treatment containing the inhibitor. This detection method detects a NTRK 3 fusion protein or a fusion gene for encoding said fusion protein, and a ETV6 fusion protein or a fusion gene for encoding said fusion protein, in a sample originating in a digestive organ from a subject.
Inventors:
TAKEUCHI KENGO (JP)
TOGASHI YUKI (JP)
SAKATA SEIJI (JP)
BABA SATOKO (JP)
TOGASHI YUKI (JP)
SAKATA SEIJI (JP)
BABA SATOKO (JP)
Application Number:
PCT/JP2014/069737
Publication Date:
January 29, 2015
Filing Date:
July 25, 2014
Export Citation:
Assignee:
JAPAN FOUND CANCER (JP)
International Classes:
C12Q1/68; G01N33/15; G01N33/50; G01N33/53; G01N33/68; C12N15/09
Other References:
LACO J. ET AL.: "Mammary analog secretory carcinoma of salivary glands: a report of 2 cases with expression of basal/myoepithelial markers (calponin, CD 10 and p63 protein).", PATHOL RES PRACT., vol. 209, no. 3, March 2013 (2013-03-01), pages 167 - 172, XP028995155, DOI: doi:10.1016/j.prp.2012.12.005
KRATOCHVIL FJ.: "3rd, Mammary analog secretory carcinoma of salivary glands: a report of 2 cases in the lips.", ORAL SURG ORAL MED ORAL PATHOL ORAL RADIOL., vol. 114, no. 5, 2012, pages 630 - 635
SEIJI SAKATA ET AL.: "Bunshi Saibo Seibutsugaku Koza [Fusion Gene in Epithelial Tumors", THE CELL, vol. 45, no. 2, February 2013 (2013-02-01), pages 101 - 103
WAI DH. ET AL.: "The ETV6-NTRK3 gene fusion encodes a chimeric protein tyrosine kinase that transforms NIH3T3 cells.", ONCOGENE, vol. 19, no. 7, 2000, pages 906 - 915
LANNON CL. ET AL.: "ETV6-NTRK3: a chimeric protein tyrosine kinase with transformation activity in multiple cell lineages.", SEMIN CANCER BIOL., vol. 15, no. 3, 2005, pages 215 - 223
YOSHIAKI KINOSHITA ET AL.: "Chimera Idenshi Kaiseki ga Kakutei Shindan ni Yuko de atta Nanbu Shuyo no 2 Rei", PEDIATRIC ONCOLOGY, vol. 40, no. 3, 2003, pages 407
HAJIME ISHIKAWA ET AL.: "Seibutsugaku Jiten, 1st ed.", KABUSHIKI KAISHA, 2010, TOKYO, pages 619
DATABASE GENBANK 20 April 2000 (2000-04-20), "Homo sapiens ETS related protein-growth factor receptor tyrosine kinase fusion proteins (ETV6-NTRK3 fusion) mRNA, partial cds", accession no. F041811
LAMBALLE F. ET AL.: "The trk family of oncogenes and neurotrophin receptors.", PRINCESS TAKAMATSU SYMP., vol. 22, 1991, pages 153 - 170
HATTA Y. ET AL.: "Ovarian cancer has frequent loss of heterozygosity at chromosome 12p12.3- 13.1 (region of TEL and Kipl loci) and chromosome 12q23-ter: evidence for two new tumour-suppressor genes.", BR J CANCER., vol. 75, no. 9, 1997, pages 1256 - 1262
KRATOCHVIL FJ.: "3rd, Mammary analog secretory carcinoma of salivary glands: a report of 2 cases in the lips.", ORAL SURG ORAL MED ORAL PATHOL ORAL RADIOL., vol. 114, no. 5, 2012, pages 630 - 635
SEIJI SAKATA ET AL.: "Bunshi Saibo Seibutsugaku Koza [Fusion Gene in Epithelial Tumors", THE CELL, vol. 45, no. 2, February 2013 (2013-02-01), pages 101 - 103
WAI DH. ET AL.: "The ETV6-NTRK3 gene fusion encodes a chimeric protein tyrosine kinase that transforms NIH3T3 cells.", ONCOGENE, vol. 19, no. 7, 2000, pages 906 - 915
LANNON CL. ET AL.: "ETV6-NTRK3: a chimeric protein tyrosine kinase with transformation activity in multiple cell lineages.", SEMIN CANCER BIOL., vol. 15, no. 3, 2005, pages 215 - 223
YOSHIAKI KINOSHITA ET AL.: "Chimera Idenshi Kaiseki ga Kakutei Shindan ni Yuko de atta Nanbu Shuyo no 2 Rei", PEDIATRIC ONCOLOGY, vol. 40, no. 3, 2003, pages 407
HAJIME ISHIKAWA ET AL.: "Seibutsugaku Jiten, 1st ed.", KABUSHIKI KAISHA, 2010, TOKYO, pages 619
DATABASE GENBANK 20 April 2000 (2000-04-20), "Homo sapiens ETS related protein-growth factor receptor tyrosine kinase fusion proteins (ETV6-NTRK3 fusion) mRNA, partial cds", accession no. F041811
LAMBALLE F. ET AL.: "The trk family of oncogenes and neurotrophin receptors.", PRINCESS TAKAMATSU SYMP., vol. 22, 1991, pages 153 - 170
HATTA Y. ET AL.: "Ovarian cancer has frequent loss of heterozygosity at chromosome 12p12.3- 13.1 (region of TEL and Kipl loci) and chromosome 12q23-ter: evidence for two new tumour-suppressor genes.", BR J CANCER., vol. 75, no. 9, 1997, pages 1256 - 1262
Attorney, Agent or Firm:
MORITA Kenichi et al. (JP)
Ken-ichi Morita (JP)
Ken-ichi Morita (JP)
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